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Category: life extension

The cells with hyper-long telomeres in these mice appear to be perfectly functional. When the tissues were analysed at various moments (0, 1, 6 and 12 months of life), these cells maintained the additional length scale (they shortened over time but at a normal rhythm), accumulated less DNA damage and had a greater capacity to repair any damage. In addition, the animals presented a lower tumour incidence than normal mice.

These results show that pluripotent stem cells that carry hyper-long telomeres can give rise to organisms with telomeres that remain young at the molecular level for longer. According to the authors, this “proof of concept means that it is possible to generate adult tissue with longer telomeres in the absence of genetic modifications”.

The Telomeres and Telomerase Group at the Spanish National Cancer Research Centre (CNIO), in collaboration with the Centre’s Transgenic Mice Core Unit, has succeeded in creating mice in the laboratory with hyper-long telomeres and with reduced molecular ageing, avoiding the use of what to date has been the standard method: genetic manipulation. This new technique based on epigenetic changes that is described today in the pages of Nature Communications, avoids the manipulation of genes in order to delay molecular ageing. The study also underlines the importance of this new strategy in generating embryonic stem cells and iPS cells with long telomeres for use in regenerative medicine.

Telomeres (the protective structures located at the ends of chromosomes) are essential to the stability of our genetic material and to maintain the “youthful state” of our and of our bodies. However, get shorter as we age. Once they reach a critical length, cells enter a state of senescence or die. This is one of the molecular causes of cellular ageing and of the emergence of ageing-related diseases.

On the other hand, when telomeres are extra-long — as achieved for the first time by the CNIO group headed by Maria A. Blasco using the expression of the telomerase gene — they exert a protective role against ageing and ageing-related diseases, thus significantly extending the lives of the mice.

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Scientists have long used NAD+ as a powerful anti-aging tool. While trying to find a cure for aging, scientists increased the levels of NAD+ within the mitochondria. The mitochondria responded by increasing their performance and energy, which effectively neutralizes the effects of aging.

Lead researcher Johan Auwerx explained that “this work could have very important implications in the field of regenerative medicine,” adding that it may one day be possible to bypass surgery and repair the body with a dietary supplement.

Specifically, nicotinamide riboside “effectively delayed early- and late-stage disease progression, by robustly inducing mitochondrial biogenesis in skeletal muscle and brown adipose tissue, preventing mitochondrial ultrastructure abnormalities and [mitochondrial DNA] deletion formation.”

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Let’s formulate the task of life extension slightly differently. Something like this…How can we extend sex appeal?

Gyms and beauty salons are in charge of this question now. There is some success, but it’s mostly superficial. Plastic surgery only masks, but doesn’t delay the processes of aging.

Expanding sex appeal is a complex task. Its aspects include both beauty and the activity of the brain. To be sexually attractive we have to be smart and fun. One cannot solve the problem of dementia with makeup.

We have to be in an excellent physical shape to be sexually attractive, but also things should be running smoothly with our hormonal regulation.

The task of extending the period of sex appeal is extremely science-intensive. It is not only the Viagra, but a complex impact on the whole organism. It is obvious that molecular biology is responsible for sex in the modern world.

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Here’s an article on transhumanism in Oregon’s largest paper, The Oregonian: It highlights something I’m trying to create: the impact of a “longevity vote” in the elections to make a difference for the length of people’s lifespans.

Zoltan Istvan is ready to encourage his supporters to vote for either Hillary Clinton or Donald Trump in November — if one of the major-party candidates agrees to put him to work in the White House.

And they’d better take his offer seriously, because he figures he just might be able to tip the election whichever way he wants.

“If we’re getting down to the end, and it’s close, as expected, this could be appealing to a candidate,” Istvan told The Oregonian this week. He believes he could bring a candidate somewhere between 250,000 and a million votes.

If neither Clinton nor Trump takes him up on his proposed deal, he’ll keep those votes for himself. Istvan, a former journalist, is the presidential candidate for the Transhumanist Party, which he created in 2014.

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MMTP Campaign update “Aging is a disease”.

Crowdfunding Campaign: https://www.lifespan.io/campaigns/the-major-mouse-testing-program/

We are testing a combination of compounds which clear out dysfunctional cells in the body, called Senolytics, to see if we can extend maximum lifespan and healthspan in mice. Please subscribe, share, and fund our Lifespan.io campaign today!

MMTP — Major Mouse Testing Program.
http://majormouse.org

Is a project by the International Longevity Alliance.
http://longevityalliance.org

Subscribe: https://www.youtube.com/user/LifespanIO

According to modern science, aging is the accumulation of damage that the body cannot completely eliminate, due to the imperfections of its protection and repair systems. The good news is that the processes that constitute aging are amenable to medical intervention. We can slow down or even reverse some aspects of aging by the application of different therapies, preventing or blocking some of these processes.

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Treatment with sex hormones recovers serious genetic diseases cells, this is the first demonstration that the lengthening of telomeres is possible in humans with the use of a medication,” says the researcher.

Estudo demostrou que há como estimular a enzima telomerase por meio de hormônios sexuais, tanto masculinos quanto femininos.

Por — Editorias: Ciências, Ciências Biológicas, Ciências da Saúde.

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Sea urchins are remarkable organisms. They can quickly regrow damaged spines and feet. Some species also live to extraordinary old ages and—even more remarkably—do so with no signs of poor health, such as a decline in regenerative capacity or an increase in age-related mortality. These ocean Methuselahs even reproduce as if they were still youngsters.

MDI Biological Laboratory Associate Professor James A. Coffman, Ph.D., is studying the of sea urchins in hopes that a deeper understanding of the process of regeneration, which governs the regeneration of aging tissues as well as lost or damaged body parts, will lead to a deeper understanding of the aging process in humans, with whom sea urchins share a close genetic relationship.

In a paper recently published in Aging Cell, a leading journal in the field of aging biology, with Andrea G. Bodnar, Ph.D., of the Bermuda Institute of Ocean Studies, the scientists shed new light on the aging process in sea urchins, raising the prospect that the physical decline that typically accompanies aging is not inevitable.

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