Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

Here’s my latest video!

Papers referenced in the video:

DNA methylation GrimAge strongly predicts lifespan and healthspan:
https://pubmed.ncbi.nlm.nih.gov/30669119/

GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality:
https://pubmed.ncbi.nlm.nih.gov/33211845/

Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies:
https://pubmed.ncbi.nlm.nih.gov/30475962/

Albumin is included as a biological age predictor:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175034/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861848/
https://pubmed.ncbi.nlm.nih.gov/30993509/

Age-related change data for albumin:
https://pubmed.ncbi.nlm.nih.gov/26071488/

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages:
https://www.nature.com/articles/s41467-020-17636-0

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Check out “How Watson Works here.”

Is it possible to live forever by using narrow AI that can perform faster and smarter than humans? Having a doctor give you the correct diagnosis and treatment plan only happens on average, 54% of the time, as the New England Journal of Medicine has pointed out. Having Watson instantly diagnose you with the correct diagnosis and treatment plan 95% of the time will become the new standard. Our crop of new personal medicine products such as continual internal diagnostics, synthetic immune systems, virtual assistants, and regenerative medicine will diagnose and stop sickness from ever occurring while constantly rebuilding and improving body and mind capabilities.

IBM has made a series of Watson computer systems so that any company can raise their industries products and services far beyond our human capability. IBM’s Watson was first featured to the public with its historic Jeopardy win over Ken Jennings and Brad Rutter the best human Jeopardy players. At the time, Watson contained 200 million pages of structured and unstructured content in a ninety server computing system with an analytical software IBM designed called DeepQA. Now, the financial markets, medicine, insurance companies, government, engineering, and customer service call centers are employing (buying) Watson is an artificial intelligence system, that can be specifically tailored to any digitized industry and quickly evolve their industries potential.

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Summary: It’s not only our genetics and environment that play a role in aging and longevity, it’s also the random, tiny changes that arise on the cellular level.

Source: USC

A new model of aging takes into account not only genetics and environmental exposures but also the tiny changes that randomly arise at the cellular level.

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Earth is destined for disaster. This is a good insurance policy.

In 2013, a cataclysmic meteor the size of a six-story building broke apart above Chelyabinsk, Russia, and the resulting blast was stronger than a nuclear explosion. In 2068, astronomers believe a potentially hazardous “God of Chaos” asteroid could slam into Earth. Both events suggest humans—and every other animal and plant on Earth—are much more susceptible to total annihilation than we think.

That’s why scientists at the University of Arizona are proposing a far-out concept that just might save us all: a 21st-century version of Noah’s Ark … on the moon.

This ark wouldn’t contain two of every animal, but rather, a repository of cryogenically frozen reproductive cells from 6.7 million species on our planet.

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The hematopoietic (blood-forming) stem cells (HSCs) residing in our bone marrow produce all of our blood cells, including key immune cells that protect us from bacteria and viruses. As we age, our HSCs become less efficient and less able to make healthy new blood cells. In a study published online today in Nature, researchers at Albert Einstein College of Medicine have found that this reduction in HSC efficiency is caused in part by the deterioration of chaperone-mediated autophagy (CMA), the housekeeping process that removes damaged proteins and other waste materials that interfere with cells’ ability to function.

“While the aging of HSCs in our bone marrow is inevitable, the good news is that it may be reversible,” said co-study leader Ana Maria Cuervo, M.D., Ph.D., professor of developmental and , of anatomy and structural biology, and of medicine, and the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases at Einstein. “Our studies in mice suggest that drugs we’ve developed at Einstein can activate CMA and potentially restore the vitality of HSCs in older people.”

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“This is a fascinating study of gut microbiome in older adulthood,” wrote Barbara Bendlin from the University of Wisconsin, Madison. “While the investigators did not look at brain health or cognitive outcomes, it’s interesting to see that they found that healthy aging was accompanied by gut microbiomes that became increasingly more unique to each person starting in middle age. This type of divergence is also observed in brain aging.” (Full comment below.)

Past studies have shown that the gut microbiome undergoes rapid changes in the first three years of life, followed by a longer period of relative stability, then more change once again in later years (Yatsunenko et al., 2012; O’Toole and Jeffery, 2015). Research has also found that centenarians have fewer of the gut microbes commonly seen in younger, healthy people. Instead, they live with an increasingly rarefied microbiota (Kim et al., 2019). This suggests that gut microbiomes become increasingly personalized as people get older, but little is known about how these gut profiles affect the aging process or longevity.

To find out, first author Tomasz Wilmanski and colleagues analyzed gut microbiomes, personal traits, and clinical data from more than 9000 people 18 to 101 years old. They came from three independent cohorts. One was a group of 3653 people aged 18 to 87 who had signed up with Arivale, a now-defunct scientific wellness company co-founded by systems biology pioneer Leroy Hood and Price. Arivale provided personalized wellness coaching by collecting and analyzing data on participants’ genomes and other systems, including their gut microbiomes. Hood founded the Institute for Systems Biology.

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Creating 200 billion-plus brand-new red blood cells a day can take a toll on a body. The capacity to replace components charged with the life-sustaining task of carrying oxygen eventually wears out with aging, resulting in health problems, from anemia to blood cancers.

What if we could halt the aging process and maintain young blood cells for life? With blood cells making up a whopping 90% of the body’s cells, it makes sense that keeping them abundant and fit could boost vitality into our golden years.

Now, a group of researchers, including experts at the University of Colorado Anschutz Medical Campus, has discovered ways to do just that – keep the blood manufacturing process flowing. The work, recently published in the journal Nature, could open doors to everything from disease-preventive therapies to better blood banks.

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Rapamycin is the drug used to suppress the immune system after organ transplants, but in reduced doses, it appears it may have other health benefits and as such is discussed considerably in the longevity community, and taken regularly my some very famous proponents.

So I thought I would give you some background, alongside the pros and cons, to see what all the fuss is about…

Rapamycin Anti Aging.

Rapamycin is very popular in the anti aging paradigm so let’s have a look at what it is, what it offers, and what the trade offs are… because, well, it is always wise to have all the data.

If you want to know more about the hallmarks of aging I mentioned then check this out.

Links to studies mentioned.
Extension of chronological life span in yeast by decreased TOR pathway signaling.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356109/

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786175/

Unlike dietary restriction, rapamycin fails to extend lifespan.
https://onlinelibrary.wiley.com/doi/10.1111/acel.13302#.YCsRkk7C3I0.twitter.

Immune memory-boosting dose of rapamycin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119820/

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