Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

In a World View opinion column published in Nature, a Case Western Reserve University School of Medicine researcher calls for animal-human embryo research to proceed — but only with strong animal protections in place. So-called “chimera” research raises the hope of producing human organs in genetically modified large animals, such as pigs and sheep, offering a potential solution to the persistent shortage of human organs for transplantation.

Insoo Hyun, PhD, associate professor of bioethics, urges such research to proceed only after “knowing the right and wrong ways to treat sentient beings according to complexities of their attributes.”

Hyun’s recommendations appear in the journal’s September 15th issue and come a week after the National Institutes of Health closed a month-long public comment period on proposed new regulations, widely expected to be adopted, that would lift a moratorium that currently forbids federal funding for chimera embryo research.

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Microsoft has vowed to “solve the problem of cancer” within a decade by using ground-breaking computer science to crack the code of diseased cells so they can be reprogrammed back to a healthy state.

In a dramatic change of direction for the technology giant, the company has assembled a “small army” of the world’s best biologists, programmers and engineers who are tackling cancer as if it were a bug in a computer system.

This summer Microsoft opened its first wet laboratory where it will test out the findings of its computer scientists who are creating huge maps of the internal workings of cell networks.

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Clay Wang brought his kids to the California Space Center a few years ago to show them the Space Shuttle. But as he looked up at Endeavour and pondered human space exploration, the pharmacologist wondered, “What if a crew runs out of medicine halfway to Mars?”

A lot of things can go wrong during a three-year mission to Mars, and there’s only so much medicine you can pack. “For food you can predict exactly how much the astronauts will need to eat,” says Wang. “Medicine you can’t predict.”

What if they develop a sudden need for a drug that wasn’t packed? Compounding the problem is the fact that the space environment seems to make many drugs lose potency and degrade more quickly compared to drugs on Earth.

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Scientists at Vanderbilt University have developed a first-ever implantable artificial kidney. The artificial kidney contains a microchip filter and living kidney cells that can function using the patient’s heart, and this bio-synthetic kidney acts like the real organ, removing salt, water and waste products to keep patients with kidney failure from relying on dialysis.

The key to this new development is a breakthrough in the microchip itself, which uses silicon nanotechnology. “[Silicon nanotechnology] uses the same processes that were developed by the microelectronics industry for computers,” said Dr. William H. Fissell IV, who led the team that developed the device.

The microchips are affordable, precise, and function as an ideal filter.

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Researchers have developed machine learning software that can accurately diagnose a patient’s breast cancer risk 30 times faster than doctors, based on mammogram results and personal medical history.

The system could help doctors give better diagnoses the first time around — which means fewer mammogram callbacks and false positives.

“This software intelligently reviews millions of records in a short amount of time, enabling us to determine breast cancer risk more efficiently using a patient’s mammogram,” said one of the researchers, Stephen Wong, from Houston Methodist Research Institute. “This has the potential to decrease unnecessary biopsies.”

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That brought a lot of media attention, and Giorgio got skittish. “They didn’t want to have the perception from customers that their company was developing genetically modified organisms,” says Yang. Yang is still working to perfect the anti-browning in his academic lab, but he has no immediate plans to commercialize it.

The anti-browning trait might also just be a tough sell to customers: When a Canadian apple wanted to sell a GM apple that doesn’t brown—genetically altered through conventional means—it had to battle assumptions that growers just wanted to hide bruised produce. Which is, well, true. Produce that doesn’t brown when handled does also mean less waste for stores and growers.

In Sweden, Jansson is no stranger to unease over genetic engineering. His colleagues recently returned from a conference where activists flung cow dung and eggs at scientists. The CRISPR-edited cabbage he grew he actually got from researchers outside Sweden, who did not want their names or even their country revealed, fearing backlash from environmental activists. Jansson did his cabbage stunt because he wanted people to start thinking about what CRISPR could mean for food.

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This is wild: a team of Israeli scientists developed a contraption that uses a person’s brain waves to remotely control DNA-based nanorobots — while the nanobots were inside a living cockroach. When prompted by a human thought, the clam shell-like robots opened up, revealing a drug-like molecule that tweaked the physiology of the cockroach’s cells.

Though “merely a demonstration and proof of concept,” the technology represents a new era of brain-nanomachine interfaces that links a person’s mental state to bioactive payloads such as drugs. Future techniques that build upon this prototype could be helpful for schizophrenia, depression or other mental disorders, in that the drugs only activate when a patient’s brain waves show signs of abnormality.

Talk about the power of positive thinking!

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