On Tuesday, the two feuding parties of the CRISPR gene editing patent fight entered the boxing ring: attorneys for each side made oral arguments before three-judge panel, in a case that not only puts billions of potential dollars at stake, but could define the future of genetic engineering.
The fourth Lifespan.io campaign and CellAge are using synthetic biology to create an accurate aging biomarker for senescent cells and a new therapy for precision targeting of those problem cells. Senescent cells are one of the processes of aging and this could change the way we age.
Lifespan.io is proud to present our fourth rejuvenation biotechnology project!
As we age our bodies accumulate damage in the form of dysfunctional cells that have entered a state called “senescence”, which secrete toxic signals that can lead to chronic inflammation, higher rates of cancer and additional aging-related conditions.
In order to address this CellAge, an Edinburgh based startup, has just launched a new Lifespan.io campaign to develop methods that will help researchers target, and eventually remove, these cells from the body and thereby assist in restoring it to youthful functionality.
Central to their project is the development of new synthetic DNA promoters which are specific to senescent cells, as promoters that are currently being used to track them, such as the p16 gene promoter, have various limitations. If successful, they will follow this up by validating gene therapies for senescent cell removal, initially for patients with progeroid syndromes, those who have undergone radiotherapy, and eventually those with age-related disease.
It is not often that a scientist walks the red carpet at a Silicon Valley party and has Morgan Freeman award them millions of dollars while Alicia Keys performs on stage and other A-listers rub shoulders with NASA astronauts.
But the guest list for the Breakthrough prize ceremony is intended to make it an occasion. At the fifth such event in California last night, a handful of the world’s top researchers left their labs behind for the limelight. Honoured for their work on black holes and string theory, DNA repair and rare diseases, and unfathomable modifications to Schrödinger’s equation, they went home to newly recharged bank accounts.
Founded by Yuri Milner, the billionaire tech investor, with Facebook’s Mark Zuckerberg and Google’s Sergey Brin, the Breakthrough prizes aim to right a perceived wrong: that scientists and engineers are not appreciated by society. With lucrative prizes and a lavish party dubbed “the Oscars of science”, Milner and his companions want to elevate scientists to rock star status.
The US Army Research Laboratory (ARL) are at an advanced stage of with their synthetic biology research. The work could see bacteria being used to send signals and sense in a way similar to computers, the advantage being that it could potentially provide a more intuitive sensory experience to a piece of tech, and bypass some of the pitfalls unique to electrical structures. The research also has application for new 3D printing materials.
In an epidsode of the dystopian near-future series, Black Mirror, a small, implantable device behind the ear grants the ability to remember, access, and replay every moment of your life in perfect detail, like a movie right before your eyes.
Theodore Berger, a biomedical engineer at the University of Southern California, can’t promise that level of perfect recall—perhaps for the better—but he is working on a memory prosthesis. The device, surgically implanted directly into the brain, mimics the function of a structure called the hippocampus by electrically stimulating the brain in a particular way to form memories—at least in rats and monkeys. And now, he’s testing one that could work in humans.
Berger’s device hinges on a theory about how the hippocampus transforms short-term memories, like where you deposited your keys, into long-term memories—so you can find them later. In his early experiments, he played a tone and then puffed air in a rabbit’s face, causing it to blink. Eventually, just playing the tone would make the rabbit blink, just like Pavlov’s famous salivating dogs. Berger recorded the hippocampus’ activity with electrodes, and as the rabbits learned to associate the tone with the air puff, patterns in those signals changed in a predictable way.
More on the cell circuited technology that will deprive cancer cells of oxygen.
Imagine having cells in your body that can actively repel cancer in a way that makes it theoretically impossible for you to suffer from it.
Researchers at the U.K.’s University of Southampton…have engineered cells with a so-called “built-in genetic circuit” capable of producing a molecule for inhibiting the ability of tumors to grow and survive in the body.
“There are various defense mechanisms built into human cells, such as proteins that spot DNA damage, but there are also gaps in this defense system that are exploited by disease,” Professor Ali Tavassoli, one of the lead authors of the paper …“We were wondering if it is possible to equip human cells with the ability to sense and respond to a disease marker…”
https://youtube.com/watch?v=ySsv5-jSqss
BMI implant leveraging AI.
You probably clicked on this article because the idea of using brain implants to allow artificial intelligence (AI) to read your brain sounds futuristic and fascinating. It is fascinating, but it’s not as futuristic as you might think. Before we start talking about brain implants and how to augment the human brain using AI, we need to put some context around human intelligence and why we might want to tinker with it.
We floated the idea before that gene editing techniques could allow us to promote genetic intelligence by performing gene editing at the germline. That’s one approach. As controversial as it might be, some solid scientific research shows that genetics does play a role in intelligence. For those of us who are already alive and well, this sort of intelligence enhancement won’t work. This is where we might look towards augmented intelligence. This sort of augmentation of the brain will firstly be preventative in that it will look to assist those who have age associated brain disorders as an example. In order for augmented intelligence to be feasible though, we need a read/write interface to the human brain. One company called Kernel might be looking to address this with a technology that takes a page out of science fiction.
I have been evangelizing this for a while and glad to see others chiming in.
London, Nov 26 (IANS) Researchers have engineered cells with a “built-in genetic circuit” that produces a molecule that impairs the ability of cancer cells to survive and grow in their low oxygen environment.
The genetic circuit produces the machinery necessary for the production of a compound that inhibits a protein which has a significant and critical role in the growth and survival of tumours.
This results in the cancer cells being unable to survive in the low oxygen, low nutrient tumour micro-environment.
