To date, paralysis resulting from spinal cord damage has been irreparable. With a new therapeutic approach, scientists from the Department for Cell Physiology at Ruhr-Universität Bochum (RUB) headed by Professor Dietmar Fischer have succeeded for the first time in getting paralyzed mice to walk again. The keys to this are the protein hyper-interleukin-6, which stimulates nerve cells to regenerate, and the way how it is supplied to the animals. The researchers published their report in the journal Nature Communications from 15 January 2021.
Spinal cord injuries caused by sports or traffic accidents often result in permanent disabilities such as paraplegia. This is caused by damage to nerve fibers, so-called axons, which carry information from the brain to the muscles and back from the skin and muscles. If these fibers are damaged due to injury or illness, this communication is interrupted. Since severed axons in the spinal cord can’t grow back, the patients suffer from paralysis and numbness for life. To date, there are still no treatment options that could restore the lost functions in affected patients.
Summary: Close adherence to the MIND and Mediterranean diets delayed the onset of Parkinson’s disease by up to 17.4 years in women, and 8.4 years in men.
Source: University of British Columbia.
A new study from UBC researchers suggests a strong correlation between following the MIND and Mediterranean diets and later onset of Parkinson’s disease (PD). While researchers have long known of neuroprotective effects of the MIND diet for diseases like Alzheimer’s and dementia, this study is the first to suggest a link between this diet and brain health for Parkinson’s disease (PD).
It can be done. And it can be done sooner than many realise…even within YOUR lifetime. Imagine… Reaching triple digits with the health, fitness and body of an athletic 30 year old… It is entirely within reach now, it may be even less than a decade away. All we need to do is repair the damage that living and our metabolism create, it is slowly accumulating, which is why it takes 7 or 8 decades to rear its ugly head in most people, so one treatment should keep things under control for many years, and by then science will have advanced immeasurably, improving the treatments to whole new levels… Then you can dream of reaching 4 digits…then 5…then 6… BUT You need to stay in good enough shape to last long enough to see the treatments perfected and available. So watch your diet, your mental and physical health, your weight, and look to use occasional fasting, and time restricted eating, along with saunas and cold showers (or any hot/cold therapy), etc., to keep yourself at your optimum until that days arrives. If you want to know more, then this video breaks it down into even more detail. Have a great day and enjoy your journey into the future…
In a roadmap to end aging — understand the hallmarks to change your direction.
Getting old, grey hair, wrinkles, less strength, fragile bones, slower healing… And these are just the visible obvious factors, a slow continual decline towards your final grave. But if you know what is at fault, you can start to make lifestyle changes to alter their trajectory. Watch this video on Stress to find out more about what you can do and why it works https://youtu.be/s17UP_Ia4pQ And we do not only know what is happening, we also have some very good ideas of how to reverse, or at least, slow their decline whilst science works on real solutions. So, this will show you what the problems are, and then we shall start looking at what YOU can do to turn back the clock. With an aging population the benefits of more living their extended years in good health and able to lead whatever lifestyle they desire, is taking on ever more importance. Once you understand the mechanisms and follow the processes you will be able to build a better lifestyle aimed at a long and enjoyable existence. What are you actively doing to extend your healthspan? And these are just the visible obvious factors, a slow continual decline towards your final grave.
But if you know what is at fault, you can start to make lifestyle changes to alter their trajectory.
Watch this video on Stress to find out more about what you can do and why it works.
And we do not only know what is happening, we also have some very good ideas of how to reverse, or at least, slow their decline whilst science works on real solutions.
So, this will show you what the problems are, and then we shall start looking at what YOU can do to turn back the clock. With an aging population the benefits of more living their extended years in good health and able to lead whatever lifestyle they desire, is taking on ever more importance.
Once you understand the mechanisms and follow the processes you will be able to build a better lifestyle aimed at a long and enjoyable existence.
“In their work, Hamiliton’s team found that the Dunkin Hartley guinea pig was a good candidate for a muscle aging model due to the animal’s tendency to develop osteoarthritis (OA) at a young age.”
There are many components to aging, both mental and physical. When it comes to the infrastructure of the human body—the musculoskeletal system that includes muscles, bones, tendons and cartilage—age-associated decline is inevitable, and the rate of that decline increases the older we get. The loss of muscle function—and often muscle mass—is scientifically known as sarcopenia or dynapenia.
For adults in their 40s, sarcopenia is hardly noticeable—about 3% muscle mass is lost each decade. For those aged 65 years and older, however, muscle decline can become much more rapid, with an average loss of 1% muscle mass each year. More importantly, sarcopenia is also marked by a decrease in strength, impaired gait, reduced physical activity, or difficulty completing everyday tasks.
The proportion of older adults aged 65+ is projected to more than double by the year 2060, driving research into the process of musculoskeletal decline. Researchers at Colorado State University’s Columbine Health Systems Center for Healthy Aging believe they have found an animal model that will help them better understand it and find ways to curtail the symptoms.
Aubrey David Nicholas Jasper de Grey is an English author and biomedical gerontologist. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics. Feel free to ask any related questions that you want Aubrey to try and answer!
Futurist Foundation is a non-profit organization with the goal to connect futurists and promote crowd-sourced projects in science, technology, engineering, mathematics & design.
Donate to Futurist Foundation — https://opencollective.com/future. Donate to SENS — https://www.sens.org/get-involved/donate/ Discord: https://discord.gg/u3JM2cu. Website: http://thefuturistfoundation.com. Our Other Links: https://linktr.ee/futuristfoundation.
0:00 Introduction. 2:30 Aubreys last 25 years & Starting at SENS 14:35 SENS in 2020 21:27 Will there be a cut off age when its too late to repair aging? 24:36 Elasticity & Glycation. 30:13 As a medical student how can I get involved in longevity research? 33:07 SENS projects Underdog & Oisin. 38:51 mRNA Gene Therapy. 42:10 Effect of Aging on the Neural System. 49:41 Aubreys thoughts on Hyberbaric Oxygen Therapy. 51:21 SENS experience with regulators. 53:42 How do we make life extension treatments affordable? 58:28 Longevity Escape Velocity & Aubreys Timeline. 1:02:57 Is cryonics the backup plan? 1:08:28 Donate to SENS & Futurist Foundation.
(MS) has been announced by a collaboration including BioNTech, with a study in mice showing great promise for improving symptoms and stopping disease progression.
Summary: Pyramidal cells in the CA2 region of the hippocampus are responsible for storing critical timing information.
Source: MIT
When we experience a new event, our brain records a memory of not only what happened, but also the context, including the time and location of the event. A new study from MIT neuroscientists sheds light on how the timing of a memory is encoded in the hippocampus, and suggests that time and space are encoded separately.
The trial plans to inject stem cells into the spinal cords of people declared clinically brain dead, with the ultimate goal of restarting brain activity.
Summary: 20% of glioblastoma brain cancers are fueled by overactive mitochondria. Researchers say these cases may be treatable by drugs currently under trial.
Source: Columbia University.
A new study has found that up to 20% of glioblastomas–an aggressive brain cancer–are fueled by overactive mitochondria and may be treatable with drugs currently in clinical trials.
