Lifeboat Foundation: Safeguarding Humanity
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Month: September 2018

A wonderfully written, very friendly essay on the discoveries, carrier and life of Prof Dr David Sinclair and of course on sirtuins, the epigenetic theory of aging, resveratrol, nicotinamide dinucleotide NAD+ and healthy aging.

Since my recent visit to the Harvard Medical School laboratory run by Australian geneticist David Sinclair, I’ve been struggling with a shamefully greedy impulse. How can I get my hands on the wonder molecules that Sinclair is trialling to amazing effect in mice, not only slowing down their ageing but reversing it? My fear of missing out has flared up since I learnt from Sinclair that he estimates at least a third of his scientific colleagues are taking some version of these “anti-ageing” molecules, just as he does, in the belief it will increase their health spans by as much as 10 years. This means not just having a chance at living an extra decade, but living it in good health, avoiding the age-related diseases and general frailty that can make those years harrowing.

It becomes difficult to remain impartial when a respected scientist tells you he will soon turn 50, does not have a single grey hair and, according to regular blood and genetic tests, has the biological age of 31.4, even though he’s a workaholic and doesn’t exercise much. Or that he likes to think his mother prolonged her life – post lung cancer, with only one lung – for 20 years by taking the molecules he gave her, and that his 79-year-old father, who has taken several different kinds of them for years, currently lists whitewater rafting and mountaineering among his hobbies. Sinclair’s wife, Sandra Luikenhuis, even gives these molecules to the family dogs. (Luikenhuis, who has a PhD in genetics from Massachusetts Institute of Technology, only began taking the molecules herself after she noticed the irrefutably positive effect they’d had on their pets.)

If all goes well, and these anti-ageing molecules live up to their promise, Sinclair and his family will be proof it’s still possible to be going strong on the other side of the private apocalypse each of us has to face, what Philip Roth famously called the “massacre” of ageing. Imagine if you could still be standing tall after the dust clears, not one of the walking wounded, not just surviving, but thriving.

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Apple just unveiled three new iPhones during its annual September press conference, the three phones we all expected to see Apple announce. But it also killed six models in the process, retiring the aging iPhone SE, iPhone 6 and 6 Plus, iPhone 6s and 6s Plus, and the iPhone X. While Apple won’t sell these particular phones in store, it doesn’t mean they’re just going to disappear. They may become even more attractive to buyers looking for used iPhone deals. But if you are going to buy one of the older phones, especially the iPhone 6 and iPhone 6s, make sure you verify the health of their batteries and replace them before Apple’s deal expires.

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Engineers at the University of Maryland have created a thin battery, made of a few million carefully constructed “microbatteries” in a square inch. Each microbattery is shaped like a very tall, round room, providing much surface area – like wall space – on which nano-thin battery layers are assembled. The thin layers together with large surface area produces very high power along with high energy. It is dubbed a “3D battery” because each microbattery has a distinctly 3D shape.

These 3D batteries push conventional planar thin-film solid state batteries into a third dimension. Planar batteries are a single stack of flat layers serving the roles of anode, electrolyte, cathode and current collectors.

But to make the 3D batteries, the researchers drilled narrow holes are formed in silicon, no wider than a strand of spider silk but many times deeper. The were coated on the interior walls of the deep holes. The increased wall surface of the 3D microbatteries provides increased energy, while the thinness of the layers dramatically increases the power that can be delivered. The process is a little more complicated and expensive than its flat counterpart, but leads to more energy and higher power in the same footprint.

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The Venus Project is looking for VR artists for their project, Check it out!

A new project at The Venus Project has been started and a team consisting of video game industry veterans has been formed for its development.

The VR (Virtual Reality) Simulator will give access for everybody with a VR set to dive into a 360° projection of a city according to The Venus Project’s designs and experience it from the inside.

Most wanted specialists are:

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An international consortium involving over 50 institutions has announced an ambitious project to assemble high-quality genome sequences of all 66,000 vertebrate species on Earth, including all mammals, birds, reptiles, amphibians, and fish. With an estimated total cost of $600 million dollars, it’s a project of biblical proportions.

It’s called the Vertebrate Genomes Project (VGP), and it’s being organized by a consortium called Genome 10K, or G10K. As its name implies, this group had initially planned to sequence the genomes of at least 10,000 vertebrate species, but now, owing to tremendous advances and cost reductions in gene sequencing technologies, G10K has decided to up the ante, aiming to sequence both a male and female individual from each of the approximately 66,000 vertebrate species on Earth.

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This video is the first in a two-part series discussing big data. In this video, we’ll be discussing the importance of data and the role, it has played in advancing humankind as well as the exponential rate of growth of data.

[0:29–4:19] — Starting off we’ll look at, how data has been used as a tool from the origins of human evolution, starting at the hunter-gatherer age and leading up to the present information age.

[4:19–7:48] — Following that we’ll discuss, the many statistics demonstrating the exponential rate of growth and future growth of data.

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A new study on adult neurogenesis and Alzheimer’s disease.

According to a study led by scientists at Massachusetts General Hospital, exercise-induced neurogenesis improves cognition in a mouse model of Alzheimer’s disease, yielding more benefits than drug-induced adult neurogenesis. The scientists were able to figure out the difference between the two types of induced neurogenesis and pharmacologically reproduce the same benefits provided by exercise [1].

Study abstract

Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer’s disease (AD) pathology. We found that exercise provided cognitive benefit to 5×FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic factor (BDNF). Neither stimulation of AHN alone, nor exercise, in the absence of increased AHN, ameliorated cognition. We successfully mimicked the beneficial effects of exercise on AD mice by genetically and pharmacologically inducing AHN in combination with elevating BDNF levels. Suppressing AHN later led to worsened cognitive performance and loss of preexisting dentate neurons. Thus, pharmacological mimetics of exercise, enhancing AHN and elevating BDNF levels, may improve cognition in AD. Furthermore, applied at early stages of AD, these mimetics may protect against subsequent neuronal cell death.

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Quantum particles can be difficult to characterize, and almost impossible to control if they strongly interact with each other—until now.

An international team of researchers led by Princeton physicist Zahid Hasan has discovered a state of matter that can be “tuned” at will—and it’s 10 times more tuneable than existing theories can explain. This level of manipulability opens enormous possibilities for next-generation nanotechnologies and quantum computing.

“We found a new control knob for the quantum topological world,” said Hasan, the Eugene Higgins Professor of Physics. “We expect this is tip of the iceberg. There will be a new subfield of materials or physics grown out of this. … This would be a fantastic playground for nanoscale engineering.”

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But Dr Oransky and colleagues are also calling for better peer review after research is published.

“We should reward people who come forward about problems in other people’s work, not in a punitive way, but actually looking at it and saying, ‘hey, that’s a problem, we should do something about it’, and give people the chance to correct the record,” he said.

In China, there’s a growing black market peddling fake research papers, fake peer reviews, and even entirely fake research results to anyone who will pay. Does the rise of fake and fraudulent science threaten the future of research?

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