Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension

Last month, researchers at Johan Auwerx’s lab at the Ecole Polytechnique Fédérale de Lausanne (EPFL) had looked at the connections between RNA-binding proteins and aging. RNA binding proteins (RBPs) play an important part in post-transcriptional control by binding to mRNAfter binding, RBPs can aid in the processing of pre-mRNA as well as mRNA stability, transport and translation [1].

Mitochondria

Upon screening aged animals for RBPs, researchers at the EPFL noticed increased activity of Pumilio2 (PUM2), which can lower the production of some proteins. It does this by binding to specific mRNAs (based on recognition sites) so that it can repress the translation of those mRNAs into proteins.

Read more

Longevity Vision Fund has exited stealth with plans to invest $100 million in startups with aspirations to extend healthy lifespans. The fund, which is linked to the founder of XPrize, will pump the money into biotechs and other longevity startups based around the world in seed to series B rounds.

Sergey Young, the founder of Longevity Vision, unveiled the fund at an event in London this week. Young is the cofounder of Peak State Ventures and an innovation board member at XPrize Foundation, a nonprofit known for running competitions to incentivize advances in fields including suborbital space flight.

At Peak State, Young and his colleagues invest in fields well outside of longevity, including property and education. But Young has established a foothold in the longevity space, leading to him becoming development sponsor of Longevity XPrize and a longevity partner at Bold Capital Partners.

Read more

Project fear? Should we pay attention to American Jesuits?

But the fundamental ambition of transhumanism is more problematic. Its architects champion a use of technology to accelerate the evolution of humanity so radically that at the end of the process humanity as such would disappear. A superior posthuman being would emerge. According to Wikipedia, “Transhumanism is the intellectual and cultural movement that affirms the possibility and desirability of fundamentally improving the human condition through applied reason, especially by developing and making widely available knowledge to eliminate aging and to greatly enhance human intellectual, physical, and psychological capacities.” From its inception, the abolition of human death and aging has been one of the goals of transhumanism as it engineers a new being freed from the biological constraints of the current human condition.

From its inception, the abolition of human death and aging has been one of the goals of transhumanism.

Two of the movement’s philosophers, Max More and David Pearce, have developed eloquent apologies for the transhumanist creed. But they also indicate the movement’s more ominous philosophical themes.

Read more

February 4th, 2019 saw the Longevity Leaders Conference hosted in Aldersgate, London. I was fortunate enough to have been invited to attend this interesting event, so I thought that today was the ideal time to share some experiences of the conference with you.

The conference was quite broad in scope and included people from the aging research community, the pharmaceutical industry, general healthcare, and the business and insurance fields.

Read more

Very excited to have interviewed Dr. Michael Lustgarten in my role as longevity / aging ambassador for the ideaXme Show — Mike has been at the forefront of studying the 100 trillion organisms present in the human microbiome, their effect on human health and wellness, as well as a major proponent of metabolomics and biologic age tracking — A true future thinker in the area of extending human lifespan and healthspan

“Ruth is a shining example of one of the qualities I most admire in a scientist: dogged perseverance in pursuit of one’s thesis, in spite of near-universal rejection of it by the mainstream community, until one finally wins them round.

It’s only an admirable quality if you’re likely to be right, of course, so you’d better be a really good scientist in other ways too — and she sure is. Ruth spoke at a couple of my Cambridge conferences and I was always dismayed that such solid data and logic concerning the involvement of herpes simplex virus in Alzheimer’s disease was so widely ignored or dismissed for what seemed to be totally flimsy reasons. That’s not happening any more!”, says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-ruth-itzhaki-to-speak-at-undoing-aging-2019

Read more

The longevity industry gets a boost with the launch of a $100 million venture fund, Longevity Vision Fund, focused on longevity biotechnology and artificial intelligence. The fund will invest in infrastructure projects enabling the longevity biotechnology industry.

Read more

An excellent article on Hackaday addresses the lifetime of LED bulbs. To a certain degree, it also addresses the lifetime of LED’s themselves. However, the majority of the article investigates the various parts of the LED bulb, such as electronics and housings, and how they last. The article also addresses the issues of lumen depreciation and color change.

These issues are all important when thinking about long-term use in space applications.

Early adopters of LED lighting will remember 50,000 hour or even 100,000 hour lifetime ratings printed on the box. But during a recent trip to the hardware store the longest advertised lifetime I found was 25,000 hours. Others claimed only 7,500 or 15,000 hours. And yes, these are brand-name bulbs from Cree and GE.

So, what happened to those 100,000 hour residential LED bulbs? Were the initial estimates just over-optimistic? Was it all marketing hype? Or, did we not know enough about LED aging to predict the true useful life of a bulb?

I put these questions to the test. Join me after the break for some background on the light bulb cartel from the days of incandescent bulbs (not a joke, a cartel controlled the life of your bulbs), and for the destruction of some modern LED bulbs to see why the lifetimes are clocking in a lot lower than the original wave of LED replacements.

Read more