Photo by Erin Ashford Yale University Principal Investigator: David Spiegel Research Team: Prof. Jason Crawford, Nam Kim, Venkata Sabbasani, Matthew Streeter The long-lived collagen proteins that give structure to our arteries and other tissues are continuously exposed to blood sugar and other highly reactive molecules necessary for life. Occasionally, …Glucosepane Crosslinks and Undoing Age-Related Tissue Damage.