Lifeboat Foundation: Safeguarding Humanity
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Category: biological

What we pay attention to shapes our opinions and views and our opinions and views shape our actions—well beyond clicks and taps on a screen.

But this is only the beginning. The internet and its enabling tools were the last great generation of technology. New generations are already making their presence known. In coming decades, technology will more compellingly seduce our attention, will escape its silicon-and-glass cage, will animate the inanimate, and even shape our biology.

The answer isn’t to do away with technology. There’s no putting the genie back in the bottle—nor should we want to. Besides negative outcomes, technology remains a powerful tool for good too. But as individuals, as a society, we need to become far more aware of how we interact with technology, to keep a closer eye on business incentives, and to consciously employ our tools in ways that firmly align with our goals.

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When and how did the first animals appear? Science has long sought an answer to this question. Uppsala University researchers and colleagues in Denmark have now jointly found, in Greenland, embryo-like microfossils up to 570 million years old, revealing that organisms of this type were dispersed throughout the world. The study is published in Communications Biology.

“We believe this discovery of ours improves our scope for understanding the period in Earth’s history when first appeared—and is likely to prompt many interesting discussions,” says Sebastian Willman, the study’s first author and a palaeontologist at Uppsala University.

The existence of animals on Earth around 540 million years ago (mya) is well substantiated. This was when the event in evolution known as the “Cambrian Explosion” took place. Fossils from a huge number of creatures from the Cambrian period, many of them shelled, exist. The first animals must have evolved earlier still; but there are divergent views in the on whether the extant fossils dating back to the Precambrian Era are genuinely classifiable as animals.

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The idea of terraforming Mars is a fascinating idea. … But just how long would such an endeavor take, what would it cost us, and is it really an effective use of our time and energy?

Ultimately, Yakovlev thinks that space biospheres could also be accomplished within a reasonable timeframe – i.e. between 2030 and 2050 – which is simply not possible with terraforming. Citing the growing presence and power of the commercial space sector, Yakovlev also believed a lot of the infrastructure that is necessary is already in place (or under development).

“After we overcome the inertia of thinking +20 years, the experimental biosphere (like the settlement in Antarctica with watches), in 50 years the first generation of children born in the Cosmos will grow and the Earth will decrease, because it will enter the legends as a whole… As a result, terraforming will be canceled. And the subsequent conference will open the way for real exploration of the Cosmos. I’m proud to be on the same planet as Elon Reeve Musk. His missiles will be useful to lift designs for the first biosphere from the lunar factories. This is a close and direct way to conquer the Cosmos.”

With NASA scientists and entrepreneurs like Elon Musk looking to colonize Mars in the near future, and other commercial aerospace companies developing LEO, the size and shape of humanity’s future in space is difficult to predict. Perhaps we will jointly decide on a path that takes us to the Moon, Mars, and beyond. Perhaps we will see our best efforts directed into near-Earth space.

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Circa 2011

There is a physical and electrical disconnect between the world of electronics and the world of biology. Electronics tend to be rigid, operate using electrons, and are inherently two-dimensional. The brain, as a basis for comparison, is soft, operates using ions, and is three-dimensional. Researchers have therefore been looking to find different routes to create biocompatible devices that work well in wet environments like biological systems. In an exiting new development, researchers from North Carolina State University have fabricated a memory device that is soft, entirely based on liquid-based matter, and functions well in wet environments — opening the door to a new generation of biocompatible electronic devices.

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To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

Researchers at the Department of Energy’s Oak Ridge National Laboratory used neutron scattering to identify key information to improve the effectiveness of drug inhibitors designed to block the virus’s replication mechanism. The research is published in the Journal of Biological Chemistry.

The SARS-CoV-2 virus, which causes the COVID-19 disease, expresses long chains of proteins composed of approximately 1,900 amino acid residues. For the virus to reproduce, those chains have to be broken down and cut into smaller strands by an enzyme called the main protease. The active protease enzyme is formed from two identical protein molecules held together by hydrogen bonds. Developing a drug that inhibits or blocks the protease activity will prevent the virus from replicating and spreading to other cells in the body.

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The result is a science park and university campus that offers degrees at all levels. It hosts more than 300 labs and advanced research equipment, such as the SOLEIL synchrotron. About 100 companies and 6 of France’s public research organizations, including the national research agency CNRS, have a presence there. That combination — of the university with national facilities — is powerful, says Price. The park accounts for an estimated 15% of France’s public and private research. About 30,000 people work or study at Saclay, and this is projected to rise to 80,000 by 2030.

