The novel coronavirus outbreak began in late December 2019 and rapidly spread worldwide, critically impacting public health systems. A number of already approved and marketed drugs are being tested for repurposing, including Favipiravir. We aim to investigate the efficacy and safety of Favipiravir in treatment of COVID-19 patients through a systematic review and meta-analysis. This systematic review and meta-analysis were reported in accordance with the PRISMA statement. We registered the protocol in the PROSPERO (CRD42020180032). All clinical trials which addressed the safety and efficacy of Favipiravir in comparison to other control groups for treatment of patients with confirmed infection with SARS-CoV2 were included. We searched electronic databases including LitCovid/PubMed, Scopus, Web of Sciences, Cochrane, and Scientific Information Database up to 31 December 2020.
3D printing, also called additive manufacturing, has become widespread in recent years. By building successive layers of raw material such as metals, plastics, and ceramics, it has the key advantage of being able to produce very complex shapes or geometries that would be nearly impossible to construct through more traditional methods such as carving, grinding, or molding.
The technology offers huge potential in the health care sector. For example, doctors can use it to make products to match a patient’s anatomy: a radiologist could create an exact replica of a patient’s spine to help plan surgery; a dentist could scan a patient’s broken tooth to make a perfectly fitting crown reproduction. But what if we took a step further and apply 3D printing techniques to neuroscience?
Stems cells are essentially the body’s raw materials; they are pluripotent elements from which all other cells with specialized functions are generated. The development of methods to isolate and generate human stem cells, has excited many with the promise of improved human cell function understanding, ultimately utilizing them for regeneration in disease and trauma. However, the traditional two-dimensional growth of derived neurones–using flat petri dishes–presents itself as a major confounding factor as it does not adequately mimic in vivo three-dimensional interactions, nor the myriad developmental cues present in real living organisms.
To address this limitation in current neuronal culturing approaches, the FET funded MESO-BRAIN project, led by Aston University, proposed a highly ambitious interdisciplinary enterprise to construct truly 3D networks that not only displayed in vivo activity patterns of neural cultures but also allowed for precise interaction with these cultures. This allows the activity of individual elements to be readily monitored and controlled through electrical stimulation.
The ability to develop human-induced pluripotent stem cell derived neural networks upon a defined and reproducible 3D scaffold that can emulate brain activity, allows for a comprehensive and detailed investigation of neural network development.
The MESO-BRAIN project facilitates a better understanding of human disease progression, neuronal growth and enables the development of large-scale human cell-based assays to test the modulatory effects of pharmacological and toxicological compounds on neural network activity. This can ultimately help to better understand and treat neurological conditions such as Parkinson’s disease, dementia, and trauma. In addition, the use of more physiologically relevant human models will increase drug screening efficiency and reduce the need for animal testing.
While the world was distracted with the rampant spread of a novel coronavirus, 2020 also witnessed an explosion in another deadly pathogen that could pose a threat to global public health.
H5N8, a subtype of highly pathogenic avian influenza virus (HPAIV), was identified decades ago, but during 2020 a series of emerging and ongoing H5N8 outbreaks in avian populations across dozens of countries have led to the death or slaughter of millions of birds worldwide.
“The affected geographic regions have been expanding continuously, and at least 46 countries have reported highly pathogenic H5N8 AIV outbreaks,” virus researchers Weifeng Shi and George F. Gao write in a new perspective article in Science, warning of the dangers of H5N8 if we don’t closely monitor and contain this worrisome trend.
Artificial intelligence tool can be used for long-term tracking and management of chronic gastrointestinal ailments.
An artificial intelligence tool under development at Duke University can be added to the standard toilet to help analyze patients’ stool and give gastroenterologists the information they need to provide appropriate treatment, according to research that was selected for presentation at Digestive Disease Week® (DDW) 2021. The new technology could assist in managing chronic gastrointestinal issues such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).
“Typically, gastroenterologists have to rely on patient self-reported information about their stool to help determine the cause of their gastrointestinal health issues, which can be very unreliable,” said Deborah Fisher, MD, one of the lead authors on the study and associate professor of medicine at Duke University Durham, North Carolina. “Patients often can’t remember what their stool looks like or how often they have a bowel movement, which is part of the standard monitoring process. The Smart Toilet technology will allow us to gather the long-term information needed to make a more accurate and timely diagnosis of chronic gastrointestinal problems.”
