Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

You probably know the quote by Steve Jobs saying that death is life’s single best invention because it gets rid of the old and makes room for the new. This view is the core of another fairly common objection to rejuvenation, codename “cultural stagnation”.

Wouldn’t all those rejuvenated people, however physically young, be always old people “inside”, and drag everyone down with them into their anachronistic, surpassed ways of thinking, making it harder for fresh ideas to take hold, ultimately hindering social progress and our growth as a species? Maybe it’d be best not to take the risk, forget rejuvenation, and be content with old age as it is.

Well, try explaining to your grandfather that the reason he has to put up with heart disease is that we’re afraid people his age may all become troublemakers when you let them live too long.

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Dr. Calos’s work has inspired us for over a decade: she has pioneered a radically novel approach to gene therapy that has the potential to overcome all the key obstacles that have held that field back for so long. We are delighted to welcome her to Berlin to discuss the latest advances in this technology.

https://www.undoing-aging.org/news/dr-michele-calos-to-speak-at-undoing-aging-2018

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Interesting article about the longevity work of my friend James Clement in The New York Times: https://nyti.ms/2hw8W32 #transhumanism

James Clement has scoured the globe for supercentenarians, aged 110 and older, willing to contribute their genomes to a rare scientific cache.

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It’s all a question of money. We should come up with enough money for funding this so that we can clone a perfect genetic match of every organ in the body by 2025. It will solve the organ shortage issue, and nip the illegal black market organ industry in the bud.

The FDA said it is looking into “regenerative medicine.”

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Today, we take a look at three key emerging technologies that might add extra healthy years to your life by addressing the aging processes directly to prevent or delay age-related diseases.

Senolytics – Removing aged dysfunctional cells to promote tissue regeneration

As we age, increasing amounts of our cells enter into a state known as senescence. Normally, these cells destroy themselves by a self-destruct process known as apoptosis and are disposed of by the immune system. Unfortunately, as we age, increasing numbers of these cells evade apoptosis and linger in the body.

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There are many benefits to exercise and how it can reduce the impact of the aging process. We have previously talked about how even a moderate amount of gentle exercise, such as walking, dancing, and strength training, can improve health and reduce mortality.

New research suggests that even moderate levels of physical activity can reduce glaucoma, one of the leading causes of blindness in the United States, and which is most prevalent among the elderly.

The data presented by UCLA researchers at the 121st Annual Meeting of the American Academy of Ophthalmology showed that the most physically active people involved in a recent study have a 73 percent reduced risk of developing glaucoma compared to the least active.

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Every so often when talking about aging and eradicating age-related diseases someone will say there are other more important things that must be solved before we earn the right to live healthy and longer lives.

When you discuss any major issue, sooner or later someone will say it: there are more urgent issues than whatever it is you’re advocating for. Sometimes it may be true; other times, and probably most of the time, it’s a logical fallacy known as appeal to worse problems (or “not as bad as”, or even “fallacy of relative privation”).

For example, say you’ve got two issues, A and B, that cannot possibly be both dealt with at the same time; if A is life-threatening and B isn’t, well, then I think it’d make sense to reply “there are more urgent issues” to whoever suggests B should be taken care of first. However, all too often, this answer is abused to play down the importance of a problem that doesn’t happen to be one’s personal favourite—and yes, I’ve seen this happen with rejuvenation therapies.

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How far off is age reversal?

The simple answer is, I don’t know. Probably we’ll see the first dog trials in the next year or two. If that works, human trials are another two years away, and eight years before they’re done. Once you get a few going and succeeding it’s a positive feedback loop.

George Church Will Make Virus-Resistant Organisms, Transplant Pig Organs to Humans, and Reverse Aging An interview with one of the most prolific scientists on earth in his lab at Harvard Medical School Photography by Maciek Jasik.

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A compound in dark chocolate and red wine could help rejuvenate cells, according to a scientific breakthrough.

Researchers from the Universities of Exeter and Brighton have made the sizeable breakthrough on ageing and discovered a way to rejuvenate inactive senescent cells.

They found that they could make the cells both look and behave like younger cells.

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