City of Hope researchers may have found a way to sharpen the fastest, cheapest and most accurate gene editing technique, CRISPR-Cas9, so that it can more successfully cut out undesirable genetic information.
This improved cutting ability could one day fast-track potential therapies for HIV, sickle cell disease and, potentially, other immune conditions.
“Our CRISPR-Cas9 design may be the difference between trying to cut a ribeye steak with a butter knife versus slicing it with a steak knife,” said Tristan Scott, Ph.D., lead author of the study and a staff research scientist at City of Hope’s Center for Gene Therapy. “Other scientists have tried to improve CRISPR cutting through chemical modifications, but that’s an expensive process and is like diamond-coating a blade. Instead, we have designed a better pair of scissors you can buy at any convenience store.”
The first attempt in the United States to use a gene editing tool called CRISPR against cancer seems safe in the three patients who have had it so far, but it’s too soon to know if it will improve survival, doctors reported Wednesday.
The doctors were able to take immune system cells from the patients’ blood and alter them genetically to help them recognize and fight cancer, with minimal and manageable side effects. The treatment deletes three genes that might have been hindering these cells’ ability to attack the disease, and adds a new, fourth feature to help them do the job.
“It’s the most complicated genetic, cellular engineering that’s been attempted so far,” said the study leader, Dr. Edward Stadtmauer of the University of Pennsylvania in Philadelphia. “This is proof that we can safely do gene editing of these cells.”
Excellent lecture. Darwin’s turtle, sharks and clams 500 years old, talking about Liz Parrish at an hour and 8. And then a tour.
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This video is DR. BILL ANDREWS PRESENTATION & TOUR OF SIERRA SCIENCES ON OCTOBER 11TH, 2019. Brent Nally recorded, edited and produced this video. My apologies for the poor audio and camera work in the first few minutes. Infinite gratitude to Bill for opening up Sierra Sciences to us. Here’s a link to purchase IsaGenesis. You have to sign up first: https://getstarted.isagenix.com/VF234XXQV001
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SHOW NOTES:
0:20 Dr. Bill Andrews is introduced by John. 1:30 Who is Bill? Bill’s credentials & vast scientific contributions. Bill’s social media: https://facebook.com/telomere.bill.andrews ; https://linkedin.com/in/william-h-andrews-5455b45/ ; https://en.wikipedia.org/wiki/William_H._Andrews_(biologist) ; https://sierrasci.com/ ; https://www.youtube.com/channel/UCB9UFIxyD9VUHjuNQzpLzeA 7:52 Watch “The Immortalists” about Dr. Bill Andrews & Dr. Aubrey de Grey: https://theimmortalists.com/watch/? 8:45 Buy Bill’s 2 books: https://www.amazon.com/Bill-Andrews-Telomere-Basics-Curing/dp/0615949983/ref=sr_1_1?keywords=curing+aging&qid=1571900985&sr=8-1 & https://www.amazon.com/Telomere-Lengthening-Curing-Disease-Including/dp/0692830111/ref=sr_1_6?crid=16QR0PL53GAKQ&keywords=telomere+lengthening&qid=1571901085&sprefix=telomere+length%2Caps%2C216&sr=8-6 ; Brent’s book review of Telomere Lengthening: Curing all diseases including cancer & aging by Dr. Bill Andrews: https://youtube.com/watch?v=5ODN5DIMz6c&t=6s 9:00 What is aging? 10:30 When human aging is cured, everyone will consider aging a disease. 11:45 bad things happen when telomeres get short. 14:40 When cells divide, the telomeres get a little bit shorter (telomeres loose about 50–100 base pairs in humans with every cell division) because our cells lack the ability to replicate to the very end. 16:50 There’s nothing humans can currently do to stop telomere shortening in the long term. 17:50 progeria is a terrible disease where kids are born with short telomeres. 19:12 telomere length is directly correlated with almost every disease. 20:25 Use PubMed to do a meta-analysis of scientific peer-reviewed studies https://www.ncbi.nlm.nih.gov/pubmed/ 20:56 Dr. Bill Andrews: “What’s Real and What’s Not” https://www.youtube.com/watch?v=5MmglQ54fQ0&t=18s 22:44 The telomere shortening solution: telomerase 26:06 What happens if humans produce telomerase in all of our cells? 29:14 Humans — telomerase activators like IsaGenesis are probably lengthening some of the shortest telomeres but it’s not strong enough to reverse all aspects of aging yet. 31:20 the telomerase gene is repressed in all our cells except our reproductive cells. 32:05 Sierra Sciences high throughput robots detect products that bind to the repressor protein to remove the repressor protein which allows telomerase to be expressed more in the cell. 34:08 Tested 10,000+ natural products — identified 39 telomerase inducers! 34:53 Isagenix IsaGenesis 37:33 Sierra Sciences is screening again! 37:50 How to keep your telomeres long: yoga and meditation; don’t stress too much — have fun! 44:29 Prevent & Reverse Heart Disease by Dr. Caldwell Esselstyn. 45:10 https://www.greatfullgardens.com/ 46:43 https://whatsmyfoodintolerance.com/ 47:20 Brent’s interview with Dr. Sandy https://www.youtube.com/watch?v=ejIoPtou_SM&t=3s 48:30 Bill’s obsessed with curing human aging because he doesn’t want to miss out on the future. 50:17 Sierra Sciences celebrated 20 years in 2019. 50:38 Q&A 1:00:40 There’s no scientific peer-reviewed data that shows telomerase causes cancer. 1:03:55 https://www.youtube.com/watch?v=_2A2i3Jn63Y&list=PLtu25cFK_Oy5Libh2RLcfd-YGFit0dpVU&index=3 1:08:18 Brent’s interview with Liz Parrish https://www.youtube.com/watch?v=oBFTwGPaPr4&t=2s 1:12:24 There’s no such thing as competitors in the human longevity field. 1:18:32 Sierra Sciences tour begins 1:20:05 One of the most powerful microscopes to view things by light. 1:20:55 human cell culture room 1:22:27 refrigerators and freezers 1:23:08 yoga and exercise room 1:23:30 molecular biology lab room 1:24:40 gene engineering and electrophoresis room. 1:26:10 Rolls-Royce jet engine 1:27:10 cold room 1:27:27 PCR (Polymerase Chain Reaction) room — Bill shows how they test ingredients for telomerase activation using PCR 1:29:18 transition lab 1:32:10 robotics room 1:34:08 Warehouse, shipping, receiving, storage, gene therapy room. 1:36:10 Intro & exit music by: SoundSage
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Scientists have developed a new gene-editing technology that could potentially correct up to 89% of genetic defects, including those that cause diseases like sickle cell anemia.
The new technique is called “prime editing,” and was developed by researchers from the Broad Institute of MIT and Harvard, who published their findings Monday in the journal Nature.
Prime editing builds on powerful CRISPR gene editing, but is more precise and versatile — it “directly writes new genetic information into a specified DNA site,” according to the paper.
