Bacteria are fast evolving resistance to antibiotics, which is fast-tracking us to a future where our best drugs no longer work and simple infections become life-threatening once again. While new antibiotics are in the works, the bugs will eventually develop resistances to those too, so a longer term strategy might be to prevent them from evolving in the first place. A new study has found that bacteria use clever gambles to adapt – and showed how we could rig the game in our favor.