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Improving Quality Of Life & Health, For Hundreds Of Millions Globally, Suffering Food Allergies & Intolerances — Lisa Gable, Chief Executive Officer, Food Allergy Research & Education (FARE)


Lisa Gable is the Chief Executive Officer, of Food Allergy Research & Education (FARE — https://www.foodallergy.org), an organization with a mission to improve the quality of life and the health of 85 million Americans with food allergies and food intolerances, including 32 million of those are at risk for life-threatening anaphylaxis, and to provide them hope through the promise of new treatments. To date FARE has turned over $100 million in donor gifts into ground-breaking research and has provided a voice for the community, advocating on its behalf and offering hope for a better tomorrow.

Ms. Gable has served four U.S. presidents and two governors, counseled Fortune 500 CEOs, and represented global public-private partnerships and non-profits with an end goal of moving organizations to higher levels of performance.

As the former President of the Healthy Weight Commitment Foundation, Ms. Gable created and led a coalition of food and beverage industry corporations and public health and government agencies, resulting in the reduction of 6.4 trillion calories from the American diet.

Ms Gable was appointed the first female U.S. Commissioner General to the 2005 Aichi World EXPO, holding the personal rank of Ambassador, served as a U.S. Delegate to the United Nations Commission on the Status of Women, and served both in the Reagan White House and Defense Department, serving as an advisor to the Secretary of Defense and the Joint Chief of Staff.

Ms. Gable’s corporate experience included serving as senior vice president of Global Public Policy at PepsiCo, and 15 years in Silicon Valley, including Global Brand Identity Manager for Intel Corporation, as Intel was on the cusp of launching what would become one of the most dominant tech brands, Intel Inside.

Among her varied volunteer activities, Ms. Gable has served on several boards including as a National Trustee for the Boys and Girls Club of America, a board member for Girl Scouts of the USA and as a member of the Institute of Medicine Roundtable on Obesity Solutions. A published writer, her new book Turnaround: How to Change Course When Things Are Going South (https://turnaroundbook.com/) will be coming out October 5, 2021.

Ms. Gable also has had recurring media appearances including four years as a regularly scheduled guest with Lifetime’s national morning program The Balancing Act.

I believe since the weird localization of the virus in Japan that this sorta self evolving virus needs to have a counter like a self evolving vaccine but at the very least new variants can be made super fast with new technology in vaccine making.


Washington — Dr. Scott Gottlieb, former Food and Drug Administration commissioner, said Sunday he thinks the U.S. is further into the COVID-19 epidemic driven by the Delta variant than Centers for Disease Control and Prevention (CDC) models are picking up. He said that could mean “hopefully we’re going to turn a corner” in the next two to three weeks.

“We’re not doing a lot of testing. More of the testing that we are doing is antigen tests that are being done at home and not getting reported,” Gottlieb said. “So, I think we’re much further into this epidemic than we’re picking up and hopefully further through this epidemic.”

Getting blood to a wounded soldier could be the difference between life and death. A drone swarm is one way to make that happen in battle.


Blood is usually a finite quality on a battlefield. Battles can cause a number of injuries, from the minor to the critical. If a soldier can get the wound closed in time, they can staunch the loss, but keeping the patient alive may require an influx of new blood. As medics work to aid their comrades, they could receive help from an unusual source: delivery drones, bringing literal fresh blood to the battlefield.

A drone swarm capable of delivering blood was part of Autonomous Advance Force 4.0, an exercise by the United Kingdom’s armed forces in which Royal Marines Commandos trained with modern technology for future war. The July exercise took place in Cumbria and Dorset, with a release announced July 17.

The swarm consisted of six medium-heavy lift drones, Malloy Aeronautics TRV-150s. The TRV-150 can carry up to 140 lbs, at a range of up to 43 miles, with a maximum flight time of 36 minutes. Malloy drones got their start back in 2014 as a hoverbike concept, which was then proposed for the US military as a kind of ridden-drone scout. The US Army explored a large version of the drone as a “tactical resupply” vehicle in 2017. In TRV-150 form, the drone is an octocopter, with two rotors on each of four limbs.

A summary of the sequel trial for a cocktail of drugs that originally turned back epigenetic clocks by 2.5 years. I do wonder what effect plasma filtering has on the thymus if any.


In this video we review the TRIIM study and look at the trial document for TRIIM-X, the extension study that Dr. Fahy is now conducting.

