Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

Haven’t heard from Fossel in awhile. This is long but well indexed in the notes.

My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself.

This video me, Brent Nally, interviewing Dr. Michael Fossel about Telocyte and telomerase gene therapy on November 16, 2019.

- Please consider a donation to me: My PayPal https://paypal.me/BrentNally or my Bitcoin Cash (BCH) address: qr9gcfv92pzwfwa5hj9sqk3ptcnr5jss2g78n7w6f2

SHOW NOTES:

0:20 Dr. Michael Fossel intro — Follow Michael on LinkedIn: https://www.linkedin.com/in/michael-fossel-4196255/ ; http://www.michaelfossel.com/
2:00 Planned January 2020 interview with Michael.
2:25 Buy Michael’s 3 books: 1) Reversing Human Aging 2) Cells Aging & Human Disease 3) The Telomerase Revolution.
4:15 https://telocyte.com/
5:07 Aging complexities
8:20 Small molecules won’t reverse human aging.
9:01 People are fixed in their incorrect beliefs about aging.
12:50 Sometimes we have to first go backwards to move forwards. My March 26, 2019 interview with Dr. Ed Park at Recharge Biomedical: https://youtube.com/watch?v=xHgfYKsH0uw&list=UUCwpkla04tVxHJUds2J2aqA&index=6
15:55 Economics of radically increasing the human healthspan.
19:01 Leonard Hayflick
21:05 The rate of telomere loss is linked to many organism’s lifespan.
22:30 Lengthening human telomeres in aging cells “resets” the cells to make them biologically younger.
24:10 Cells, Aging, and Human Disease preface.
28:20 human population if we radically increase human healthspan/lifespan.
31:20 biological vs chronological aging
32:25 telomerase activation is the best point of clinical and financial intervention to cure and prevent age related diseases.
37:30 Data generally doesn’t support the idea that making telomerase more active in humans can cause cancer. Michael beliefs this idea has been propagated by misinterpreting data.
45:02 Causation & Pathology in Alzheimer’s Disease.
46:30 standard cell aging process
49:53 What can you do to help cure human aging? understand the concepts, share this info & invest.
53:40 the FDA is excited about Telocyte’s model.
55:30 Phase 1 human FDA trial costs about $10 million but costs should drop after that.
57:50 It costs Telocyte about $4 million to initially produce the telomerase gene therapy they need to treat their first 12 patients.
58:55 Lets “elephant hunt” to find billionaire investors for Telocyte.
1:01:18 Michael discusses BioViva/Integrated Health Systems & Liz Parrish. My July 10, 2019 interview with BioViva CEO Liz Parrish: https://youtube.com/watch?v=oBFTwGPaPr4
1:02:10 My May 30, 2019 interview with Sierra Sciences CEO Dr. Bill Andrews: https://youtube.com/watch?v=Tx9yG6iTROQ
1:09:45 ethics and risks of telomerase gene therapy.
1:11:15 Unnatural selection on Netflix
1:14:30 Is reality a simulation?
1:18:10 The mind is like a parachute. It only works if it’s open. Data trumps everything always.
1:19:50 telomerase activator pills
1:24:30 Dr. Greg Fahy
1:28:40 https://lifelength.com/ & https://teloyears.com/home/
1:32:40 My July 17, 2019 interview with Dr. Aubrey de Grey https://www.youtube.com/watch?v=TquJyz7tGfk
1:38:34 Dr. Michael West
1:41:10 Inject snake venom for anti-aging? https://www.youtube.com/watch?v=8q_m-rDUNw0
1:45:15 Bill Haast https://en.wikipedia.org/wiki/Bill_Haast
1:45:50 My October 6, 2019 interview of Dr. Duncan Ross about Kimera exosomes: https://www.youtube.com/watch?v=X8eIxo3eqvQ&t=3s
1:46:15 Brent’s stem cell’s treatment and recovery playlist https://www.youtube.com/playlist?list=PLGjySL94COVQzsAauqp6lZHHzmzBQSmhH
1:51:52 Dr. Maria Blasco
1:52:45 Michael almost got $1 billion for a non-profit translational research for telomerase gene therapy from a wealthy couple in California in 1999.
1:55:45 Dr. Elizabeth Blackburn
1:57:57 Dr. Elissa Epel
2:00:09 Dr. Calvin Harley
2:02:20 Radical honesty and compassion
2:06:25 I recommend the book: Sapiens by Dr. Yuval Noah Harari
2:11:15 Michael’s fascinating experiences.
2:26:30 telomerase gene therapy economies of scale.
2:35:10 Dr. Peter Attia
2:36:50 Peter Rayson, CEO Telocyte. Curing human aging is a systems approach.
2:39:43 Forever Labs 1 year free cryogenic storage discount code ($250 value): BN801 https://foreverlabs.com
2:42:10 Dave Asprey — lack of funding for Telocyte is holding back the potential cure for Alzheimer’s.
2:44:30 Chan Zuckerberg Initiative
2:49:08 health advice
2:56:38 Viome for microbiome
3:01:04 the best current way to measure someone’s age is guessing based off how they look and behave.
3:04:51 transhumanism and ignosticism
3:08:23 Stay curious to continue learning.
3:16:28 “What important truth do very few people agree with you on?”
3:23:30 be considerate

- Intro music by: SoundSage
- Instagram: https://instagram.com/brent.nally/ & @cryptotravelcouple @Mrs_Nally_
- Facebook: https://facebook.com/brent.nally
- LinkedIn: https://linkedin.com/in/brentnally
- Twitter: https://twitter.com/BrentNally
- Patreon: https://patreon.com/user?u=9451534

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Chronic sleep loss could be linked to one sign of premature aging in the body, according to a new study published in Communications Biology. Using fitness tracker data, researchers showed that consumer sleep trackers can shine a light on the high costs of not getting enough sleep.