The continuing miniaturization of electronics is opening up some exciting possibilities when it comes to what we might place in our bodies to monitor and improve our health. Engineers at Columbia University have demonstrated an extreme version of this technology, developing the smallest single-chip system ever created, which could be implanted with a hypodermic needle to measure temperature inside the body, and possibly much more.
From ladybug-sized implants that track oxygen levels in deep body tissues to tiny “neural dust” sensors that monitor nerve signals in real time, scientists are making big steps when it comes to the functionality of tiny electronic devices. The implant developed by the Columbia Engineers breaks new ground as the world’s smallest single-chip system, which is a completely functional electronic circuit with a total volume of less than 0.1 mm3.
That makes it as small as a dust mite, and only visible under a microscope. The tiny chip required some outside-the-box thinking to make, particularly when it comes to the way it communicates and is powered.
If you’ve been to your local beach, you may have noticed the wind tossing around litter such as an empty potato chip bag or a plastic straw. These plastics often make their way into the ocean, affecting not only marine life and the environment but also threatening food safety and human health.
Eventually, many of these plastics break down into microscopic sizes, making it hard for scientists to quantify and measure them. Researchers call these incredibly small fragments nanoplastics and microplastics because they are not visible to the naked eye. Now, in a multiorganizational effort led by the National Institute of Standards and Technology (NIST) and the European Commission’s Joint Research Centre (JRC), researchers are turning to a lower part of the food chain to solve this problem.
The researchers have developed a novel method that uses a filter-feeding marine species to collect these tiny plastics from ocean water. The team published its findings as a proof-of-principle study in the scientific journal Microplastics and Nanoplastics.
The U.S. Army teased footage of its new night-vision goggles — and it’s straight out of an RPG video game. This is the first-person POV of a soldier participating in a live training exercise.
Scientists said the findings indicated that the virus likely recently jumped from animals to humans, but stressed that additional studies are necessary.
Scientists have reportedly discovered a new kind of coronavirus that is believed to have originated in dogs – in what may be the eighth unique form of the bug known to cause disease in humans.
Researchers in a study published in the Clinical Infectious Diseases journal said their findings from patients hospitalized with pneumonia in 2017–2018 underscored the public health threat of animal coronaviruses, Reuters reported.
They said they had tested nasal swab samples taken from 301 pneumonia patients at a hospital in the east Malaysian state of Sarawak.
Pediatrician, Medical Innovator, Educator — Dr. Jamie Wells, MD, FAAP — Director, Research Science Institute (RSI), Center for Excellence in Education, Massachusetts Institute of Technology (MIT) — Professor, Drexel University School of Biomedical Engineering, Science and Health Systems.
Dr. Jamie L. Wells, MD, FAAP, is an Adjunct Professor at Drexel University’s School of Biomedical Engineering, Science and Health Systems, where she has been involved in helping to spearhead the nation’s first-degree program focused on pediatric engineering, innovation, and medical advancement.
Dr. Wells is an award-winning Board-certified pediatrician with many years of experience caring for patients. With her BA with Honors from Yale, and her MD from Jefferson Medical College, Philadelphia, PA, she has served as a Clinical Instructor/Attending at NYU Langone, Mt. Sinai-Beth Israel and St. Vincent’s Medical Centers in Manhattan.
Dr. Wells is on the leadership council of the Wistar Institute (the USA’s first independent biomedical research facility and certified cancer center), Ambassador of the Healthcare Global Blockchain Business Council, was a grant reviewer for the Susan G. Komen Community Grants Program, judged both the local, district and world robotics championships for Dean Kamen’s F.I.R.S.T. (For Inspiration & Recognition of Science & Technology) nonprofit, as well as the Miss America’s Outstanding Teen scholarship competition (for which she is now a member of its Board of Directors), and is the Chair of the Yale Alumni Health Network (YAHN).
Dr. Wells has a proven track record of success in communications on various platforms (e.g. BBC, Reuters TV, Fox News Channel, Discovery Health), routinely appearing as a medical expert and has published over 400 articles as director of medicine for an educational advocacy nonprofit.
Dr. Wells has broad ranging interests in patient safety and optimizing care delivery, bioethics, public health and policy, science communications, med-tech innovation, diagnosis and management of disease, identifying healthcare trends, bridging interdisciplinary knowledge gaps to prevent medical error and expedite discovery, thought integration of clinical practice and biomedical engineering approaches with an emphasis on patient-centered design, debunking medical myths and pediatrics.
To watch this keynote interpreted in American Sign Language (ASL), please click here:
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