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This is actually pretty significant to see from DARPA; however, not a total shock given the importance of Synthetic Biology and various parties in the military understanding how CRISPR can be used as a weapon.


A new DARPA program could help unlock the potential of advanced gene editing technologies by developing a set of tools to address potential risks of this rapidly advancing field. The Safe Genes program envisions addressing key safety gaps by using those tools to restrict or reverse the propagation of engineered genetic constructs.

“Gene editing holds incredible promise to advance the biological sciences, but right now responsible actors are constrained by the number of unknowns and a lack of controls,” said Renee Wegrzyn, DARPA program manager. “DARPA wants to develop controls for gene editing and derivative technologies to support responsible research and defend against irresponsible actors who might intentionally or accidentally release modified organisms.”

Safe Genes was inspired in part by recent advances in the field of “gene drives,” which can alter the genetic character of a population of organisms by ensuring that certain edited genetic traits are passed down to almost every individual in subsequent generations. Scientists have studied self-perpetuating gene drives for decades, but the 2012 development of the genetic tool CRISPR-Cas9, which facilitates extremely precise genetic edits, radically increased the potential value of—and in some quarters the demand for—experimental gene drives.

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DARPA’s Safe Genes program aims to build a biosafety and biosecurity toolkit to reduce potential risks and encourage innovation in the field of genome editing

The Safe Genes program could help unlock the potential of advanced gene editing technologies by developing a set of tools to address potential risks of this rapidly advancing field. The Safe Genes program envisions addressing key safety gaps by using those tools to restrict or reverse the propagation of engineered genetic constructs.

“Gene editing holds incredible promise to advance the biological sciences, but right now responsible actors are constrained by the number of unknowns and a lack of controls,” said Renee Wegrzyn, DARPA program manager. “DARPA wants to develop controls for gene editing and derivative technologies to support responsible research and defend against irresponsible actors who might intentionally or accidentally release modified organisms.”

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https://youtube.com/watch?v=8mDoH-06ayA

By Alice Klein

Making a splash? Engineers have created metallic nanofish that are inspired by the swimming style of real fish, and could be used to carry drugs to specific sites of the body.

The nanofish are 100 times smaller than grains of sand, and are constructed from gold and nickel segments linked by silver hinges. The two outer gold segments act as the head and tail fin, while the two inner nickel segments form the body. Each segment is around 800 nanometres long, a nanometre being one billionth of a metre.

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We are entering an era of directed design in which we will expand the limited notion that biology is only the ‘study of life and living things’ and see biology as the ultimate distributed, manufacturing platform (as Stanford bioengineer, Drew Endy, often says). This new mode of manufacturing will offer us unrivaled personalization and functionality.

New foods. New fuels. New materials. New drugs.

We’re already taking our first steps in this direction. Joule Unlimited has engineered bacteria to convert CO2 into fuels in a single-step, continuous process. Others are engineering yeast to produce artemisinin — a potent anti-malarial compound used by millions of people globally. Still other microbes are being reprogrammed to produce industrial ingredients, like those used in synthetic rubber.

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New research suggests that nerve cells may be able to repair themselves by mobilizing mitochondria by removing a certain protein in cells. This may help combat neurological diseases such as Alzheimer’s in the near future.

The Mitochondria is the powerhouse of the cell. We all know that. It causes reactions that generate adenosine triphosphate (ATP), a source of chemical energy in a cell. A typical animal cell contains 1000 to 2000 mitochondria. Yet, that’s not all we learned in high school biology. Remember that neurons or nerve cells do not have the ability to repair themselves once damaged? Well, these two facts have stirred quite a bit of interest.

Scientists have found out that nerve cell regeneration is possible. Researchers from National Institute of Neurological Disorders and Stroke in the US restored mitochondrial mobility in a group of mice and observed regeneration of nerve cells.

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