That wisdom from Ecclesiastes is the theme of five new novels, which, if they did not give me a taste of immortality, at least made me feel like the week would never end. The coincidence of their arrival is a little creepy, but it suggests the growing relevance of this subject for a generation reviewing itineraries to the undiscovered country with deep ambivalence. In shades of comedy and tragedy, realism and fantasy, these contemporary authors dig up a lot of old conceits and, like Dr. Frankenstein, zap them to life with mixed results.

The dark side of immortality: “How to Stop Time,” “Eternal,” “The Immortalists,” “Immortal Life” and “The Afterlives.”

As part of our ongoing series covering the hallmarks of aging, we are taking a look at deregulated nutrient sensing today and how these four pathways regulate metabolism and influence aging.

To understand studies on nutrient sensing in the context of aging, let’s introduce four key protein groups. In this post, we’ll explore the pathways they help control and how they affect aging. These key proteins are IGF-1, mTOR, sirtuins, and AMPK[2]. We call these proteins “nutrient sensing” because nutrient levels influence their activity[2].