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MhAX, or Microhomology-Assisted eXcision.


Gene editing has the power to completely reshape our world.

It promises everything from fixing the genetic faults that lead to disease, to destroying disease-causing microbes, to improving the nutrition of the foods we eat and even resurrecting extinct species like the wooly mammoth — all largely thanks to the genetic editing tool CRISPR, which has both popularized this work and made it possible.

Now, researchers in Japan have developed a new gene editing technique that uses CRISPR alongside a DNA repair system to modify a single DNA base in the human genome, with what the team’s press release calls “absolute precision.”

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Celularity, a leading U.S. biotechnology company, is seizing on an opportunity to use cells to target diseases. The CEO, Dr. Robert Hariri, says placenta can be used to augment longevity and immunity. https://www.celularity.com

Celularity’s Massively Transformative Purpose (MTP) is to harness the power of the living cell to augment biology, immunity and longevity.

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More than 200 artificial intelligence startups applied for Nvidia’s Inception contest, which seeks to identify the best AI startups. The company created the program to find new uses for its graphics processing units (GPUs), but it’s also hoping these startups will change the world.

So far, the company has identified more than 2,800 AI startups over the years through Inception. I listened to pitches from 12 finalists in a Shark Tank styled judging event last week. Each is competing to be one of three finalists to share the $1 million prize pool.

“We’re trying to enable our ecosystem of deep learning neural networks,” said Nvidia CEO Jensen Huang, as he introduced a panel of four judges. The 12 semi-finalists gave their 8-minute pitches, six finalists were selected, and the final winners will be picked at the company’s GPU Technology Conference on March 27 in San Jose, California. They ranged from AI for bionic arms to faster, cheaper, and more accurate magnetic resonance imaging (MRI) scans.

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A recent study gives insight into the #neurobiology of dying. Before the process of dying neurologists closely monitored patients with devastating #brain injuries following Do Not Resuscitate-Comfort Care orders. This gave key insights into the mechanisms and timing of events in the brain and the circulatory system during the dying process.

The objective of emergency treatment is to restore circulation to prevent #cerebral ischemia. #Cerebral ischemia is a condition that occurs when blood flow is restricted to the brain, which then causes the #death of brain tissue. Understanding the brain’s response to energy depletion can help us estimate how much time is available for resuscitation until irreversible damage has occurred. The goal is to develop methods that can prolong this window before irreversible damage takes place. Injury to central neurons begins only during the progressive and uncontrollable #depolarization of neurons called anoxic depolarization. This Anoxic depolarization “wave” is potentially reversible and typically starts 2 to 5 minutes after the emergence of severe ischemia. This marks the beginning of a toxic change within the neuron which eventually leads to irreversible brain injury.

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