Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

Peter Thiel, Larry Page, Sergey Brin, Bill Maris, Mark Zuckerberg…investment in biotech by leading figures in the world of technology is reaching new heights, with the regenerative medicine market projected to reach $20 billion by 2025 and the overall anti-aging market $345.8 billion by 2018.

These forecasts combined with a recent biotech boom mean that the economic reasons for investing are becoming clear and rising demand is virtually inevitable as the proportion of older individuals continues to grow to unparalleled levels. Bill Gates may have labelled anti-aging efforts as ‘egocentric’, but the investment doesn’t appear to be due to economic reasons alone; there is also a strong humanitarian and aspirational aspect that links some of these individuals together — the desire to utilise technology to create a better society.

‘With all being from a scientific background, Page, Brin and Maris particularly are clear in their belief that science holds the key to radically improving both the human condition and the world we live in — the pinnacle of this being radically prolonging human lifespan. In a recent Bloomberg interview Maris points out we live in an era where science can make all the tools available for any audacious vision out there…To these tech billionaires, evolution is meant to be transcended, and the resources put into organ regeneration, drugs that control ageing, or reprogramming DNA reflects their conviction that people have the right to lead better lives.’

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Misfolding proteins and aggregates are a serious problem for a cell; a great range of research has been able to link poor protein ‘quality control’ with a whole range of diseases, perhaps most famously Alzheimer’s disease. Recent work also suggests that the ‘heat shock’ response, a mechanism that protects against misfolding and corrects badly made proteins, may also become impaired with aging. This gradual deterioration could turn out to be one of the most significant drivers of both aging and age-related disease.

In research that support this theory, a recent paper provides evidence that the endoplasmic reticulum (ER), a cellular compartment which is responsible for creating and correctly forming protein structures, loses its oxidative power with age. This means that it loses the ability to form a type of bond called a disulphide bridge, a strong chemical bond which normally stabilises protein structures and holds them in particular shapes. The chemical environment within the ER was shown to change with age, disrupting the delicate equilibrium in the cell and leading to increased oxidative damage in other areas. Proteins moving through the ER on a production line often require disulphide linkages to mature correctly and stabilise their structure, but without this step they’re unable to do so and remain unstable.

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The brain’s glymphatic pathway clears harmful wastes, especially during sleep. This lateral position could prove to be the best position for the brain-waste clearance process (credit: Stony Brook University)

Sleeping in the lateral, or side position, as compared to sleeping on one’s back or stomach, may more effectively remove brain waste, and could reduce the chances of developing Alzheimer’s, Parkinson’s and other neurological diseases, according to researchers at Stony Brook University.

Stony Brook University researchers discovered this in experiments with rodents by using dynamic contrast magnetic resonance imaging (MRI) to image the brain’s glymphatic pathway, a complex system that clears wastes and other harmful chemical solutes from the brain. They also used kinetic modeling to quantify the CSF-ISF exchange rates in anesthetized rodents’ brains in lateral, prone, and supine positions.

Colleagues at the University of Rochester used fluorescence microscopy and radioactive tracers to validate the MRI data and to assess the influence of body posture on the clearance of amyloid from the brains.

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Massachusetts General Hospital investigators have induced subcutaneous fat cells in a piece of skin from a pig to emit laser light in response to energy delivered through an optical fiber (credit: Matjaž Humar and Seok Hyun Yun/Nature Photonics)

Imagine being able to label a trillion cells in the body to detect what’s going on in each individual cell.

That’s the eventual goal of a Massachusetts General Hospital (MGH) study to allow individual cells to produce laser light. The wavelengths of light emitted by these intracellular microlasers differ based on factors such as the size, shape, and composition of each microlaser, allowing precise labeling of individual cells.

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“I am prepared to meet my Maker. Whether my Maker is prepared for the great ordeal of meeting me is another matter.” — Winston Churchill

Death still enjoys a steady paycheck, but being the Grim Reaper isn’t the cushy job that it used to be.

Call it an abundance of caution. A Microsoft research project has upgraded the encryption protocol that secures the Web to resist attacks from quantum computers—machines that are expected to have stupendous power but have never been built.

Governments and computing giants like IBM, Microsoft, and Google are working on quantum computers because tapping subtle effects of quantum physics should let them solve in seconds some problems that a conventional machine couldn’t solve in billions of years (see “Microsoft’s Quantum Mechanics”). That might allow breakthroughs in areas such as medicine or energy. But such machines would also be able to easily break the encryption used to secure information online.

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WISH COME TRUE: 8-year-old Zion receives the world’s first pediatric double hand transplant at Children’s Hospital of Philadelphia. http://nbcnews.to/1SLmf5m.

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Synthetic biology programming microorganisms to perform some new functions. Genes are made out of DNA; synthetic biology involves inserting synthetic genes that might not have existed before into yeast and reprogramming them to make a new chemistry or things not made naturally by biology. Each gene codes for an enzyme. One can program a new set of enzymes and convert them to intermediate products. If you go through five or even 15 steps, you can get a final product – a polymer, a new drug – creating a chemical factory inside a cell. This is much better than nanotechnology, because in synthetic biology, we get down to molecular size…

Prof. Joseph Jacobson, a leading physicist at the Massachusetts Institute of Technology, is not only the inventor of e-ink but also a mover in creating artificial DNA to eventually cure diseases.

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Professor Hyun-Gyu Park of the Department of Chemical and Biomolecular Engineering at Korea Advanced Institute of Science and Technology (KAIST) has developed a technique to analyze various target DNAs using an aptamer, a DNA fragment that can recognize and bind to a specific protein or enzyme. This technique will allow the development of affordable genetic diagnosis for new bacteria or virus, such as Middle Ease Respiratory Syndrome (MERS). The research findings were published in the June issue of Chemical Communications, issued by the Royal Society of Chemistry in the United Kingdom. The paper was selected as a lead article of the journal.

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