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Following heart attacks, a handful of monkeys regained some of the pumping ability their hearts had lost after being given human embryonic stem cells, according to a study published Monday in Nature Biotechnology.

Scientists have tried for years to develop a stem cell treatment for heart disease caused by lack of blood flow, which contributed to more than 9.4 million deaths worldwide in 2016, according to the World Health Organization.

“We’re talking about the number one cause of death in the world [for humans],” said study author Dr. Charles Murry, director of the Institute for Stem Cell and Regenerative Medicine at the University of Washington. “And at the moment all of our treatments are … dancing around the root problem, which is that you don’t have enough muscle cells.”

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Why on Earth would you ever want to be less than completely healthy?


Recently, Reason of Fight Aging! pointed out psychological research revealing a certain conservatism in terms of what people consider to be the “ideal” levels of happiness, intelligence, longevity, and even health.

It probably doesn’t come as a surprise that significant numbers of people in the studies weren’t too keen on the idea of living much longer than the average (around 90 years), and even under the assumption of eternal youth, their preference didn’t go past 120 on average; after all, LEAF wouldn’t be in business if the idea of healthy life extension wasn’t so inexplicably frowned upon. What’s really flabbergasting, though, is that even health—health!—is apparently something you can have too much of; on a scale from 0 (“completely unhealthy”) to 100 (“completely healthy”), the average preference gravitated somewhere between 80 and 90. These results provide us with an occasion for reflection.

(Il)logical conclusions

It’s uncertain whether the respondents in these studies realized the bizarre yet inevitable implications of their statements. If 100 means “completely healthy” and your “ideal” level of health is only, say, 85, does that mean that, should you ever perceive that you’re about “90” healthy, you’d deliberately start looking into ways of harming your own health to get back to your ideal level? How, exactly, would being “90” healthy be too much? What would you dislike about not being a little more sick? How would you benefit from being less than completely healthy? Has there ever been, at any point in your life, a moment when you thought, “Blimey, I’m far too healthy for my own good. Time to get sick”? Do you think a point will ever come when, while sick, you’ll think, “Perfect timing—I was just concerned that I was healthier than my ideal level”?

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Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued to grow at an ever-increasing pace. Now, there are many researchers engaged in exploring senescent cells and their role in aging and disease.

Lately, there has been enthusiastic interest in developing therapies to remove these problematic senescent cells, but are there potentially better ways to deal with senescent cells beyond periodically purging them with senolytic drugs and therapies?

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LEAF’s monthly rejuvenation roundup is out!


July is here, and our upcoming conference in New York City is only a handful of days away! If you haven’t done so already, go and get your ticket now so that you can enjoy the June roundup fully relaxed, knowing that your seat is secured.

About our NYC conference

On the off chance you’ve missed the news about it, Ending Age-Related Diseases: Investment Prospects & Advances in Research is our first conference to be held in New York City. It will take place on July 12th at Cooper Union, and it will feature talks and panels with several great speakers, such as Dr. Vera Gorbunova from Rochester University, Dr. Vadim Gladyshev from Harvard Medical School, Dr. Aubrey de Grey from SENS Research Foundation, Dr. Kelsey Moody from Ichor Therapeutics, and many more. You can get your ticket here, and remember that Lifespan Heroes get 75% off the ticket price!

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Senolytics developed by UNITY Biotechnology are currently in Phase-1 clinical trials.


Today we are pleased to announce that UNITY Biotechnology is going into human clinical trials with the first true rejuvenation therapy that directly targets one of the processes of aging: senescent cells.

The quiet revolution

In our collective imagination, revolutions start with a bang; however, more often than not, real-life technological revolutions start quietly and unbeknownst to most people. This is pretty much what’s going on with the therapies that aim to prevent or reverse age-related diseases by targeting the aging processes directly.

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The secret of life extension from vampires.


Getting older and dying is so inconvenient. Eating a healthy diet and exercising is a good start in warding off death, but if you’re looking to truly up your immortality game, the answer is simple: teen blood. For a whopping $8,000, the old and the wealthy can receive a blood transfusion from a teenager. Yes, you read that right.

At Ambrosia’s clinics in San Francisco and Tampa, Florida, the wrinkled are receiving what founder Dr. Jesse Karmazin simply refers to as a “young blood treatment.” Patients are administered a transfusion of around 0.66 gallons of blood acquired from donors between the ages of 16 and 25.

“It’s like an entire set of new blood,” Karmazin tells Inverse.

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Jeanne Louise Calment lived for 122 years and 164 days, the oldest verified age of any person, ever. Her interviews revealed a portrait of the centenarian in high spirits: “I’ve only ever had one wrinkle, and I’m sitting on it,” she told reporters when she turned 110.

Calment died in 1997 in Arles, France, where she spent much of her impressively long life. No one else, according to accurate records, has lived beyond 120 years.

Whether there’s a limit to the human life span is an age-old question. An actuary named Benjamin Gompertz proposed in 1825 that mortality rates accelerate exponentially as we grow older.

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An interview with regenerative medicine luminary Dr. Anthony Atala.


After meeting him at the Astana Global Challenges Summit 2018, we’ve kindly been granted an interview by Dr. Anthony Atala, M.D., Director of the Wake Forest Institute for Regenerative Medicine and the W. Boyce Professor and Chair of Urology at Wake Forest University.

Dr. Atala is one of the most influential names in the field of regenerative medicine and biotechnology. His research focuses on growing human cells and tissues for use in transplants, and given the constant dire need for organ donors worldwide, his work is poised to improve—and save—the lives of millions. He and his team have already successfully engineered and transplanted bladders into living patients, and as he’s told us himself, more types of tissue have been engineered and tested in models; hopefully, they will one day be usable in patients as well.

Dr. Atala’s groundbreaking work has earned him countless awards, prizes, and nominations in well-known magazines, such as Scientific American, Time Magazine, the Huffington Post, and many others; he has also served on the boards and committees of several organizations, such as the National Institutes of Health, the National Cancer Institute, and SENS Research Foundation. A more detailed biography of Dr. Atala can be found here.

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