#genetherapy #protein #biology #ageing
“Scientists create a chemical that can restore hair and give youthful energy,” the Daily Mail reports. FOXO4-DRI, a modified protein, has been successfully used to remove “broken ageing” cells. However, the research thus far has only been used with mice.
This study examined cells that have stopped dividing, called senescent cells. Senescent cells are believed to be responsible for ageing, along with age related diseases such as arthritis.
Giving Tuesday is two weeks away, on November 28th. As manufactured celebrations go, I think we could do far worse than a holiday that encourages philanthropy. While most people are basically well-meaning, and I think would agree in principle that support for medical research is to the common good, we all lead busy lives and need prompting.
So here is a prompt, to remind you that we are all still aging, that aging causes an enormous toll of suffering and death, and that, absent progress, you too will be one of the victims. To offer material support to the research groups that are working to treat the causes of aging is not just the most compassionate thing you can do for the millions suffering today, it is also in your self-interest for tomorrow. If you are organized enough to save for retirement, because it will make your life easier decades from now, then you should also be organized enough to help establish the new medical technologies that will reduce or eliminate the age-related disease that also lies ahead, waiting.
The most effective way to help make progress through charitable contributions is to give to the SENS Research Foundation or their allies such as the Methuselah Foundation. This year we have put out a call for SENS Patrons, people willing to pledge a monthly contribution to the SENS Research Foundation. Josh Triplett, Christophe and Dominique Cornuejols, and Fight Aging! have put up a $36,000 challenge fund to encourage new supporters, and we will match the next full year of your donations if you sign up before the end of 2017.
If you are a medical doctor and interested in an alternative career researching functional medicine and evaluating true rejuvenation therapies, this is for you!
Forever Healthy is a private non-profit initiative whose mission is to enable people to vastly extend their healthy lifespan and be part of the first generation to cure aging.
We support the development of rejuvenation therapies that undo the damage of aging by funding basic research, bringing together the world’s leading scientists at our Undoing Aging conference and helping startups that work on actual therapies for human use.
In addition, we are developing our ‘Personal Longevity Strategy’ which harnesses the enormous wealth of the world’s cutting-edge medical knowledge to empower people to make informed decisions about extending their healthy lifespan right now.
The plague death toll shows no sign of slowing as official figures reveal 165 have now lost their lives in Madagascar’s ‘worst outbreak in 50 years’.
Data shows a 15 per cent jump in fatalities over three days, with scientists concerned it has reached ‘crisis’ point and 10 countries now placed on high alert.
At least 2,034 people have been struck down by a more lethal form of the ‘medieval disease’ so far in the country off the coast of Africa, according to WHO statistics.
Dr. Holger #Strohm – #Negative #HealthEffect Of #Radioactive #Heavy #Metal #Plutonium #Poison From #Fukushima; #BioConcentration Into #Humans, Then #Recycling Through #Cremation And Medical #Waste #Incineration Through DNA Of Future #Generations http://www.agreenroadjournal.com/2013/08/dr-holger-strohm-fukushima-up-to-12000.html
In June, several dozen scientists flew to Big Sky, Montana, to discuss the latest in CRISPR research. They had a lot to talk about, given that CRISPR—a tool that allows scientists to cut DNA to disable genes or insert new ones—is currently the hottest topic in biology, mentioned in the same breath as pronouncements like “changing the world” and “curing humanity of disease.”
On the second day in Big Sky, a Japanese researcher named Osamu Nureki got up to play a short movie clip. “I was sitting in the front, and I just heard this gasp from everyone behind me,” says Sam Sternberg, who worked in the CRISPR pioneer Jennifer Doudna’s lab at the University of California, Berkeley. It was, he says, the biggest reaction to data he’s ever seen at a conference.
Nureki’s paper was published in Nature Communications Friday, and by early morning, the video that astonished the room in Big Sky was making the rounds on science Twitter, too. I watched it, still bleary-eyed from sleep, and I jolted awake immediately.
Well, it has been a super busy month due to the popularity of the new Kurzgesagt videos about aging, and we have seen a massive positive response from the audience to the ideas presented there.
At the time of writing, 116,000 people have liked the video so far, and a mere 963 people have disliked it, with almost 2 million total views to date. Once again, as in the previous video, the ratio of support versus opposition is massively in favor of doing something about aging.
This is most welcome, though it is not entirely unexpected. It is no surprise that the majority of people support continued health and the eradication of age-related diseases through the development of advanced medicines. If you have not seen both videos, we recommend that you take a few minutes to enjoy them today.
This sort of thing is rapidly going mainstream, and de Grey, if still a fringe thinker, seems increasingly less so. At the very least, medical science has progressed to the point where “negligible senescence” — eternal youth, more or less — is something it might be a good idea to start talking about before it is suddenly upon us without our having thought through the implications. As with most of the other miracle technologies that have turned our lives inside out over the past 100 years — rampant automation, nuclear power, virtual reality, artificial intelligence and so on — this one, as Shukan Gendai points out, has its dark side.
Is death inevitable? True, everyone born before Aug. 4, 1900, has proved mortal (the world’s oldest-known living person, a Japanese woman named Nabi Tajima, was born on that date). But the past is only an imperfect guide to the future, as the effervescent present is ceaselessly teaching us.
Must we die? We ourselves probably must. But our children, our grandchildren — or if not them, theirs — may, conceivably, be the beneficiaries of the greatest revolution ever: the conquest of death.
Researchers from Empa have developed a flexible material that generates electricity when stressed. In future, it might be used as a sensor, integrated into clothing or even implanted in the human body, for instance, to power a pacemaker.
Flexible, organic, thin – properties that aren’t usually associated with power plants or sensors. But a new material developed by Empa researchers is exactly that: a thin, organic, flexible film that generates electricity if stretched and compressed. This rubber film could be incorporated into control buttons, clothing, robots or even people, and monitor activities, record touches or generate electricity when stressed to power implanted devices such as pacemakers, for example.
Natural killer (NK) cells are lymphocytes, immune cells which have a powerful arsenal of cytotoxic weaponry that they can use against tumors.
Unfortunately, tumors protect themselves using a protective microenvironment that shields them from attack from NK cells. This microenvironment promotes tumor growth and survival and has an immunosuppressive effect that blunts the attempts of NK cells to infiltrate the tumor and destroy it. That was until now and this new discovery.
