Lifeboat Foundation: Safeguarding Humanity
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Dear Lifeboat Readers,

I am a member of the Neuroscience Scientific Advisory Board at the Lifeboat Foundation and have recently posted to the BioPreserver Program page (please read the page replicated below).

I would like to initiate a conversation about expending more effort on preserving other species and their habitats. We are all understandably concerned about humanity’s survival and the Lifeboat Foundation is a testament to the numerous technologically advanced ways we can ensure our species’ survival in the future. However, I would like to hear from others who may be concerned that in our focus on our own survival we may not be doing enough for the myriad of other species with whom we share the planet. I would argue that there is less attention paid to the survival of our species’ moral integrity than there ought to be. Would it speak well of our species if we survived while everyone else (other species) disappeared? To put it bluntly, in the future, after having escaped numerous threats to survival, will we be able to look in the mirror as a species and like what we see?

For instance, with the current rate of losses, our closest living relatives, the chimpanzees, will be extinct in the wild in 50 years. The causes are indisputably anthropogenic. If we let this happen, what will it do to the morale and the psychological fiber of our species? The question of survival is not only a question of physical and psychological survival, but also survival of our integrity.

And while efforts to preserve the DNA of threatened species are laudable and important, they should not lull us into complacency about the future for other species.

With this said, I would like to propose discussing ways that the Lifeboat Foundation can apply more of its resources and talents to ensuring that there is enough room in the lifeboat for the other “nations of species” with whom we share the planet.

I look forward to your comments and ideas. Thank you, Lori Marino

BIOPRESERVER PAGE

We are currently in the midst of the sixth great mass extinction event in our planet’s history. The die-off of species is occurring at 100 to 1000 times the natural background rate and is largely due to human activities. At the current rate of die-off 1 in 4 mammals (and numerous other animal groups) will be gone in thirty years. All life forms, and especially animals, are complex organisms that thrive in a highly intricate dynamic milieu with each other and the planet’s ecosystems and this situation may limit our ability to respond once species do meet extinction.

Therefore, we also support efforts to preserve and protect the continued existence of endangered animals before they reach the endpoint of extinction. This is a critical component to BioPreserver and an important parallel effort to The Frozen Ark Project by the University of Nottingham, Natural History Museum, Zoological Society of London, and others to collect, preserve and store the DNA and viable cells from animals in danger of extinction.

We acknowledge the probability that once species are extinct it will be more difficult to reinstate their presence in the future. Although DNA preserves the genetic template of any given species it does not preserve the way these genetic instructions unfold in the physical, social and psychological context to yield the whole animal in all of its essence. Therefore, we support the joint effort to preserve both crucial genetic material of endangered animals and their present lives and habitats.

The US-led effort to expand the military BMEWS (ballistic missile early warning radar system) to Poland and the Czech Republic provoke Russian military strategists. Putin has proposed using their already operative radar base in Azerbajian (See “Azeri radar eyed for US shield”, BBC) in exchange for information from the US system. The US/NATO proposed TMD (theater missile defense) will also integrate early warning systems for short-range missiles in southern Europe. Is the race for space awareness and the weaponization of space inevitable?

The justification for the missile shield is the potential threat of long range missiles from Iran and North Korea (See “N-Korea test fires missile”, BBC). Military experts predict that with the current progress of nuclear research and missile technology available to Iran they will pose a threat to the US in 2015. NATO and Russia co-operate in certain military matters through the Russia-Nato Council but has increasingly been in conflict over the Iranian nuclear program and the European missile shield. (See “Russia-NATO: A marriage of convenience”, RIA Novosti). Russia has also demonstrated the ineffectiveness of the missile shield by launching their RS-24 multiple missile system carrying 10 warheads (See “RS-24 Missiles to replace old systems within next few years”, Interfax).

Terrestrial radars need to be complemented by satellites to keep track of missile launches across the planet (so called “boost phase interceptors”, see “Missile defense, satellites and politics”, The Space Review) to ensure complete space awareness. The Chinese Space Agency tested an anti-satellite missile earlier this year (See “Pentagon says China’s anti-satellite test posed a threat to nations”, AP). The move towards a hot space war could be imminent. The official press release was the only information given from Chinese authorities. The secrecy surrounding space capabilities was recently challenged by French authorities when they discovered 20–30 unregistered US surveillance satellites. (See “French says ‘non’ to U.S. Disclosure of Secret Satellites”, Space.com).

