https://vimeo.com/506690395
This is “Whatabout 1: The future by Aubrey de Grey, gerontologist” by WHAT on Vimeo, the home for high quality videos and the people who love them.
Category: life extension
This is the SECOND PART of the interview with Harold Katcher in Modern Healthspan YouTube channel.
Dr. Harold Katcher is a professor of Biology at the University of Maryland. He has been a pioneer in the field of cancer research, in the development of modern aspects of gene hunting and sequencing. He carries expertise in bioinformatics, chronobiology, and biotechnology. Dr. Katcher is currently working in the capacity of Chief Technical Officer at Nugenics Research exploring rejuvenation treatments in mammals.
In May 2020 there was a paper published on biorxiv about the rejuvenation of rats by over 50%. We did a review of the paper which you can find linked to above. In this interview series we talk with Dr. Harold Katcher, one of the main authors of the paper about the experiment, the steps to get validation, commercialization and how the results fit into his theories of aging.
In this video we talk about how the results from the experiment will be validated in two third party labs. One of which will use Rhesus monkeys and the other, under Dr. Greg Fahy, will use dogs.
The paper can be found here https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.
If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan.
#HaroldKatcher #SteveHorvath #ReverseAging
Did you know, getting a bit cold from time to time can help you get fitter, live longer, reduce pain and discomfort and help you concentrate and feel great?
Whether it is cold showers, ice baths, swimming in open water or trying out cryotherapy, enduring the cold is becoming increasingly popular as a way to hack your body as an aid to longevity and a good health span.
And for a good reason.
It effects metabolism, heart rate, blood pressure and many biomarkers.
It improves pain tolerance and levels, your mood and energy levels.
It effects mitochondrial biogenesis and brown fat stores, even beiging previously white adipose tissue.
In fact, there are hardly any systems left untouched.
But it does have side effects as well, especially for those who have health issues, but they also have the most to gain.
If you want to get more detail then check out this video where I go into more depth looking at the subject and discuss the studies that have been done to assess the effects.
Have a great day.
In Cold Showers Pros And Cons — And Other Cold Therapies, I will be looking at the good, and the bad, when it comes to embracing cold therapies from cold water swimming and ice baths, through to cold showers and cryotherapy.
What are they all about?
How do they work?
Do they even work?
Are they dangerous?
If you want to know the answer to these and more then just watch this video.
And after yo have finished, why not try this one about the benefits of saunas… https://youtu.be/dTwOMjWnzhg As always the studies that I mentioned are linked here… ECT overview https://www.mayoclinic.org/tests-proc… view of treatment Electroconvulsive Therapy for Depression: A Review of the Quality of ECT versus Sham ECT Trials and Meta-Analyses https://connect.springerpub.com/conte… Scientific Evidence-Based Effects of Hydrotherapy on Various Systems of the Body https://www.ncbi.nlm.nih.gov/pmc/arti… Plasma Renin study https://www.ncbi.nlm.nih.gov/pmc/arti… Effects of long-term whole-body cold exposures on plasma concentrations of ACTH, beta-endorphin, cortisol, catecholamines and cytokines https://pubmed.ncbi.nlm.nih.gov/18382… Human physiological responses to immersion into water of different temperatures https://link.springer.com/article/10… The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue https://www.ncbi.nlm.nih.gov/pmc/arti… Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat Obesity https://www.ncbi.nlm.nih.gov/pmc/arti… Cold-induced vasoconstriction may persist long after cooling ends: an evaluation of multiple cryotherapy units https://www.ncbi.nlm.nih.gov/pmc/arti…
https://youtu.be/dTwOMjWnzhg.
As always the studies that I mentioned are linked here…
ECT overview.
https://www.mayoclinic.org/tests-procedures/electroconvulsive-therapy/about/pac-20393894
I realize this will step on a lot of toes, but, its time to accept that the AI will be what solves it.
