A new study published by scientists at the Salk Institute recently shows how that changes in the nucleolus of progeria cells and normally aged cells share some characteristics that may allow them to be used as a biomarker for biological age[1].
What is Progeria?
Hutchinson-Gilford progeria is a rare genetic disease that causes people to suffer from aging-like symptoms on an accelerated timescale compared to regular aging. Whilst it shares similarities with regular aging it is not accelerated aging per se, but the outcome is much the same.
Kurzweil is one of the world’s leading minds on artificial intelligence, technology and futurism. He is the author of five national best-selling books, including “The Singularity is Near” and “How to Create a Mind.”
Raymond “Ray” Kurzweil is an American author, computer scientist, inventor and futurist. Aside from futurology, he is involved in fields such as optical character recognition (OCR), text-to-speech synthesis, speech recognition technology, and electronic keyboard instruments. He has written books on health, artificial intelligence (AI), transhumanism, the technological singularity, and futurism. Kurzweil is a public advocate for the futurist and transhumanist movements, and gives public talks to share his optimistic outlook on life extension technologies and the future of nanotechnology, robotics, and biotechnology.
Kurzweil admits that he cared little for his health until age 35, when he was found to suffer from a glucose intolerance, an early form of type II diabetes (a major risk factor for heart disease). Kurzweil then found a doctor (Terry Grossman, M.D.) who shares his non-conventional beliefs to develop an extreme regimen involving hundreds of pills, chemical intravenous treatments, red wine, and various other methods to attempt to live longer. Kurzweil was ingesting “250 supplements, eight to 10 glasses of alkaline water and 10 cups of green tea” every day and drinking several glasses of red wine a week in an effort to “reprogram” his biochemistry. Lately, he has cut down the number of supplement pills to 90.
How do we make it in today’s crazy, alternative facts, almost alternative world–we get creative, we get INNOVATIVE. Here on ScIQ, we’re talking to two incredible innovators in medical sciences and human health.
Just in her 20s, Kathrine Jin was part of the team of Columbia University students who developed a low-cost, technology-driven solution to meet the urgent challenges posed by the Ebola crisis. She has been honored the United Nations in celebration of International Day of Women and Girls in Science for her part in the creation of Highlight, a patent-pending disinfectant solution. Learn more about Kinnos here: https://www.kinnos.us/about-us/
When he’s not working at MLB, Keith Comito works with his research group, LifeSpan I.O. in projects related to longevity or age related disease, and receive funds from contributors to fulfill their goals. Thanks to generous funding and awards towards life-changing research, Lifespan I.O. has currently completed 6 diverse projects, which you can find on Lifespan I.O’s website. Learn about Lifespan I.O here: https://www.lifespan.io/
This video is presented by Jayde Lovell, at Youtube Space NY. Written by Wandy Oritz, directed by Ingrid Nin, edited by Mashnoon Ibtesum at the YouTube Space NYC. Camera work by Alicia Weaver, Lisa McCullough, Genesis Moran and Mashnoon Ibtesum. Production Assistant: Jordan Yaqoob
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Great news! The AgeMeter campaign (https://www.lifespan.io/agemeter) has been extended by 2 weeks; partly because the project lead Elliott Small has been called in by FEMA to help with Hurricane Harvey. We are also happy to announce 2 sources of matching funds to help carry this important project to victory)!
Please check the campaign updates or our post for all the details: http://www.leafscience.org/fighting-aging-and-hurricane-harvey/
Using the power of artificial intelligence and machine learning the project is developing a free to use application to help speed up research and reduce animal suffering.
For more info and to find out how you can help please visit:
If there was a poster child of aging diseases, it would be Alzheimer’s disease. The brains of people suffering from Alzheimer’s disease have deposits of amyloids resulting from the loss of proteostasis. Alzheimer’s disease is accompanied by the presence of amyloid beta protein and tau protein as well as large numbers of activated pro-inflammatory immune cells.
The debate about which is primary has raged for many years in the research world, and it is still not clear how these three elements combine to cause disease progression. A new study has attempted to untangle the mystery and suggests the order is beta amyloid, inflammation, then tau, and this study identifies new targets for therapies[1].
Fantastic momentum so far on the MouseAge campaign, which raised over 10% of its goal on the first day! To learn more about how we are speeding up research and helping reduce animal suffering vist the campaign page:
A big thanks to Elena Milova, Thomas Klauset Aurdal, Jim Mellon (Juvenescence), James Joyce, Emanuele Ascani, Louie Helm, Martin Kleman, William DeVore, John D Gauchat, Peter Svensson, Poly Mamoshina, Felix Weimer, Reason (Fight Aging), Gennady Stolyarov (US Transhumanist Party). Alexey Strygin, Aleksandr Popov, Lars Christensen, Matthew Clarke and our Anonymous donors!
The old saying “use it or lose it” very much applies to reducing the impact that aging has on the mind and body. Of all the things we can do right now to help stay healthy as we grow older, exercise is probably the most useful.
Supplements have questionable results in humans, and none can really be described as geroprotective due to the lack of data. However, lifestyle and diet are very important in how we age, and caloric restriction has shown some interesting benefits in multiple species, including humans.
However, of all these things, exercise is probably the most important, and staying active can greatly influence our trajectory towards frailty in old age. Many people do not get the exercise they need as they age and, as a result, this can influence how well they age. Certainly, some level of age-related frailty may be a case of neglect and not exercising enough[1].
