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Thanks to Amazon’s success, CEO Jeff Bezos is the richest person in the world, worth $207 billion, according to the Bloomberg Billionaires Index.

But when he started Amazon as an online bookseller in 1994, Bezos thought it was likely that his business would fail.

“I thought there was a 30% chance that we might build a successful company,” Bezos told John Stofflet in an interview for KING-TVs “Evening Magazine” in 2000. “I never thought we’d build what Amazon has turned into, and I’m the most surprised on the planet.”

The masks could screen for the coronavirus at airports, hospitals, and offices. They could also double as a diagnostic test.


Sensors produce a fluorescent light when an infected person breathes, coughs, or sneezes into the mask.

BACKGROUND

A closed-loop system of insulin delivery (also called an artificial pancreas) may improve glycemic outcomes in children with type 1 diabetes.

METHODS

In a 16-week, multicenter, randomized, open-label, parallel-group trial, we assigned, in a 3:1 ratio, children 6 to 13 years of age who had type 1 diabetes to receive treatment with the use of either a closed-loop system of insulin delivery (closed-loop group) or a sensor-augmented insulin pump (control group). The primary outcome was the percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter, as measured by continuous glucose monitoring.

RESULTS

A total of 101 children underwent randomization (78 to the closed-loop group and 23 to the control group); the glycated hemoglobin levels at baseline ranged from 5.7 to 10.1%. The mean (±SD) percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter increased from 53±17% at baseline to 67±10% (the mean over 16 weeks of treatment) in the closed-loop group and from 51±16% to 55±13% in the control group (mean adjusted difference, 11 percentage points [equivalent to 2.6 hours per day]; 95% confidence interval, 7 to 14; P<0.001). In both groups, the median percentage of time that the glucose level was below 70 mg per deciliter was low (1.6% in the closed-loop group and 1.8% in the control group). In the closed-loop group, the median percentage of time that the system was in the closed-loop mode was 93% (interquartile range, 91 to 95). No episodes of diabetic ketoacidosis or severe hypoglycemia occurred in either group.


Address reprint requests to Dr. Wadwa at the Barbara Davis Center for Diabetes, 1775 Aurora Ct., Aurora, CO 80045, or at [email protected].

A complete list of the members of the International Diabetes Closed Loop (iDCL) Trial Research Group is provided in the Supplementary Appendix, available at NEJM.org.

China’s Xiaomi has launched a new TV as part of the 10th anniversary celebration that also saw the announcement of the Mi 10 Ultra smartphone. The Mi TV Lux Transparent Edition brings sci-fi into the living room with an edge-to-edge self-luminous television that you can see through.

We’ve seen a few transparent televisions and screens from industry big hitters like Samsung, LG and Panasonic over the years, but Xiaomi says its Mi TV Lux Transparent Edition is the first to go into mass production.

The 55-inch OLED panel is just 5.7-mm thin and sits on a rounded base and, when the TV isn’t powered on, the display looks like a window between you and whatever is behind it – though it can be set to show arty display images if desired. But Xiaomi is promising an “unprecedented visual experience” when it’s switched on, with “extra rich blacks and unmatched brightness.”