Targeting aging may extend the average life expectancy more substantially than prevention or treatment of individual diseases.
For centuries, scientists have tried to work on formulas to extend human life. While scientific and medical advancements have pushed the average human life expectancy to 71 years worldwide, researchers are still trying to find out if it can be extended further. Now, a group of scientists is leaning on artificial intelligence (AI) to combine conventional medicine to treat diseases and prevent them to extend longevity.
Conventional medicine has been the go-to tool for scientists to treat diseases and effectively extend life expectancy. But it has limitations too. While it can treat diseases, it’s not very effective in detecting early signs of an ailment that can reduce life expectancy. But combining AI, fundamental research and medicine could bring about a change in the research of extending human life. Dubbed as Longevity medicine, the scientists — Alex Zhavoronkov, Evelyne Yehudit Bischof and Kai-Fu Lee — proposed a framework. Their article was published in the journal Nature Aging.
Dr Zhavoronkov is a computer scientist with a doctorate in biophysics. Bischof is a practicing doctor who is researching on aging and gerooncology at the University Hospital Basel in Switzerland. Lee is known for his expertise in AI.
Scientists have proposed an artificial intelligence-based framework that can analyze millions of parameters and help fight aging.
This is the first part of the interview with Harold Katcher in Modern Healthspan YouTube channel.
Dr. Harold Katcher is a professor of Biology at the University of Maryland. He has been a pioneer in the field of cancer research, in the development of modern aspects of gene hunting and sequencing. He carries expertise in bioinformatics, chronobiology, and biotechnology. Dr. Katcher is currently working in the capacity of Chief Technical Officer at Nugenics Research exploring rejuvenation treatments in mammals.
In May 2020 there was a paper published on biorxiv about the rejuvenation of rats by over 50%. We did a review of the paper which you can find linked to above. In this interview series we talk with Dr. Harold Katcher, one of the main authors of the paper about the experiment, the steps to get validation, commercialization and how the results fit into his theories of aging.
In this video we talk about the actual experiment and some of the results that Dr. Katcher and his team saw.
The paper can be found here https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.
If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan.
#HaroldKatcher #SteveHorvath #ReverseAging
Gearing up for the interview with Harold Katcher!
Epigenetic age reversed by 54%. Scientific trial by Horvath Clock.
In this video we will discuss a paper entitled “Reversing age: dual species measurement of epigenetic age with a single clock”.
The paper can be found here https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.
The paper is a preprint available on bioXriv on a study showing the reversal of age in rats through exchange of blood plasma. Blood plasma of older rats was exchanged for that of younger rats which lead to the older rats having a reduced epigenetic age and many improved biomarkers, including reduced inflammation.
The age of the rats’ tissue was assessed by Dr Steve Horvath using 6 separate clocks which covered individual tissue as well as a pan tissue clocks.
We will be releasing an interview with one of the authors of the paper soon, Dr. Harold Katcher and we wanted to provide a review of the paper first.
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If you would like to support our channel, we’d love a coffee…thank you!
https://www.buymeacoffee.com/mhealthspan.
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The international team of artificial intelligence experts and medical doctors propose a framework for the application of next-generation AI to extend human longevity.
Deep Longevity Ltd.
Mayo Clinic proof-of-concept study shows that removal of senescent cells in the hippocampus of mice leads to improved cognitive responses.
‘The Death of Death’ — David Wood and Jose Cordeiro.
“La mort de la mort — les avancées scientifiques vers l’immortalité” was published on 21st January 2021 and is available in bookshops throughout France, Belgium, Luxembourg, and Switzerland, as well as online — see e.g. https://www.amazon.fr/mort-avanc%C3%A9es-scientifiques-vers-limmortalit%C3%A9/dp/2875422200/
To mark the occasion of the publication, Sergey Young, Founder of the Longevity Vision Fund, asked a number of questions to the book’s co-authors, José Cordeiro and David Wood.
This conversation took place in English — the book itself is in French.