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Category: bioengineering

Check out the science of biohacking, where biologists go into a patient’s genetic code and reprogram their immune system to recognize and fight cancer cells.

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The human body is made up of about 30 trillion cells that carry a code which has been duplicated over and over for billions of years — with varying degrees of accuracy. So what happens when the system breaks down and the machinery turns on itself, leading to cancer? Greg Foot dives into the science of how biologists are biohacking the human body to try to fix the seemingly unfixable.

Lesson by Greg Foot, directed by Pierangelo Pirak.

Produced for ted-ed by NIHR university college london hospitals biomedical research centre.

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View full lesson: https://ed.ted.com/lessons/how-to-biohack-your-cells-to-fight-cancer-greg-foot

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In a paper to be published in the forthcoming issue in NANO, a team of researchers from the School of Chemistry and Chemical Engineering at Hunan University of Science and Technology have proposed a novel strategy for the synthesis of non-precious metal catalysts in zinc-air batteries that do not compromise its electroactivity, affordability and stability.

As a green and sustainable energy generator, zinc-air battery has attracted great attention from researchers due to its high specific energy, high current density, low cost, and environmental friendliness. Yet it is not without its drawbacks. The slow oxygen reduction reaction (ORR) of its cathode has become an obstacle to its commercial application. One possible solution is to use platinum (Pt) and Pt-based catalysts, but its high cost and scarce availability make it less ideal. In addition, alkaline KOH (or NaOH) is generally used as the electrolyte, but it leads to the generation of carbonates (CO32-) due to the dissolution of CO2 in the electrolyte as well as the spontaneous corrosion of the anodic zinc in strong alkaline media. This has the effect of slowing down the ionic conductivity of the electrolyte and battery life. Therefore, a neutral electrolyte should be used instead.

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Following recent trends in state-of-the-art developments, from cryptocurrencies and universal basic income to biohacking and the surveillance state, transhumanism has been moved into the limelight of political discourse to reshape humanity’s future.

Andrew Vladimirov, Information security specialist, biohacker and one of the original members of the Transhumanist Party UK, spoke in-depth with Sputnik about the rise of transhumanism and its implications.

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Researchers at the Auckland Bioengineering Institute and Technische Universit\xE4t Dresden have recently designed a new type of inflatable robot for space navigation. These robots, presented in a paper published in SPIE Digital Library, were created using dielectric elastomer transducers (DETs), which are essentially electrical capacitors made from soft rubbery materials.

“Current technology is limited by its mass and volume. It takes thousands of dollars to launch even a single kilogram into orbit,” Joseph Ashby, one of the researchers who carried out the study, told TechXplore. “Our research aims to replace or augment current technology with lighter smart-material replacements combined with inflatable structures.”

If they are integrated with inflatable structures, DETs could aid the development of soft and low-mass robots, which have high packaging efficiency and are easy to deploy. In fact, DETs deform when a voltage is applied to them, due to the Maxwell stress generated by the electric field.

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“Ruby, along with her company Applied Stem Cell, is one of the world’s most respected experts in gene editing. We are delighted to be working with her on our ambitious project to transform the potential of somatic gene therapy, in terms of both its safety from creating unwanted mutations and its efficacy in delivering large amounts of DNA, which is founded on some pioneering work at Stanford in which she was also heavily involved.” says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-ruby-yanru-chen-tsai-to-speak-at-undoing-aging-2019?fbclid=IwAR0r-zVDdTyASv0QqodVykIvOkf7XR5oBIDN45KzRjBfV1ysJb5IQ0dQ64s

#undoingaging #sens #foreverhealthy

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A fringe group of scientists and tech moguls think they’re closing in on the fountain of youth. Here’s everything you need to know:

What is biohacking? Silicon Valley is built on the idea that technology can optimize, or “hack,” any aspect of our lives — so why not the human life span? Until recently, anyone hawking pills or treatments that promised to restore youthfulness was considered a quack, yet a growing number of “transhumanists” are convinced that, in time, human beings can be transformed through bioengineering, and that aging will be curable just like any other malady.

In light of rapid gains in gene editing, nanotechnology, and robotics, some futurists expect this generation’s biohackers to double their life spans. Aubrey de Grey, a regenerative medicine researcher backed by tech mogul Peter Thiel, insists that someone alive today will live to be 1,000. “It’s extraordinary to me that it’s such an incendiary claim,” de Grey says. Korean physician and financier Joon Yun has offered two $500,000 prizes to anyone who can restore a test animal’s youthful heart rate and extend its lifespan by 50 percent. For humans, the mortality rate at age 20 is 0.001 percent, Yun figures, “so if you could maintain the homeostatic capacity of that age throughout your life, your average life span would be 1,000.”

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A team of researchers from Nanjing and Xiamen Universities in China has developed an alternative to using viruses to transport CRISPR-Cas9 gene editing tools into a desired cell—and it involves two types of light. In their paper published in the journal Science Advances, the group describes their new type of carrier and how well it worked with test mice.

CRISPR-Cas9 gene editing tools are a coming revolution in treating genetic conditions, and scientists continue to test their abilities in a variety of applications. One area of study has involved looking for a replacement carrier system—the current approach uses a virus to carry the gene editing tool into a particular cell. Early on, researchers knew that the virus approach was not viable because of possible responses from the , or worse, the threat of initiating tumors. In this new effort, the team in China has come up with an entirely new way to deliver the gene editing tool using two kinds of light.

Their carrier system consists of nanoparticles that are sensitive to low-energy near– (NIR) and that emit UV light. When NIR is shone on the nanoparticles, the light is absorbed and converted to UV light, which is emitted. Inside of a cell, the package is activated by shining NIR onto the skin, where it penetrates into the body and makes its way to the gene editing tool. When the NIR is converted to UV light, it cuts molecules in the carrier package, releasing the gene editing tool to do its work.

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Artificial cells created inside the lab have taken another major step forward, with scientists developing cells that are able to produce their own chemical energy and synthesise parts of their own construction.

That makes these artificial cells a lot more like real, biological cells – cells that can construct and organise their own building blocks naturally.

Not only could this help us understand how real cells work and come into being in the first place, it could also be vital for a host of other areas of research – such as ongoing efforts to produce artificial organs and other body tissue to fight back against disease.

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