Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

The SENS Research Foundation launched the new Alliance Program in January and important step towards the kind of future we would all like to see.

SRF Director of Alliances David Brindley returned to the stage to introduce our new Alliance Program, launched in January 2016 with an initial $500,000 grant from SRF and building on David’s experience managing the successful CASMI Translational Stem Cell Consortium. Although SENS research to date has produced very promising pre-clinical results, the novelty and disruptiveness of the platform means that many of the therapies we propose currently lack a clear path to the market. The Alliance Program is designed to streamline that process in partnership with existing public and private entities worldwide, particularly by funding PhD and post-doctoral fellowships addressing specific translational needs.

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As atoms in our bodies were made in stars millions of years ago, it’s been common to propose that we are, in fact, made of stars. Now comes news of another mind-blowing cosmic relationship as physicists conclude that human cells and neutron stars share structural similarities, which look like multi-story parking garages.

Neutron stars are quite strange space objects. They come to life as a result of supernova explosions of massive stars and are incredibly dense. While they are the smallest stars, they can pack as much mass as two Suns into a star with the radius of just 10 kilometers.

What the scientists found is that material inside human cell cytoplasms (fluid around a cell nucleus) looks like helices connecting stacks of evenly spaced sheets, dubbed “Terasaki ramps”.

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Biologists at Caltech have developed a new system for visualizing connections between individual cells in fly brains. The finding may ultimately lead to “wiring diagrams” of fly and other animal brains, which would help researchers understand how neurons are connected.

“To understand how the brain works we need to know how neurons are wired to each other,” says Carlos Lois, research professor in the Division of Biology and Biological Engineering at Caltech and principal investigator of the new research, which appears in the November issue of the journal Development. “This is similar to understanding how a computer works by looking at how transistors are connected.”

Animals are made up of different types of specialized cells. In order for an animal to function, the cells have to be able to communicate with each other. For example, neurons directly communicate with so that an animal can move. In diseases such as cancer, this communication process can go awry: when tumors metastasize, they no longer “listen” to neighboring cells that tell them not to grow. Instead, the grow uncontrollably and migrate to other parts of the body.

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Scientists from the University of Basel have succeeded in organizing spherical compartments into clusters mimicking the way natural organelles would create complex structures. They managed to connect the synthetic compartments by creating bridges made of DNA between them. This represents an important step towards the realization of so-called molecular factories. The journal Nano Letters has published their results.

Within a cell there are specialized compartments called organelles, as for example nucleus, mitochondria, peroxisomes and vacuoles that are responsible for specific functions of the cell. Almost all sophisticated biological functions of cells are realized by self-organization, a process by which molecules adopt a defined arrangement based on their specific conformations and properties, without outside guidance.

Using self-organization of nano-objects into complex architectures is a major strategy to produce new materials with improved properties or functionalities in fields such as chemistry, electronics and technology. For example, this strategy has already been applied to create networks of inorganic solid nanoparticles. However, so far, these networks were not able to mimic sophisticated structures that have biological functions within the cells and thus have potential application in medicine or biology.

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2 November 2016. Two companies partnering with Auburn University developed a synthetic virus to find and destroy tumor cells in a type of bone cancer in dogs. Financial and intellectual property aspects of the agreement between synthetic gene company Gen9 in Cambridge, Massachusetts, design systems developer Autodesk Inc. in San Rafael, California, and Auburn University College of Veterinary Medicine in Alabama were not disclosed.

The research team created a synthetic version of canine adenovirus type 2, or CAV2, a virus usually associated with hepatitis in dogs. In this case, the synthetic CAV-2 virus is designed as an oncolytic virus that finds and attacks cancer cells, while leaving healthy cells and tissue intact. The genome in the organism is believed to be the longest in a functional virus synthesized for cancer research, with about 34,000 base pairs of nucleic acids. The human genome, by comparison, has about 3 billion base pairs.

The technology provided by Gen9 in this project makes it possible to eventually produce synthetic therapeutic viruses tailored for specific patients. Gen9 offers customized gene synthesis and is developing a library of synthesized proteins and antibodies. One of the 4 year-old company’s founders is George Church, a geneticist at Harvard Medical School and serial entrepreneur. In August 2016, as reported in Science & Enterprise, Church and colleagues, including those from Gen9, developed a synthetic E. coli bacteria genome with redundant DNA components removed.

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Scientists have been working for decades on engineered viruses that can hunt down and get inside cancer cells, cause them to burst and spur the immune system to mop up whatever malignant cells might be left behind. Only one such treatment has successfully become an FDA-approved cancer treatment.

That one drug, from Amgen, isn’t selling much. But that small victory a year ago has emboldened others to go forward with their own ideas to advance this approach to cancer therapy, known as oncolytic virus therapy.

One of the aspiring players in the oncolytic virus field, Ottawa, Canada-based Turnstone Biologics, is announcing today it has raised $41.4 million in a Series B venture financing. The round was led by OrbiMed Advisors, and included F-Prime Capital Partners and a couple of existing investors, FACIT and Versant Ventures. The new money will add on to the $11.3 million Series A round from a year ago.

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From time to time, the Singularity Hub editorial team unearths a gem from the archives and wants to share it all over again. It’s usually a piece that was popular back then and we think is still relevant now. This is one of those articles. It was originally published October 25th, 2015. We hope you enjoy it!

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Researchers at the University of Houston have reported a new method for inducing superconductivity in non-superconducting materials, demonstrating a concept proposed decades ago but never proven.

The technique can also be used to boost the efficiency of known superconducting materials, suggesting a new way to advance the commercial viability of superconductors, said Paul C.W. Chu, chief scientist at the Texas Center for Superconductivity at UH (TcSUH) and corresponding author of a paper describing the work, published Oct. 31 in the Proceedings of the National Academy of Sciences.

“Superconductivity is used in many things, of which MRI (magnetic resonance imaging) is perhaps the best known,” said Chu, the physicist who holds the TLL Temple Chair of Science at UH. But the technology used in health care, utilities and other fields remains expensive, in part because it requires expensive cooling, which has limited widespread adoption, he said.

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Come “ask me anything” right now!!! I’m trying to answer all questions I get asked:

Hi Reddit,

Thank you for having me here. My name is Zoltan Istvan, and I’m a futurist, journalist, and science fiction writer. I’m also the 2016 Presidential candidate for the Transhumanist Party.

For the last 725 days, I have been campaigning full time to spread transhumanism and life extension policies across America and the world. While I never expected to win the US Presidency, my campaign has received a lot of attention—both good and bad—for its emphasis on radical science, technology, secularism, and futurist ideas.

During my campaign, I’ve spoken on transhumanism at the World Bank, consulted with the US Navy on artificial intelligence, got a chip implanted in my hand, interviewed with underground group Anonymous, and drove a coffin-shaped bus called the Immortality Bus across America to deliver a Transhumanist Bill of Rights to the US Capitol. My 20-point political platform has many futurist policies in it, but some of the most important ones are supporting a Universal Basic Income, classifying aging as a disease, legalizing all drugs, creating a Transhumanist Olympics, and taking money from the military and giving it to science.

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