Timing — If you are familiar with the TRIIM Study please use the time links below to jump to TRIIM-X
0:12 : TRIIM Paper Review.
7:11 : TRIIM-X Trial Review.
08:59 : TRIIM vs TRIIM-X

Papers referred to in this video.
Reversal of epigenetic aging and immunosenescent trends in humans Sept 2019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826138/

Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial (TRIIM-X)
https://clinicaltrials.gov/ct2/show/NCT04375657

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Original Article from The New England Journal of Medicine — Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria.


Dr. Moses, Mr. Metzger, and Ms. Liu contributed equally to this article.

A data sharing statement provided by the authors is available with the full text of this article at NEJM.org.

We thank the study participant “Bravo-1” for his dedication and commitment; the members of Karunesh Ganguly’s laboratory for help with the clinical study; Mark Chevillet, Emily Mugler, Ruben Sethi, and Stephanie Thacker for support and feedback; Nick Halper and Kian Torab for hardware technical support; Mariann Ward for clinical nursing support; Matthew Leonard, Heather Dawes, and Ilona Garner for feedback on an earlier version of the manuscript; Viv Her for administrative support; Kenneth Probst for illustrating an earlier version of Figure 1; Todd Dubnicoff for video editing; and the participant’s caregivers for logistic support.

Using high-powered imaging, the researchers were able to see, for the first time, that immune cells called microglia were not just removing damaged material after experimental seizures but actually appeared to be healing damaged neurons.


Summary: Microglia do not only remove damaged materials following a seizure, they also appear to heal damaged neurons.

Source: University of Virginia

University of Virginia School of Medicine researchers have discovered a previously unknown repair process in the brain that they hope could be harnessed and enhanced to treat seizure-related brain injuries.

Common seizure-preventing drugs do not work for approximately a third of epilepsy patients, so new and better treatments for such brain injuries are much needed. UVA’s discovery identifies a potential avenue, one inspired by the brain’s natural immune response.

Summary: A novel helmet that generates a noninvasive oscillating magnetic field was able to reduce tumor mass by 31% in a glioblastoma brain cancer patient.

Source: Houston Methodist.

Houston Methodist Neurological Institute researchers from the department of neurosurgery shrunk a deadly glioblastoma tumor by more than a third using a helmet generating a noninvasive oscillating magnetic field that the patient wore on his head while administering the therapy in his own home. The 53-year-old patient died from an unrelated injury about a month into the treatment, but during that short time, 31% of the tumor mass disappeared. The autopsy of his brain confirmed the rapid response to the treatment.

Late last year, a French company called Carmat received approval in Europe for its total artificial heart. It’s exactly what it sounds like: a heart made of synthetic and biological materials intended for implantation into people who need heart transplants. Now, just half a year later, the first US patient has received one of the hearts.

The transplant took place last week in a 39-year-old man at Duke University Hospital in North Carolina. The man didn’t go to the hospital expecting to have a heart transplant, but it ended up saving his life.

After experiencing unexpected heart failure, he was diagnosed with advanced coronary artery disease (when plaque builds up in the blood vessels that carry oxygen-rich blood to heart) and went in for bypass surgery (which implants a healthy blood vessel from another part of the body to redirect blood around a blocked artery).

Good day to you all.

Sirtuins are once again, making headlines. From a longer lifespan, again, through to helping old and dormant hair follicles to grow new hair, and of course a discourse between certain personalities on twitter, they continue to stimulate the interest and promise so much…

So I have decided to follow up my last sirtuins video with this one, Sirtuins revisited.

Here I look at them all from 1 to 7, to see what is being claimed for each one, and then I look at all the ways we can try to bring them all up to optimum so that we can live long, healthy lives, free from the maladies of old age.

I look at lifestyle interventions from exercise, saunas, cold therapies and more, through to diet choices and then finally on to supplements that are available to boost them all further.

So I hope you find it of use and enjoyable, and have a great weekend.


Sirtuins Anti Aging. Revisited.

Following up on my last sirtuins video I have added more information and an extensive list of what each sirtuin does, and what you can do to optimise yourself, and who you should be bothering.

My videos for more detail.
Exercise https://youtu.be/ZMXFBgcuaaI
Sleep https://youtu.be/iByq-KYVt3I
Sauna https://youtu.be/dTwOMjWnzhg.
Cold https://youtu.be/3C8F6gbVXyU
Diet https://youtu.be/ZZ6ZfIulEoY
Fasting https://youtu.be/OnjsALfx9Uc.
Resveratrol https://youtu.be/uKfIShI7tpI
Original Sirtuins https://youtu.be/cNUFesiescc.

Links to all articles I used to make the video.