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Support the Channel by making a Donation ► https://goo.gl/ciSpg1
William H. Andrews ► https://goo.gl/vsNcbh

William Henry “Bill” Andrews, Ph.D. is an American molecular biologist and gerontologist whose career has centered on searching for a cure for human aging. Andrews is the founder and president of the biotechnology company Sierra Sciences. In 1997, he led the team at Geron Corporation that was the first to successfully identify human telomerase.

Dr. Bill Andrews is the creator of TAM-818, the world’s most powerful anti-aging active ingredient. TAM-818 is only found in One Truth 818 serum. For more information or to purchase visit http://www.tam818.com/

*Learn more about Dr. Bill Andrews and Sierra Sciences: http://www.sierrasci.com/

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Facebook: https://www.facebook.com/agingreversed
Twitter: https://twitter.com/Aging_Reversed
Support the Channel: https://goo.gl/ciSpg1
Channel t-shirt: https://teespring.com/aging-reversed

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On November 2, 12 bottles of Bordeaux wine were launched to the International Space Station (ISS). These bottles are not intended for holiday celebrations by the crew, however (consumption of alcohol is officially prohibited in space.) Instead. the bottles are part of an experiment conducted by the University of Bordeaux’s Institute of Vine and Wine Science (ISVV) and a company called Space Cargo Unlimited to investigate if the aging process of wine is affected by microgravity conditions.

As novel as this experiment sounds, the Bordeaux team is not the first group to examine how alcoholic beverages age in space. That distinction is held by two whisky producers, one in Scotland, the other in Japan. In 2011, Scotch whisky producer Ardbeg partnered with Nanoracks to launch the first whisky aging experiment in orbit. When the samples were returned to Earth in 2014, a clear difference was readily apparent from the control samples that remained on Earth—and not for the better. According to an Ardbeg white paper, the aftertaste was “pungent, intense and long, with hints of wood, antiseptic lozenges and rubbery smoke.” However, Ardbeg was not certain if this was a result of the aging process or other extreme factors that the samples encountered.

In 2015, Japanese whisky producer Suntory also launched whisky samples to be aged on the ISS. One batch of these samples returned to Earth for analysis after a year in orbit, but another batch still remains on the station. Thus far, Suntory has not released any data from these experiments.

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“Demonstrate That Top Financial and Tech Corporations Are Committed to Longevity”

This week two Landmark International Longevity Summits in London attracted the attention of scientists, government officials, major financial corporations, insurance companies, investment banks, and technology companies from around the world. The Landmark AI for Longevity Summit and the First International Longevity Policy and Governance Summit at King’s College London are expected to become the world-leading forums for the Longevity Industry.

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Some important news out today, and we hope to have an official announcement in the next 24 hours or so as my team makes final preparations. Thank you for your support!

Zoltan Istvan, a leader of the transhumanist movement to merge humans with technology, is challenging Trump with a plan for America that’s beyond radical.

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A new study is suggesting a metabolite produced by gut microbes could increase neuron production in the brain, improve intestinal function, and ultimately slow the aging process. Across several compelling mouse experiments the research found the negative effects of aging could be counteracted by enhanced microbial production of a molecule called butyrate.

Investigating the effect of the gut microbiome on aging, the new research first performed gut microbiome transplants between old and young mice. Using fecal transplants, young germ-free mice were colonized with the gut microbiota of older mice. The results were somewhat unexpected as the younger mice colonized with the older microbiomes displayed increased neurogenesis, a process whereby new neurons are produced in the brain.

“We’ve found that microbes collected from an old mouse have the capacity to support neural growth in a younger mouse,” explains Sven Pettersson, lead on the research team from Nanyang Technological University in Singapore. “This is a surprising and very interesting observation…”

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Award Program Honors the Achievement.

MOUNTAIN VIEW November 11, 2019 — Sens Research Foundation has been selected for the 2019 Best of Mountain View Award in the Medical Laboratory category by the Mountain View Award Program.

Each year, the Mountain View Award Program identifies companies that we believe have achieved exceptional marketing success in their local community and business category. These are local companies that enhance the positive image of small business through service to their customers and our community. These exceptional companies help make the Mountain View area a great place to live, work and play.

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The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with ‘Western’ diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched ‘Western’ diets can reprogram maternal bodily metabolism with maternal nutrient supply precipitating the body-wide imprinting of molecular and cellular adaptations at the level of long-range intercellular signaling networks in the unborn fetus. Even though unfavorable neurological outcomes are amongst the most common complications of intrauterine ω-6 PUFA excess, cellular underpinnings of life-long modifications to brain architecture remain unknown. Here, we show that nutritional ω-6 PUFA-derived endocannabinoids desensitize CB1 cannabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory networks controlling neuronal differentiation. We found that cortical neurons lose their positional identity and axonal selectivity when mouse fetuses are exposed to excess ω-6 PUFAs in utero. Conversion of ω-6 PUFAs into endocannabinoids disrupted the temporal precision of signaling at neuronal CB1 cannabinoid receptors, chiefly deregulating Stat3-dependent transcriptional cascades otherwise required to execute neuronal differentiation programs. Global proteomics identified the immunoglobulin family of cell adhesion molecules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramming at 1400 sites in neurons after prolonged cannabinoid exposure. We found anxiety and depression-like behavioral traits to manifest in adult offspring, which is consistent with genetic models of reduced IgCAM expression, to suggest causality for cortical wiring defects. Overall, our data uncover a regulatory mechanism whose disruption by maternal food choices could limit an offspring’s brain function for life.

  • Immediate Communication
  • Published: 18 November 2019
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