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Jim Mellon and Al Chalabi are back with another successful venture into the world of science investment. Following their acclaimed 2012 book “Cracking the code”, whose spotlight was on the life sciences industry, Juvenescence takes us on a compelling journey through the dawning market of longevity and rejuvenation biotechnology, which the authors predict will be the biggest “money fountain” to hit the financial world in the coming years.

Juvenescence is a visionary book, debunking the sometimes questionable past of longevity research and steering us towards a ‘brave new world’ in which advances in medicine are already leading to clinical trials whose aim is to extend human lifespan to unprecedented levels.

Mellon and Chalabi come across as eloquent devotees of cold, hard science, and for a book targeted primarily at investors, biologists and experts will be hard-pressed to find inaccuracies in the many heavily technical sections. The authors explain the science of aging in an engaging and accessible manner, bridging the gap between the lab and the public with ease and tact. They employ elegant metaphors to explain complex processes as well as some light-hearted ones, including the “Deadly Quintet”, which reads more like the title of a long-lost Tarantino film, or the “Actuarial Escape Velocity”, a reference to the controversial “Longevity Escape Velocity” promoted by Aubrey de Grey. Mellon and Chalabi use state-of-the-art research whenever possible, with recent, fresh-from-the-lab studies making up the majority of sources.

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Very recently, the World Health Organization, which is essentially the United Nations’ agency for coordinating international health-related efforts, has launched The Global Online Consultation on Research Priority Setting for Healthy Aging. A corresponding survey is available on the WHO website and can be filled until September 30. As WHO is the main source of policy recommendations for the UN member states, its position can significantly influence the allocation of state funding to different areas of scientific research.

This is why we at LEAF urge you to step in and fill out the WHO survey; our community needs to demand more focused efforts to understand the basic mechanisms of aging, to develop innovative therapies to address these mechanisms, and to remove the barriers delaying the implementation of rejuvenation technologies into clinical practice.

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Summary: Without DNA repair, the damage in our genome builds up, which in turn causes disease and aging. Repairing DNA damage is one of the holy grails of anti-aging medicine. As a review earlier this month shows, scientists have made headway in understanding our DNA repair mechanisms. While researchers haven’t found a way to repair DNA damage, they have found potential ways to mitigate some of its effects.

For those us wanting to live in good health to the age of 120, the damaged DNA in our bodies is keeping us from reaching our goal.

Research has shown that our DNA repair mechanisms decline as we get older. Unless we are lucky to be among the tiny percentage of centenarians who are blessed with superb DNA repair mechanisms, the odds are that unrepaired DNA damage will strike us down with chronic diseases before we reach our goal.

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Only two years ago, when I launched my advocacy website Rejuvenaction, I didn’t think I would read a book like Juvenescence so soon; yet, the topic of rejuvenation biotechnologies has already become mainstream enough to lead investors of the calibre of Jim Mellon and Al Chalabi to devote a whole book to it.

As Juvenescence is a book aimed at potential new investors in rejuvenation biotechnologies, I expected it to be an extremely technical and detailed account of things I don’t understand, such as finance, markets, and funds. To my delight, this was not the case. Rather, the details Juvenescence dives into are primarily those of the emerging field of rejuvenation science (alas, still something whose details I don’t fully understand).

The book explains the paradigm shift that is currently taking place and changing the way science sees aging—no longer as an inevitable fact of life but rather as a disease to be eradicated like any other—and goes through a biology 101 crash course for the benefit of readers who might be not too well versed in the science of life.

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A new mouse study by University of Florida Health researchers shows that multiple sclerosis can be inhibited or even reversed by using a gene therapy that stops the immune response caused by the disease in its tracks.

What is multiple sclerosis?

Multiple sclerosis (MS) is an autoimmune disease, affects around 2.3 million people worldwide and is the most common neurological disease in young adults. The average life expectancy for people with MS is around 6 to 7 years lower than the norm[1]. This lifelong condition begins when the immune system attacks the myelin sheath surrounding nerve.

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Out of necessity, Japan has been pushing on the robotics frontier for years. As a result, the proliferation and embrace of robots goes well beyond the Japanese factory floor to include schools, hospitals, nursing homes, airports, train stations and even temples.


Unfavourable demographics are spurring innovation — and investment opportunities.

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I did a new interview on #transhumanism for some journalism students at Germany’s Technical University of Dortmund. It’s in English:


Mechanical bodyparts are very common nowadays – a lot of humans have a hip replacement or a pacemaker. Technology helps saving our lives rather often. Some people want to take this a lot further – a philosophical and scientific movement called Transhumanism. Zoltan Istvan Gyurko is one of the most famous Transhumanists, he even ran for president in 2016. In this interview, he talks about his first experiences with Transhumanism, immortality and the future of humanity.

By Marie-Louise Timcke und Paul Klur

Why is Transhumanism important for our society nowadays?

Zoltan Istvan: Well, Transhumanism is perhaps the most important subject matter that we have actually existing in society at the moment. Because humankind has been moving forward very slowly developing science and technology. But in ways that haven’t really rudimentary changed the human being. But all of a sudden, since the invention of the microchip, humanity is changing dramatically because of data, because of the internet, because of computers, because of smartphones. And what we have seen is almost nothing compared to what we’re going to see over the next ten or twenty years. Transhumanism is the field that wants to use science and technology to modify the human being and realise this kind of digitization of the actual self. But most importantly, the next ten years are going to be completely disruptive to whatever we thought it meant to be human beings.

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