Restoration of energy homeostasis by SIRT6 extends healthy lifespan https://www.nature.com/articles/s41467-021-23545-7
SIR2 blocks extreme life span extension.
https://www.cell.com/fulltext/S0092-8674(05)00913-X
Resveratrol not direct activator of SIRT1
https://pubmed.ncbi.nlm.nih.gov/20061378/
Dietary Activators of Sirt1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727669/
Sirt 1 Mitochondrial biogenesis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403509/
Activation of thyroid T3 hormone.
https://pubmed.ncbi.nlm.nih.gov/23922917/
Neurodegenerative diseases.
https://pubmed.ncbi.nlm.nih.gov/21902666/
Insulin resistance/diabetes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753457/
Age-associated weight-gain.
https://www.frontiersin.org/articles/10.3389/fendo.2015.00109/full.
Liver function & body homeostasis.
https://pubmed.ncbi.nlm.nih.gov/21638299/
Human embryonic stem cell differentiation.
https://pubmed.ncbi.nlm.nih.gov/21144831/
Sirt 2 Lower mitochondrial activity & fatty acid metabolism.
https://pubmed.ncbi.nlm.nih.gov/22302938/
Sirt 3 Oxidative stress.
https://pubmed.ncbi.nlm.nih.gov/21658599/
Low levels of SIRT3 insulin resistance & fatty liver disease.
https://portlandpress.com/biochemj/article-abstract/433/3/505/45501/Fatty-liver-is-associated-with-reduced-SIRT3?redirectedFrom=fulltext.
Sirt 4 — Tumor-suppressive benefit. Mitochondrial glutamine metabolism and DNA damage.
https://pubmed.ncbi.nlm.nih.gov/23562301/
Reduce insulin secretion.
https://pubmed.ncbi.nlm.nih.gov/20729089/
Sirt 5 Mitochondrial metabolism &ammonia detoxification/removal.
https://www.cell.com/cell/fulltext/S0092-8674(06)01020-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867406010208%3Fshowall%3Dtrue.
Sirt 6 Genome stability & DNA repair. Low levels metabolic problems & age-related health issues.
https://pubmed.ncbi.nlm.nih.gov/20729089/
Sirt 7 rDNA transcription & DNA repair mechanisms.
https://www.cell.com/cell/fulltext/S0092-8674(06)01020-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867406010208%3Fshowall%3Dtrue.
SIRT7 Old/dormant hair follicles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507325/
Sirt1 overexpression calorie restriction.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107309/#R70
Sirt1 moderate overexpression inflammation, liver cancer, diabetes &hepatic steatosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107309/#R71
Sirt6-overexpressing mice hypoxia & high-fat diet.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107309/#R74
SIRT6 highly fatal form of pancreatic cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107309/#R75
Examples of NAD-boosting molecules include NMN, nicotinamide riboside.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107309/#R141
Inhibitors of CD38 such as apigenin142, quercetin142 & GSK
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107309/#R142
Omega 3 Lower inflammation & oxidative stress https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032683/
Niacin energy metabolism https://www.sciencedaily.com/releases/2013/09/130930101836.htm.
Elevate NAD levels in muscle, blood and other tissues.
https://pubmed.ncbi.nlm.nih.gov/32386566/
Olive oil & sirtuins sirt 1
https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30894-9?rss=yes&utm_source=dlvr.it&utm_medium=twitter.
Polyphenols & sirt 6
https://www.nature.com/articles/s41598-018-22388-5
Polyphenols & sirt 1
https://pubmed.ncbi.nlm.nih.gov/16603228/
Lifespan enhancing properties of sirt 2 — 1999
https://pubmed.ncbi.nlm.nih.gov/10521401/
Anti cancer properties.
https://pubmed.ncbi.nlm.nih.gov/20450879/
DNA repair sirt 1 helping to repair the double helix https://pubmed.ncbi.nlm.nih.gov/18835033/
Sirt 1 role in cellular autophagy.
https://www.pnas.org/content/105/9/3374
SIRT1 also supports mitochondrial autophagy, the detoxification of old cells & cellular renewal.
Sirt & exercise.
https://pubmed.ncbi.nlm.nih.gov/19549533/
High-intensity exercise or cold-exposure activates SIRT1
https://www.sciencedirect.com/science/article/pii/S1097276511009440
Sirt & circadian rhythms.
https://science.sciencemag.org/content/342/6158/1243417?related-urls=yes&legid=sci;342/6158/1243417
Saunas increase NAD+ & SIRT1 levels.
https://scholarcommons.usf.edu/etd/4567/
Cold exposure activate sirtuins.
https://www.sciencedirect.com/science/article/pii/S1097276511009440