This review article extends previous scientific definitions of the biofield (endogenous energy fields of the body) to include nonclassical and quantum energy fields. The biofield is defined further in terms of its functional property to act as a resonance target for external forms of energy used as treatment modalities in energy medicine. The functional role of the biofield in the body’s innate self-healing mechanisms is hypothesized, based on the concept of bioinformation which, mediated by consciousness, functions globally at the quantum level to supply coherence, phase, spin, and pattern information to regulate and heal all physiologic processes. This model is used to explain a wide variety of anomalies reported in the scientific literature, which can not be explained by traditional biophysics and bioelectromagnetics.