Lifeboat Foundation: Safeguarding Humanity
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Category: neuroscience

If you’ve ever watched someone experience virtual reality for the first time, you know it can involve screaming, flapping arms, and occasional falls.

On one level people know their bodies are safe on the stable chair, but as their minds are catapulted through outer space on a spaceship to Mars or beamed into a refugee camp in Syria —they can’t help but lose their grip on reality and go along for the ride.

In fact, our brains don’t even require photorealism for suspension of disbelief in VR. A choppy CGI rendition will cause our heart rates to increase and our palms to get sweaty when we’re riding a virtual roller coaster or standing on the edge of a virtual building looking at the ground 30 stories below.

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While smaller organisms such as nematode worms have been imaged before, a entire central nervous system has now been recorded for the first time in the fruit fly, drosophila melanogaster.

The video shows neural activity (yellow/red) throughout the entire central nervous system (grey) of a Drosophila larva.

Credit: Keller et al. Nature Communications See More.

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Last week, the FDA approved the first 3D-printed prescription drug, essentially validating the technology as a new heavyweight player in big pharma. “This may be the first truly mass manufactured product made by 3D printing,” said Dr. Michael Cima, a professor at MIT who helped invent the pill-printing technology back in 1997, in an email to Singularity Hub. “It’s revolutionary.”

The printed pill, SPRITAM levetiracetam, is a drug that fights many kinds of epileptic seizures. The brainchild of a little-known Ohio-based company Aprecia, SPRITAM is essentially an old drug ingredient packaged into a brand new, more effective delivery system. Unlike current formulations of the same drug, SPRITAM immediately dissolves upon contact with water and bursts into effect — a property obviously beneficial when trying to curtail sudden-onset seizure episodes.

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“A protein found in the blood of young animals called GDF-11 is inducing systemic rejuvenation effects on bone, muscle, heart, blood vessels, and brains of older animals.

“GDF” stands for growth differentiating factor. It functions to turn “on” senescent stem cells, which results in a restoration of youthful structure and function to senile tissues. This same protein (GDF-11) is found in young humans as well as animals.

Harvard, Stanford, and other universities are conducting remarkable studies showing age reversal in animal models. Researchers from these centers of medical innovation are optimistic that this approach might be applicable to humans.”

Reversing aging may be humanly possible. It may also be closer than you think.

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A universal therapy that targets mis-folded proteins is a very significant step forward if clinical trials in humans translate from animals. Obviously there is more work to be done but it this is the kind of technology we need in order to intervene against biological aging.

It is not hard to see that a therapy like this followed up by another that regenerates the brain eg, the Conboy Lab work by promoting neurogenesis could be a way to repair and restore the brain to healthy function.

A drug that breaks up different types of brain plaque shows promising results in animals and could prevent Alzheimer’s and Parkinson’s disease.

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You may remember neuroscientist Miguel Nicolelis — he built the brain-controlled exoskeleton that allowed a paralyzed man to kick the first ball of the 2014 World Cup. What’s he working on now? Building ways for two minds (rats and monkeys, for now) to send messages brain to brain. Watch to the end for an experiment that, as he says, will go to “the limit of your imagination.”

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