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Category: neuroscience

In recent years we have seen the move away from ‘politics as usual’. Non-traditional figures have entered the political arena to disrupt the typical entrenched narratives. The election and worldwide popularity of Jacinda Ardern, New Zealand Prime Minister just one example of a new kind of leader who prioritises national wellbeing and happiness in the belief that everything else will follow.

Brigadier General (Retired) Dr. Loree Sutton Next Mayor of New York City?

Brigadier General Dr. Loree Sutton, ex-army general, physician, LGBTQ, mental healthcare advocate, is a further example of a leader who attempts to bridge the gap between people and focus on wellbeing. She is a candidate who is bringing a centrist, holistic, “quality-of-life” based approach to rejuvenating and re-inventing one of the world’s major financial, technological, and cultural capitals, New York City. https://loreeformayor.nyc @NYC Mayor’s Office.

From brigadier general to new york city mayor?

Ira Pastor ideaXme life sciences ambassador interviews General Dr. Loree Sutton a retired military officer who served as a Brigadier General in the United States Army for over 20 years (one of only 15 female generals out of the 1.3 million soldiers serving in the Army) as well as a medical psychiatrist (for a period of time the Army’s highest-ranking), who was deployed to various locations including Saudi Arabia, Iraq, Kuwait, ad Egypt in support of the first Gulf War and other missions, and is a current candidate in the 2021 New York City mayoral election.

Ira comments: Over Dr. Sutton’s career she has been awarded Legion of Merit (a military award of the United States Armed Forces that is given for exceptionally meritorious conduct in the performance of outstanding services and achievements), as well as the Bronze Star Medal, Defense Meritorious Service Medal, and Order of Military Medical Merit. Dr. Sutton is also the founding director of the Defense Centers of Excellence for Psychological Health and Traumatic Brain Injury, and served as a special assistant to the Assistant Secretary of Defense for Health Affairs.

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Emotional dysregulation and anxiety are common in people at clinical high risk for psychosis (CHR) and are associated with altered neural responses to emotional stimuli in the striatum and medial temporal lobe. Using a randomised, double-blind, parallel-group design, 33 CHR patients were randomised to a single oral dose of CBD (600 mg) or placebo. Healthy controls (n = 19) were studied under identical conditions but did not receive any drug. Participants were scanned with functional magnetic resonance imaging (fMRI) during a fearful face-processing paradigm. Activation related to the CHR state and to the effects of CBD was examined using a region-of-interest approach. During fear processing, CHR participants receiving placebo (n = 15) showed greater activation than controls (n = 19) in the parahippocampal gyrus but less activation in the striatum. Within these regions, activation in the CHR group that received CBD (n = 15) was intermediate between that of the CHR placebo and control groups. These findings suggest that in CHR patients, CBD modulates brain function in regions implicated in psychosis risk and emotion processing. These findings are similar to those previously evident using a memory paradigm, suggesting that the effects of CBD on medial temporal and striatal function may be task independent.

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What has been shaping the human mind throughout the history of mankind? What is the difference between mind and consciousness? What links quantum physics to consciousness? What gives rise to our subjective experience? What drives our accelerating evolution?

If you’re eager to familiarize with probably the most advanced ontological framework to date or if you’re already familiar with the Syntellect Hypothesis which, with this series, is now presented to you as the full-fledged Cybernetic Theory of Mind, you should get this book two of the series which corresponds to Part II of The Syntellect Hypothesis: Five Paradigms of the Mind’s Evolution. This volume two contains some newly-introduced and updated material if compared with the originally published version and can be read as a stand-alone book. At the same time, it is highly recommended to obtain The Syntellect Hypothesis as the original coherent version of the same theoretical framework instead of waiting for all five books to come out and if you don’t need extra detailing.

Over the course of human history, from the first bonfire to today’s smartphones and hyperloops, we have designed tools, and tools designed us back by shaping our minds. Technology isn’t just something outside ourselves, it’s an innate part of human nature, like sex, sleeping or eating, and it has been a major driving force in evolution. Tool using, along with language, bipedalism, and cooking (quite literally) is essentially what has made us human.

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From the data, the GTEx team could identify the relationship between specific genes and a type of regulatory DNA called expression quantitative trait loci, or eQTL. At least one eQTL regulates almost every human gene, and each eQTL can regulate more than one gene, influencing expression, GTEx member and human geneticist Kristin Ardlie of the Broad Institute tells Science.

