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Category: biotech/medical

Whilst looking through recent papers about biomarkers and this recent open access paper crossed my desk. The paper is the latest in a line of top to bottom reviews of aging biomarkers for humans. With companies like Unity Biotechnology and the David Sinclair lab entering human clinical trials later this year for senescent cell removal and DNA repair respectively, the development of effective biomarkers to measure how someone is aging and how therapies effect that are a matter of urgency.

Given that there are various causes of aging and that rejuvenation therapies will generally only target one or two of these processes, the first therapies will likely only be partially effective. The aging processes are all interlinked as well so affecting one may effect others, hence there is a need for a comprehensive panel of biomarkers in order for researchers to prove the efficacy of therapies.

Another thing to consider with a therapy such as senescent cell removal is, whilst you can measure how effective it is at removing senescent cells (to a reasonable degree using β-galactosidase etc…) being able to demonstrate the wider benefits of doing so is trickier. So the challenge here is to find a suitable range of biomarkers that can provide a good level of proof that rejuvenation has occurred when using these therapies. This means various measures of functional age and health are required, and these measures should be something the research community as a whole agree upon as being suitable.

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A collaborative team of scientists and physicians from the Oxford University, Cambridge University, Imperial College London, University College London and King’s College London have made a remarkable progress towards curing patients with HIV infection.

Of 50 patients taking part in NHS funded revolutionary clinical trial, a 44-year-old British man is the first to complete the trial. He showed no sign of the virus in his blood following treatment.

HIV, the human immunodeficiency virus, is a retrovirus found in body fluids of infected person. These can be semen, vaginal and anal fluids, blood, and breast milk. It can be easily transmitted through unprotected sex or simply sharing infected needles. An infected mother can also transmit HIV to her child during pregnancy, delivery, or breastfeeding.

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LEAF caught up with Futurist David Wood at the recent International Longevity and Cryopreservation Summit in Madrid to talk about rejuvenation biotechnology.

We recently attended the International Longevity and Cryopreservation Summit in Madrid. LEAF director Elena Milova caught up with futurist David Wood at the summit to ask him about his work and his views on the development of rejuvenation biotechnology.

David is the Chair of the London Futurists a group who organize regular public meetings to discuss the future and how technology and science will change the world we live in. It is their aim to engage and educate the public about science and foster better understanding for what is credible in science and what is not.

He is the author of the recent book “The Abolition of Aging: The forthcoming radical extension of healthy human longevity” a book covering rejuvenation biotechnology published in 2016. The book discusses the various bottlenecks, concerns and technologies relevant to the field of rejuvenation biotechnology in the hope that readers can learn and be more informed about these technologies that could radically change society in the near future. If you are new to the subject we recommend reading this book for an excellent high level view of the field, the progress and the social issues that surround its development.

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https://youtube.com/watch?v=0TMeRdDEuIg

New research suggests that the human brain is almost beyond comprehension because it doesn’t process the world in two dimensions or even three. No, the human brain understands the visual world in up to 11 different dimensions.

The astonishing discovery helps explain why even cutting-edge technologies like functional MRIs have such a hard time explaining what is going on inside our noggins. In a functional MRI, brain activity is monitored and represented as a three-dimensional image that changes over time. However, if the brain is actually working in 11 dimensions, looking at a 3D functional MRI and saying that it explains brain activity would be like looking at the shadow of a head of a pin and saying that it explains the entire universe, plus a multitude of other dimensions.

The team of scientists led by a group from Scientists at the École Polytechnique Fédérale de Lausanne in Switzerland detected the previously unknown complexities of the brain while working on the Blue Brain Project. The project’s goal is to create a biologically accurate recreation of the human brain.

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“Deep Learning” computer systems, based on artificial neural networks that mimic the way the brain learns from an accumulation of examples, have become a hot topic in computer science. In addition to enabling technologies such as face- and voice-recognition software, these systems could scour vast amounts of medical data to find patterns that could be useful diagnostically, or scan chemical formulas for possible new pharmaceuticals.

But the computations these systems must carry out are highly complex and demanding, even for the most powerful computers.

Now, a team of researchers at MIT and elsewhere has developed a new approach to such computations, using light instead of electricity, which they say could vastly improve the speed and efficiency of certain deep learning computations. Their results appear today in the journal Nature Photonics (“Deep learning with coherent nanophotonic circuits”) in a paper by MIT postdoc Yichen Shen, graduate student Nicholas Harris, professors Marin Soljacic and Dirk Englund, and eight others.

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NASA has revealed plans to grow bioprinted cancer cells in space in a bid to advance cancer research.

Utilizing the microgravity environment, NASA hopes to the cell structures will grow in a more natural spherical shape. Since, back on earth in vitro the cells have only able been able to grow in two-dimensional layers. However to harness the cells without the presence of gravity, NASA is hoping to employ magnets.

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The concept of repairing age-related damage to prevent diseases is now mainstream and openly talked about by most acadmics.

Earlier this year the second Scripps Florida Symposium was held and now this open access paper reports on the event. The title of of the event was ‘Advances in Therapeutic Approaches to Extend Healthspan’ and was held on January 22nd–25th, 2017 at The Scripps Research Institute in Jupiter, Florida.

It is once again very refreshing to see that the focus of the researchers here is now firmly on intervening on the various aging processes in order to prevent or treat age-related diseases. Less than a decade ago suggesting addressing the aging processes to treat disease as a preventative form of medicine would have jepordised the chances of funding, or even damaged a researcher’s career prospects. Now the majority of researchers are engaged in exploring the potential of increasing healthspan (the period of life spent free of age-related disease) with the aim of delaying or preventing age-related diseases.

The taboo of talking about doing something about aging

Whilst there is still resistance in academia to talk in public about the potential of these therapies leading to not only healthier but also longer lives, it is nonetheless a step in the right direction. The discussion has changed dramatically in the last decade and the taboo of targeting the aging process has largely been banished, this in our view is a good thing. Only the most conservative scientists cling to the idea that nothing can be done about aging despite the mountains of evidence suggesting otherwise.

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We teamed up the MMTP last week and did a special longevity live panel on Facebook with Dr. Aubrey de Grey, Dr. Alexandra Stolzing, Dr. Oliver Medvedik and guests. Check it out.

We teamed up with the MMTP for their “How to Promote Longevity?” Live Panel. Dr. Aubrey de Grey, Dr. Alexandra Stolzing and Dr. Oliver Medvedik and guests discuss the latest research and progess in rejuvenation biotechnology.

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