https://www.youtube.com/watch?v=N6eDDIyS_EA
Longevity sticker shock is holding back progress in rejuvenation biotechnology.
Filmed at BIL 2016 in Los Angeles.
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Category: biotech/medical
http://democracynow.org — A new article in the medical journal The Lancet has concluded much of the Northern Hemisphere will be too hot by 2085 to host the Summer Olympics. Researchers are projecting only eight cities in the hemisphere outside of Western Europe would be cool enough to host the Games. This includes just three cities in North America: Calgary, Vancouver and San Francisco. The list of cities where it could be too hot is staggering: Istanbul, Madrid, Rome, Paris, Budapest, Tokyo, New York, Chicago, Los Angeles—and the list goes on. Extreme high temperatures have already impacted the athletic world. In 2007, high heat forced the cancellation of the Chicago Marathon. At this year’s U.S. Olympic marathon trials in Los Angeles, 30 percent of the runners dropped out of the race due to the heat. For more, we speak with Kirk Smith, lead author of the article and professor of global environmental health at the University of California, Berkeley.
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What would you say if I told you that aging happens not because of accumulation of stresses, but rather because of the intrinsic properties of the gene network of the organism?
Posted in biotech/medical, law, life extension, mathematics | 3 Comments on What would you say if I told you that aging happens not because of accumulation of stresses, but rather because of the intrinsic properties of the gene network of the organism?
I’m guessing you’d be like: :o.
So, here’s the deal. My biohacker friends led by Peter Fedichev and Sergey Filonov in collaboration with my old friend and the longevity record holder Robert Shmookler Reis published a very cool paper. They proposed a way to quantitatively describe the two types of aging – negligible senescence and normal aging. We all know that some animals just don’t care about time passing by. Their mortality doesn’t increase with age. Such negligibly senescent species include the notorious naked mole rat and a bunch of other critters like certain turtles and clams to name a few. So the paper explains what it is exactly that makes these animals age so slowly – it’s the stability of their gene networks.
What does network stability mean then? Well, it’s actually pretty straightforward – if the DNA repair mechanisms are very efficient and the connectivity of the network is low enough, then this network is stable. So, normally aging species, such as ourselves, have unstable networks. This is a major bummer by all means. But! There is a way to overcome this problem, according to the proposed math model.
The model very generally describes what happens with a gene network over time – the majority of the genes are actually working perfectly, but a small number doesn’t. There are repair mechanisms that take care of that. Also, there are mechanisms that take care of defected proteins like heat shock proteins, etc. Put together all of this in an equasion and solve it, and bam! here’s an equasion that gives you the Gompertz law for all species that have normal aging, and a time independent constant for the negligibly senescent ones.
What’s the difference between those two aging regimes? The model suggests it’s the right combination of DNA repair efficiency and the combined efficiency of proteolysis and heat shock response systems, mediating degradation and refolding of misfolded proteins. So, it’s not the accumulation of damages that is responsible for aging, but rather the properties of the gene network itself. The good news is that even we are playing with a terrible hand at first, there is a chance we can still win by changing the features of our network and making it stable. For example, by optimizing misfolded protein response or DNA repair.
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Fraud detection technology is in high demand and growing thanks to areas such as India. However, there is a huge growing demand for synthetic diamonds in their use in technology, medical, synthetic biology as well.
It takes billions of years to produce a natural diamond, but a laboratory can grow one in days and to the untrained eye they look the same. In an attempt to protect its reputation, De Beers has developed technology that can spot the difference. Ivor Bennett reports.
When dealing with diamonds, one can never be too sure. That’s why at De Beers, it’s not just humans checking the gems anymore, but machines too. SOUNDBITE (English) JONATHAN KENDALL, PRESIDENT, INTERNATIONAL INSTITUTE OF DIAMOND GRADING AND RESEARCH, SAYING: “A synthetic is a man-made product. It’s not a gem, it’s not a beautiful product. It’s not about love and affection and emotion. And it’s not unique and it’s not mysterious. And that’s everything that a diamond is.” It takes about 3 billion years to make a natural diamond. but just three weeks for a synthetic one. To the naked eye though, they look the same. So how do you tell the difference? SOUNDBITE (English) IVOR BENNETT, REUTERS REPORTER, SAYING: “It’s all to do with how the stone looks under UV light. A natural diamond for example will appear dark blue in colour with a regular structure. But if i click on the synthetic one, you can see it’s much lighter with these block-like structures, which is down to its irregular growth.
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Nice.
Engineers at the University of Washington (UW) have devised a new method of wireless communication that converts Bluetooth transmission from mobile devices into Wi-Fi signals. Using this “interscatter” communications technology allows medical devices and implants with limited power sources to gain the ability to send data using low-power Wi-Fi signals to smartphones and smartwatches.
The UW team previously described the technique of “backscattering” ambient RF signals — repurposing existing RF signals in the environment — to enable device-to-device communication without the need for onboard power sources. Now, the team builds on that prior research to introduce “interscattering,” the inter-technology, over-the-air conversion of Bluetooth signals to create Wi-Fi transmissions.
The researchers wrote in a paper that novel medical devices, such as smart contact lenses and neural implants, currently have power constraints that limit their ability to generate Wi-Fi, Bluetooth, or ZigBee transmissions to communicate with smartphones, watches, and tablets. To overcome this, the researchers suggest an interscaterring communication system.
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Will Ichor Therapeutics be the first to clinic with a SENS based approach?
As I mentioned last week, earlier this year Fight Aging! invested a modest amount in the Ichor Therapeutics initiative to develop a treatment for macular degeneration, joining a number of other amateur and professional investors in helping to get this venture started. The approach taken here is based on the results of research carried out at the Methuselah Foundation and SENS Research Foundation over much of the past decade, funded by philanthropists and the support of our community of longevity science enthusiasts. This is how we succeed in building the future: medical science in the laboratory leads to medical development in startup companies, each new stage bringing treatments capable of repairing specific forms of age-related molecular damage that much closer to the clinic.
Ichor Therapeutics is one of a growing number of success stories to emerge from the SENS rejuvenation research community. Young scientists, advocates, and donors involved in earlier projects — years ago now — have gone on to build their own ventures, while retaining an interest in stepping up to do something meaningful to help bring an end to aging. Back in 2010, Kelsey Moody worked on the LysoSENS project to find ways to break down damaging metabolic waste in old tissues; fast-forward six years, and he is the now the CEO of a successful small biotechnology company with a great team, taking that very same technology and putting it to good use. I recently had the chance to ask Kelsey a few questions about the future of SENS rejuvenation research, as well as how the Ichor scientists intend to construct a new class of therapy for macular degeneration, one based on removing one of the root causes of the condition.
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