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Category: life extension

For a core of longevity true believers, the time to intervene is now.

“How old are you?” James Clement wanted to know.

I turn 50 this year. There’s a new creaking in my bones; my skin doesn’t snap back the way it used to. It’s developed a dull thickness—you can’t tickle me at all. My gums are packing it in and retreating toward my jaw. These changes have been gradual or inexplicably sudden, like the day when I could no longer see the typed words that are my profession. Presbyopia, the ophthalmologist told me. Totally normal. You’re middle-aged.

To Clement, though, my age was great news. “Yep, you are going to live forever,” he said. “I think anybody under 50 who does not have a genetic liability will make it to longevity escape velocity.”

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A new study outlines multiple ways in which epiblast stem cells can be reprogrammed back into a fully pluripotent state, paving the way for a better understanding of epigenetics.

The role of epigenetics

Epigenetics are why our cells, which all have the same DNA, differ in function. A bone cell has the same genetics as a nerve cell, but its epigenetic switches instruct it to perform the functions of a bone cell and not a nerve cell. Epigenetic alterations, however, are one of the primary hallmarks of aging. As we age, harmful epigenetic switches are activated and beneficial ones are deactivated, causing age-related dysfunction. This may even lead to inflammation, which causes further epigenetic damage, leading to a dangerous feedback loop.

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The de Grey… AEWR.

Storytel, a monthly free trial: https://storytel.ru/bookperson
VK public page «Mustreads» where you can win the book «Ending Aging»: https://vk.com/mustreads
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Support the project on Patreon: https://patreon.com/mustreader

21 lessons for the 21st century by Yuval Noah Harari: https://amzn.to/2H6QN5u
Infinite Jest by David Foster Wallace: https://amzn.to/2Z8pHkq
The Fry Chronicles by Stephen Fry: https://amzn.to/2KAlLVR
SENS Research Foundation: https://www.sens.org/
Support SENS: https://www.sens.org/get-involved/
Podcast episode of Terminal Reading with KrioRus co-founder, part 1: https://tlg.name/mustreads/1981; part 2: https://tlg.name/mustreads/1989
Website of KrioRus: http://kriorus.ru/

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https://www.youtube.com/watch?v=WxIEMJR4X9Q&t=1s

Dr. Michael West, CEO of AgeX Therapeutics and Founder of Geron Corporation, discusses breakthroughs in the understanding of biological regeneration and in induced tissue regeneration, through his talk “Hayflick Rewound: Somatic Restriction, Epigenetics, and the Reversibility of Human Aging”. This talk was given at the Ending Age-Related Diseases conference in NYC. Join us at http://lifespan.io/hero

►Conference Page: https://www.leafscience.org/ending-age-related-diseases-advances-in-aging-research-and-investment-prospects/
►Subscribe for more: http://www.youtube.com/user/LifespanIO?sub_confirmation=1
►This video is presented by LEAF. Please support our work by becoming a “Lifespan Hero”: http://lifespan.io/hero

► #LifeExtension #MichaelWest #AgeX

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New research, published today in Nature, reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem cells to a younger, healthier state.

The results have far reaching implications for how we understand the ageing process, and how we might develop much-needed treatments for age-related diseases.

As our bodies age, muscles and joints can become stiff, making everyday movements more difficult. This study shows the same is true in our brains, and that age-related brain stiffening has a significant impact on the function of brain stem cells.

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Today, we’re releasing another keynote from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology.

In his talk, Estimating the True Complexity of Comprehensive Rejuvenation, the famous Aubrey de Grey of SENS Research Foundation discussed the intricacies of creating a complete rejuvenation biotechnology framework, including the differing rates of age-related damage and the ramifications of the extensive crosstalk between different types of this damage.

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A flamingo lives 40 years and a human being lives 90 years; a mouse lives two years and an elephant lives 60. Why? What determines the lifespan of a species? After analyzing nine species of mammals and birds, researchers at the Spanish National Cancer Research Center (CNIO) found a very clear relationship between the lifespan of these species and the shortening rate of their telomeres, the structures that protect the chromosomes and the genes they contain. The relationship is expressed as a mathematical equation, a formula that can accurately predict the longevity of the species. The study was done in collaboration with the Madrid Zoo Aquarium and the University of Barcelona.

“The telomere shortening rate is a powerful predictor of ,” the authors write in the prestigious journal Proceedings of the National Academy of Sciences (PNAS).

The study compares the telomeres of mice, goats, dolphins, gulls, reindeer, vultures, flamingos, elephants and humans, and reveals that species whose telomeres shorten faster have shorter lives.

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