Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

Cell powerhouses are typically long and lean, but with brain injury such as stroke or trauma, they can quickly become bloated and dysfunctional, say scientists who documented the phenomena in real time for the first time in a living brain.

The scientists also found that without giving these mitochondria anything but time, they often resume their usual healthy shape once blood and oxygen were restored to mild or moderately damaged tissue, said Dr. Sergei Kirov, neuroscientist in the Department of Neurosurgery at the Medical College of Georgia at Augusta University.

“We believe this is good evidence that mitochondria can recover their normal form following brief periods of ischemia from stroke or trauma and that drugs that enhance their recovery may improve overall recovery from these sorts of injuries,” Kirov said.

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Another difference between normal and abnormal cells — cancer cells can continue to grow despite damage to cell structures and changes in the number of chromosomes.

Scientists have uncovered how tumours are able to grow despite significant damage to the structure and number of their chromosomes — the storage units of DNA — according to two new studies published in Cancer Cell and Cancer Discovery today.

“We hope that understanding these mechanisms will allow us to limit drug resistance and improve the efficacy of cancer therapies.” - Professor Charles Swanton

Healthy cells are programmed to self-destruct if there are mistakes in their genes that can’t be fixed, but cancer cells can carry on growing with these abnormalities. Over time, further genetic changes allow them to keep growing, spread, and become resistant to treatment.

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Researchers have identified a drug that can regenerate teeth from the inside out, possibly reducing the need for artificial fillings.

The drug was previously used in Alzheimer’s clinical trials, and it now appears to improve the tooth’s natural ability to heal itself. It works by activating stem cells inside the tooth’s pulp centre, prompting the damaged area to regenerate the hard dentin material that makes up the majority of a tooth.

“The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine,” said lead author Paul Sharpe from King’s College London.

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More data for caloric restriction and health benefits.

The long-term response to calorie restriction has long been of interest to the aging research community, and particularly in the past few decades as the tools of biotechnology allowed for a more detailed analysis of the metabolic changes that accompany a reduced calorie intake. A restricted diet extends healthy life spans in near all species tested to date, though to a much greater extent in short-lived species than in long-lived species such as our own. Considerable effort is presently devoted to the development of drugs that can replicate some fraction of calorie restriction — more effort than is merited in my opinion, given that the optimal result for extension of human life span achieved via calorie restriction mimetics will be both hard to achieve safely and very limited in comparison to the gains possible through rejuvenation therapies after the SENS model. Repairing damage within the existing system should be expected to outdo attempts to change the system in order to slow the accumulation of damage, in both efficiency and size of result.

Not everyone is interested in the long term, however. The short term health benefits of calorie restriction appear quickly and are surprisingly similar in mice and humans, given that calorie restriction in mice results in significantly extended life and calorie restriction in humans does not. The beneficial adjustments to metabolism and organ function are for the most part larger and more reliable than similar gains presently achievable through forms of medicine. That is more a case of medical science having a long way to go yet than calorie restriction being wondrous, however. Still, the short term benefits are coming to the attention to wider audience within the research and medical community.

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Grassroots funding of fundamental science and private enterprize will lead the way in rejuvenation biotechnology not the traditional funding sources from Government which are shrinking every year.

It is important to understand that innovation and progress is unlikely to come from the Government and the traditional grant system which is shrinking every year. Rejuvenation biotechnology will likely be funded with a mix of fundraising for fundamental breakthrough technologies followed by private enterprize taking discoveries to market. This is why supporting science is critcial as relying on the Government to innovate and drive progress is unlikely to yield results anytime soon.

“Today, researchers compete for government grants at increasingly shorter intervals and with diminishing chances of success: Less than 1 in 5 grant applications succeeds. This inhibits risk taking.

By contrast, private investment in medicine has kept pace with the aging population and is the principal engine for advancement. More than 80% of new drug approvals originate from work solely performed in private companies. Note that such drug approvals come on average 16 years after the beginning of clinical trials, which typically cost $2.5 billion from start to finish. Even if grant-subsidized academics wanted to create a new drug, economic reality prevents it.”

#aging #crowdfundthecure

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CRISPR can help us end many diseases and guide evolution and is probably one of the most powerful tools we have recently added to our toolkit.

Imagine you could edit a mouse’s genes to be resistant to Lyme Disease. The mouse would breed and evolution would take its course, leading to the extinction of the disease. That’s the vision for scientists developing CRISPR, technology that allows scientists to rewrite the code of life. William Brangham talks to Michael Specter who wrote about CRISPR for The New Yorker.

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It’s an exciting time to be an elderly mouse. Researchers believe that by removing senescent cells (cells with a persistent damage response), which naturally accumulate with age, senior rodents can regrow hair, run faster, and improve organ function. This strategy may bring us one step closer to the “fountain of youth,” but it’s important to be cautious and not hype, says researcher of aging Peter de Keizer of the Erasmus University Medical Center in the Netherlands. In an Opinion published December 29 in Trends in Molecule Medicine, he discusses the milestones the field still needs to hit before translation in humans is ready for discussion.

#aging #crowdfundthecure

https://www.sciencedaily.com/releases/2016/12/161229141835.htm

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Interesting position.

Anonymous by request.

“The human energy field exists as an array of oscillating energy points that have a layered structure and a definite symmetry and these properties fulfill the definition of a normal crystal in material form” – Marc Vogel.

The human body is a universe onto itself; a vast, intricate system of incredible sensitivity and detail. It has been the subject of wonder, philosophy and scientific study for centuries, yet its most elemental design is still shrouded in mystery. What is the relation of biological life to the Cosmos – to the fabric of space and time itself? Is our body the “earthen machine” of Descartes; an “automaton” of discrete mechanical function? Are we really locked in an endless struggle against the ticking clock of thermodynamic entropy – of increasing disorder – as is the view of contemporary physics? The fractal-holographic model sheds new light on these questions; a unified description of the Cosmos reveals its true relation to Man, a relationship so entangled, so intimate that the two cannot be viewed apart…

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