The race for the control of space is threatening to destabilize established military power structures. Secrecy is not the way of solving imbalances in international relations. Space is a part of the “commons” and should be dealt with accordingly. I propose an open source approach to the space awareness problematique. There are several approaches to distributed space awareness, e.g. launching private satellites for surveillance and distribution of real-time satellite imagery in order to counter a military space race. The alternative is a UN led control organization like the IAEA.

Other organizations like the Lifeboat Foundation could also play an important role in developing a threat reduction system for the ongoing cold space war.

Vladimir Putin is acting pretty crazy these days. The latest is that he is threatening to point nuclear missiles at Europe because the US is planning to install a missile defense system in Poland. How will this make Europe less inclined to have a missile defense system..? From CNN:

Speaking to foreign reporters days before he travels to Germany for the annual summit with President Bush and the other Group of Eight leaders, Putin assailed the White House plan to place a radar system in the Czech Republic and interceptor missiles in neighboring Poland. Washington says the system is needed to counter a potential threat from Iran.

In an interview released Monday, Putin suggested that Russia may respond to the threat by aiming its nuclear weapons at Europe.

“If a part of the strategic nuclear potential of the United States appears in Europe and, in the opinion of our military specialists, will threaten us, then we will have to take appropriate steps in response. What kind of steps? We will have to have new targets in Europe,” Putin said, according to a transcript released by the Kremlin. These could be targeted with “ballistic or cruise missiles or maybe a completely new system” he said.

As a Russian-American myself, I am appalled and disappointed that Putin’s anti-Americanism has reached the point where he feels he has to threaten Europe with nuclear attack because the US is planning to install a missile defense system there. All I can do is take pleasure in the fact that Putin has stated he will step down within the year, and pray that the next person to hold his office doesn’t behave like a gangster on the world stage.

The European Commission is funding a 2-year, $312,000 study on the safety and ethical aspects of synthetic biology. From the introduction part of the site:

We will pursue our objectives by means of a fact-finding mission, contribution to the European “inaugural” Conference on Synthetic Biology in Zurich (SB 3.0), an open e-forum and an international workshop. The foreseen impact of our project will be no less than to stimulate a European debate on these issues at an early stage. Past experiences, especially in the field of GM-crops, have shown the importance of an early bio-safety and ethics debate. The community recognized this need, but up to now discussions are fragmentary. Our project aims to stimulate a European debate in a proactive way. That way we will contribute to the European synthetic biology community, supplementing genuine biosafety and bioethics aspects.

Looks like a great start on addressing a very important area of concern. For a blog post of mine that goes into a bit more detail on the issue of synthetic biology and its risks, see here.

Five evolutionary stages of pathogen progression from animals to human transmission have been identified A proposed monitoring system of viral chatter has been proposed to provide warning of new diseases before they spread to humans.

In 1999, Wolfe began field work in the jungles of Cameroon to track “viral chatter,” or the regular transmission of diseases from animals to people, usually without further spread among humans. By monitoring the habits and the blood pathologies of bushmeat hunters and their kills, Wolfe and his team have identified at least three previously unknown retroviruses from the same family as HIV, as well as promoted safe practices for handling animals and animal carcasses.

“The Cameroon project demonstrated that it’s possible to collect information on viral transmission under very difficult circumstances from these highly exposed people,” Wolfe said.

With Cameroon as a prototype and a $2.5 million National Institutes of Health Pioneer Award as seed money, Wolfe has gone on to create a network of virus-discovery projects that monitor hunters, butchers, and wildlife trade and zoo workers in some of the world’s most remote viral hotspots. The network of a dozen sites in China, the Democratic Republic of Congo, Malaysia, Laos, Madagascar and Paraguay include source locations for such emerging diseases as SARS, avian flu, Nipah, Ebola and monkeypox.

There are more details of the five stages and a proposed study of the detailed origins of disease.

Wolfe and his colleagues begin by identifying five intermediate stages through which a pathogen exclusively infecting animals must travel before exclusively infecting humans. The research team identifies no inevitable progression of microbes from Stage 1 to Stage 5 and notes that many microbes remain stuck at a specific stage. The journey is arduous, and pathogens rarely climb through all five stages:

Stage 1. Agent only in animals: A microbe that is present in animals but not detected in humans under natural conditions. Examples include most malarial plasmodia.

Stage 2. Primary infection: Animal pathogens that are transmitted from animals to humans as a primary infection but not transmitted among humans. Examples include anthrax, rabies and West Nile virus.

Stage 3. Limited outbreak: Animal pathogens that undergo only a few cycles of secondary transmission among humans so that occasional human outbreaks triggered by a primary infection soon die out. Examples include the Ebola, Marburg and monkeypox viruses.