The lab has no overall scientific project, and has added an extra layer of management, says Fayard, although he concedes that the coronavirus pandemic has complicated the lab’s first months. “I fear the lab will have to work hard not to fall between two stools — it is too big to be efficient, but not big enough to invest alone in major local infrastructures.”

But Oliver Brüning, a particle physicist at CERN, Europe’s particle physics lab near Geneva, Switzerland, who spent time working at LAL, says he thinks the new lab has greater weight and influence than did LAL alone.

Saclay’s second-largest lab, the Institute for Integrative Biology of the Cell (I2BC), covers five biology disciples, including structural, cell and genome biology. More than 700 people, employed by national research agencies and universities, work there. Director Frédéric Boccard says it is too soon to judge whether the Paris-Saclay model is a success for research. “But it is extremely promising.” Boccard adds that having a critical mass of technological equipment means that the lab has attracted collaborators from all over France and many other countries, including Germany, the United States and Russia.

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Here’s my latest video!

Calorie restriction (CR) is well known to extend average and maximal lifespan in a variety of animal models, but what about in people? In this video, I present evidence showing that CR slows biological aging, which suggests that CR will positively affect lifespan in people.

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The great powerful guppy can essentially evolve 10 million times faster than usual. Which could lead to humans evolving faster too leading to a biological singularity.

Although natural selection is often viewed as a slow pruning process, a dramatic new field study suggests it can sometimes shape a population as fast as a chain saw can rip through a sapling. Scientists have found that guppies moved to a predator-free environment adapted to it in a mere 4 years—a rate of change some 10,000 to 10 million times faster than the average rates gleaned from the fossil record. Some experts argue that the 11-year study, described in today’s issue of Science,* may even shed light on evolutionary patterns that occur over eons.

A team led by evolutionary biologist David Reznick of the University of California, Riverside, scooped guppies from a waterfall pool brimming with predators in Trinidad’s Aripo River, then released them in a tributary where only one enemy species lurked. In as little as 4 years, male guppies in the predator-free tributary were already detectably larger and older at maturity when compared with the control population; 7 years later females were too. Guppies in the safer waters also lived longer and had fewer and bigger offspring.

The team next determined the rate of evolution for these genetic changes, using a unit called the darwin, or the proportional amount of change over time. The guppies evolved at a rate between 3700 and 45,000 darwins. For comparison, artificial-selection experiments on mice show rates of up to 200,000 darwins—while most rates measured in the fossil record are only 0.1 to 1.0 darwin. “It’s further proof that evolution can be very, very fast and dynamic,” says Philip Gingerich, a paleontologist at the University of Michigan, Ann Arbor. “It can happen on a time scale that’s as short as one generation—from us to our kids.”

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Chemists studying how life started often focus on how modern biopolymers like peptides and nucleic acids contributed, but modern biopolymers don’t form easily without help from living organisms. A possible solution to this paradox is that life started using different components, and many non-biological chemicals were likely abundant in the environment. A new survey conducted by an international team of chemists from the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology and other institutes from Malaysia, the Czech Republic, the U.S. and India, has found that a diverse set of such compounds easily form polymers under primitive environmental conditions, and some even spontaneously form cell-like structures.

Understanding how life started on Earth is one of the most challenging questions seeks to explain. Scientists presently study modern and try to see what aspects of their biochemistry are universal, and thus were probably present in the organisms from which they descended. The best guess is that life has thrived on Earth for at least 3.5 billion of Earth’s 4.5-billion-year history since the planet formed, and most scientists would say life likely began before there is good evidence for its existence. Problematically, since Earth’s surface is dynamic, the earliest traces of life on Earth have not been preserved in the geological record. However, the earliest evidence for life on Earth tells us little about what the earliest organisms were made of, or what was going on inside their cells. “There is clearly a lot left to learn from prebiotic chemistry about how life may have arisen,” says the study’s co-author Jim Cleaves.

A hallmark of life is evolution, and the mechanisms of evolution suggest that common traits can suddenly be displaced by rare and novel mutations which allow mutant organisms to survive better and proliferate, often replacing previously common organisms very rapidly. Paleontological, ecological and laboratory evidence suggests this occurs commonly and quickly. One example is an invasive organism like the dandelion, which was introduced to the Americas from Europe and is now a commo weed causing lawn-concerned homeowners to spend countless hours of effort and dollars to eradicate.

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