Shutting the window is usually the last resort in mitigating environmental noise, at the expense of natural ventilation. We describe an active sound control system fitted onto the opening of the domestic window that attenuates the incident sound, achieving a global reduction in the room interior while maintaining natural ventilation. The incident sound is actively attenuated by an array of control modules (a small loudspeaker) distributed optimally across the aperture. A single reference microphone provides advance information for the controller to compute the anti-noise signal input to the loudspeakers in real-time. A numerical analysis revealed that the maximum active attenuation potential outperforms the perfect acoustic insulation provided by a fully shut single-glazed window in ideal conditions. To determine the real-world performance of such an active control system, an experimental system is realized in the aperture of a full-sized window installed on a mockup room. Up to 10-dB reduction in energy-averaged sound pressure level was achieved by the active control system in the presence of a recorded real-world broadband noise. However, attenuation in the low-frequency range and its maximum power output is limited by the size of the loudspeakers.