Stage 4. Long outbreak: A disease that exists in animals and has a natural cycle of infecting humans by primary transmission from the animal host but that also undergoes long sequences of secondary transmission between humans without involvement of animals. Examples include Chagas disease, yellow fever, dengue fever, influenza A, cholera, typhus and West African sleeping sickness.

Stage 5. Exclusive human agent: A pathogen exclusive to humans that involves either an ancestral pathogen present in a common ancestor of chimps and humans or involves a more recent pathogen that evolved into a specialized human pathogen. Examples include HIV, measles, mumps, rubella, smallpox and syphilis.

In addition, the team examines 25 diseases of important historic consequence to humans. Of the 25 diseases, 17 impose the heaviest world burden today: hepatitis B, influenza A, measles, pertussis, rotavirus A, syphilis, tetanus, tuberculosis, AIDS, Chagas disease, cholera, dengue hemorrhagic fever, East and West African sleeping sicknesses, falciparum and vivax malarias, and visceral leishmaniasis.

Eight more imposed heavy burdens in the past but have been reined in or eradicated thanks to modern medicine and public health practices: temperate diphtheria, mumps, plague, rubella, smallpox, typhoid, typhus and tropical yellow fever. Except for AIDS, dengue fever and cholera, most of the 25 have been important for more than two centuries.

The research team considered the varied pathologies of diseases originating in temperate (15) versus tropical (10) regions, as well as differing pathogen and geographic origins. Among the conclusions:

– Most of the temperate diseases, but none of the tropical diseases, are so-called “crowd epidemic diseases,” occurring locally as a brief epidemic and capable of persisting regionally only in large human populations. Most of the diseases originating in temperate climates convey long-lasting immunity.

– Eight of the 15 temperate diseases probably or possibly reached humans from domestic animals, three more from apes or rodents, and the other four came from still unknown sources. Thus the rise of agriculture, starting 11,000 years ago, plays multiple roles in the evolution of animal pathogens into human pathogens.

– Most tropical diseases have originated in wild, non-human primates. These animals are most closely related to humans and thus pose the weakest species barriers to pathogen transfer.

– Animal-derived human pathogens virtually all arose from pathogens of other warm-blooded vertebrates plus, in two cases, birds.

– Nearly all of the 25 major human pathogens originated in the Old Word (Africa, Europe and Asia), facilitating the conquest of the New World. Chagas disease is the only one of the 25 that clearly originated in the New World, while the debate is unresolved for syphilis and tuberculosis.

–Far more temperate diseases arose in the Old World because far more animals that furnish ancestral pathogens were domesticated there. Far fewer tropical diseases arose in the New World because the genetic distance is greater between humans and primates in this part of the globe.

The conclusions of the review illustrate large gaps in the understanding of the origins of even established major infectious diseases. Almost all studies reviewed were based on specimens collected from domestic animals, plus a few wild animal species.

The researchers propose an “origins initiative” aimed at identifying the origins of a dozen of the most important human infectious diseases as well as a global early warning system to monitor pathogens emerging from animals to humans.

This work is relevant to the lifeboat bioshield

If humanity ever meets lifeforms beyond Earth (or discovers our solitude in our galaxy) one thing will be sure–galactic historians will remark how interesting it must have been living in the nuclear age that “we now enjoy” (assuming we survive of course).

Speaking of nuclear, it seems that some scientists are utilizing a new drug that is showing major promises of fighting against radiation exposure, ensuring that victims not only survive, but remain “semi-healthy” as well.

(Space War) But now researchers at Washington University School of Medicine in St. Louis report they have developed an agent that protects cells from the lethal effects of radiation, regardless of whether it is given before or after exposure.

Using this agent in mice, the investigators found that the treatment helped shield rapidly dividing cells that are most vulnerable to radiation-induced death, providing proof in principle that it is possible to fend off radiation damage, according to a study published in the April issue of Biochemical and Biophysical Research Communications.

The interesting aspect of this drug is that it can be applied not only before a potential radiation calamity, but afterwards as well. Despite the fact that this drug is intended for those living on our home world, this anti-radiation drug could enable us to actually live upon the lunar and Martian surface.

Although this drug is not a “cure all” for all of our radiation woes, it could represent the first step of us actually living upon other worlds.

In a report to be published in the peer-reviewed journal PLoS Computational Biology and currently available online, Sally Blower, a professor at the Semel Institute for Neuroscience and Human Behavior at UCLA, and Romulus Breban and Raffaele Vardavas, postdoctoral fellows in Blower’s research group, used novel mathematical modeling techniques to predict that current health policy — based on voluntary vaccinations — is not adequate to control severe flu epidemics and pandemics unless vaccination programs offer incentives to individuals.