Another major takeaway from the analyses was that sex affected gene expression in almost all of the tissue types, from heart to lung to brain cells. “The vast majority of biology is shared by males and females,” yet the gene expression differences are vast and might explain differences in disease progression, GTEx study coauthor Barbara Stranger of Northwestern University’s Feinberg School of Medicine tells Science. “In the future, this knowledge may contribute to personalized medicine, where we consider biological sex as one of the relevant components of an individual’s characteristics,” she says in a statement issued by the Centre for Genome Regulation in Barcelona, where some of the researchers who participated in the GTEx project work.

Another of the studies bolsters the association between telomere length, ancestry, and aging. Telomere length is typically measured in blood cells; GTEx researchers examined it in 23 different tissue types and found blood is indeed a good proxy for overall length in other tissues. The team also showed that, as previously reported, shorter telomeres were associated with aging and longer ones were found in people of African ancestry. But not all earlier results held; the authors didn’t see a pattern of longer telomeres in females or constantly shorter telomeres across the tissues of smokers as previous studies had.

Not everyone is singing the project’s praises. Dan Graur, an evolutionary biologist at the University of Houston who often criticizes big projects like GTEx, tells Science the results are hard to parse and there was little diversity, with 85 percent of the tissue donors being white. He also was critical of the use of deceased donor tissue, questioning if it truly reflects gene activity in living humans. “It’s like studying the mating behaviour of roadkill.”

Other scientists say there’s much work to be done. The gene regulation map leaves many unanswered questions about the exact sequences that cause disease and how gene regulation systems work in tandem. Genomicist Ewan Birney, the deputy director general of EMBL, tells Science, “We shouldn’t pack up our bags and say gene expression is solved.”

A decade-long effort to probe gene regulation reveals differences between males and females, points to essential regulatory elements, and offers insight into past work on telomeres.

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Summary: Glial cells not only control the speed of nerve conduction, but they also influence the precision of signal transduction.

Source: University of Münster

For the brain to work efficiently, it is important that a nerve impulse arrives at its destination as quickly and as precisely as possible. It has been long been known that the nerve fibres — also known as axons — pass on these impulses. In the course of evolution, an insulating sheath — myelin — developed around the axons which increases the speed of conduction. This insulating sheath is formed by the second type of cell in the nervous system — the glial cells, which are one of the main components of the brain. If, as a result of disease, myelin is depleted, this leads to neurological disorders such as Multiple Sclerosis or Morbus Charcot-Marie-Tooth.

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Cutting calories significantly may not be an easy task for most, but it’s tied to a host of health benefits ranging from longer lifespan to a much lower chance of developing cancer, heart disease, diabetes and neurodegenerative conditions such as Alzheimer’s.

A new study from teams led by Scripps Research Professors Bruno Conti, Ph.D., and Gary Siuzdak, Ph.D., illuminates the critical role that temperature plays in realizing these diet-induced health benefits. Through their findings, the scientists pave the way toward creating a medicinal compound that imitates the valuable effects of reduced body temperature.

The research appears in Science Signaling.

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Magnetism offers new ways to create more powerful and energy-efficient computers, but the realization of magnetic computing on the nanoscale is a challenging task. A critical advancement in the field of ultralow power computation using magnetic waves is reported by a joint team from Kaiserslautern, Jena and Vienna in the journal Nano Letters.

A local disturbance in the magnetic order of a magnet can propagate across a material in the form of a wave. These waves are known as spin waves and their associated quasi-particles are called magnons. Scientists from the Technische Universität Kaiserslautern, Innovent e. V. Jena and the University of Vienna are known for their expertise in the called ‘magnonics,’ which utilizes magnons for the development of novel types of computers, potentially complementing the conventional electron-based processors used nowadays.

“A new generation of computers using magnons could be more powerful and, above all, consume less energy. One major prerequisite is that we are able to fabricate, so-called single-mode waveguides, which enable us to use advanced wave-based signal processing schemes,” says Junior Professor Philipp Pirro, one of the leading scientists of the project. “This requires pushing the sizes of our structures into the nanometer range. The development of such conduits opens, for example, an access to the development of neuromorphic computing systems inspired by the functionalities of the human brain.”

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For college students studying science, doing labwork as part of their classes is a vital way to learn research skills and better understand concepts from lectures.

That presents a challenge for schools that are operating remotely during the coronavirus pandemic — so some biology programs are mailing brains, eyeballs, and even entire fetal pigs to their students so they can dissect them at home.

At Lafayette College, neuroscience students enrolled in a physiology course recently received packages in the mail that contained preserved sheep brains, which are commonly chosen by schools due to their close resemblance to human brains. Then, neuroscientist and psychologist Luis Schettino — who, in the interest of transparency, was one of my professors when I attended Lafayette — guided his students over a video call as they dissected the brains.

Special delivery!

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