Caloric restriction has long been known to increase the lifespan and healthspan of most studied animals. Research also shows that animals given a calorie-restricted diet are also generally more able to regenerate tissue damage following injury.

Caloric restriction improves tissue regeneration

A new study by the Lengner lab at the University of Pennsylvania has identified the actual cells responsible for this increased regenerative capacity in intestinal tissue[1]. The researchers found that when a mouse given a calorie-restricted diet is exposed to radiation, a specialized type of stem cell known as a reserve stem cell is able to survive and rapidly repair intestinal tissues.