According to the researchers, the severity of such a health crisis could be reduced if programs were to provide several years of free vaccinations to individuals who pay for only one year. Interestingly, however, some incentive programs could have the opposite effect. Providing free vaccinations for entire families, for example, could actually increase the frequency of severe epidemics. This is because when the head of the household makes a choice — flu shots or no flu shots — on behalf of all the other household members, there is no individual decision-making, and adaptability is decreased.

While other models have determined what proportion of the population would need to be vaccinated in order to prevent a pandemic, none of these models have shown whether this critical coverage can actually be reached. What has been missing, according to Blower, a mathematical and evolutionary biologist, is the human factor.

The human factor involves two biological characteristics, “memory and how adaptable people can be,” Blower said. “These characteristics drive human behavior.”

The model Blower’s team developed is inspired by game theory, used in economics to predict how non-communicating, selfish individuals reach a collective behavior with respect to a common dilemma by adapting to what they think are other people’s decisions. The group modeled each individual’s strategy for making yearly vaccination decisions as an adaptive process of trial and error. They tracked both individual-level decisions and population-level variables — that is, the yearly vaccine coverage level and influenza prevalence, where prevalence is defined as the proportion of the population that is infected. The individual-level model was based on the human biological attributes of memory and adaptability.

The Lifeboat Foundation has the bioshield project

The Oxford Research Group has published “Beyond Terror: The Truth About the Real Threats to Our World”. The report focus on the disproportionate attention given to terrorism compared to the imminent threat from environmental degradation. The report looks at climate change, competition over resources, “marginalisation of the majority world” and global militarisation.

Read the entire report here.

Carnegie Mellon researchers Keith Florig and Baruch Fischhoff offer simple, practical advice: on whether it is worth citizens’ time to stock supplies needed for a home shelter, how urgently should one seek shelter following a nearby nuclear detonation, and how long should survivors remain in a shelter after the radioactive dust settles.


“A number of emergency-management organizations recommend that people stock their homes with a couple dozen categories of emergency supplies,” said Florig of Carnegie Mellon’s engineering and public policy department. “We calculated that it would cost about $240 per year for a typical family to maintain such a stock, including the value of storage space and the time needed to tend to it.”

Their research also suggests that many families who could afford to follow the stocking guidelines might think twice about whether the investment was really worth it, given the low probability that stocked supplies would actually be used in a nuclear emergency.

They advocate simple rules for minimizing risk based on how far people are from the blast. If you are within several miles of the blast, there will be no time to flee and you will have only minutes to seek shelter. If you are 10 miles [downwind] from the blast, you will have 15 to 60 minutes to find shelter, but not enough time to reliably flee the area before the fallout arrives,” said Florig.

However, the prior advice would suggest that if you are 10 miles from the blast that you could move perpendicular to the direction of the fallout plume and get out of the way in under 15 minutes. Needing to move one mile for smaller bombs. So I would think 10–20 miles downwind is a judgement call, but 25 miles you should be able to get out of the way of the fallout plume.

Cities that quickly closed schools and discouraged public gatherings had fewer deaths from the great flu pandemic in 1918 than cities that did not, researchers reported on Monday. Experts agree that a pandemic of some virus, most likely influenza, is almost 100 percent certain. What is not certain is when it will strike and which virus it will be.

In Kansas City, no more than 20 people could attend weddings or funerals. New York mandated staggered shifts at factories. In Seattle, the mayor told people to wear face masks.

No single action worked on its own, the researchers found, it was the combination of measures that saved lives. Peak death rates can be 50% to eight times lower. St. Louis authorities introduced “a broad series of measures designed to promote social distancing” as soon as flu showed up. Philadelphia downplayed the 1918 flu.

Philadelphia ended up with a peak death rate of 257 people per 100,000 population per week. St. Louis had just 31 per 100,000 at the peak.

No good vaccine would be available for months, and drugs that treat influenza are in very short supply.

So experts are looking at what they call non-pharmacologic interventions — ways to prevent infection without drugs. They hope this can buy time while companies make and distribute vaccines and drugs.

Because the virus is spread by small droplets passed within about three feet (1 meter) from person to person, keeping people apart is considered a possible strategy.

The U.S. government flu plan calls for similar measures, including allowing employees to stay home for weeks or even months, telecommuting and closing schools and perhaps large office buildings.

The Lifeboat Foundation has a bioshield project