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Today we have the transcript of “Pursuing Outreach Opportunities: Lifespan.io’s Experiences in Promoting Healthy Life Extension”, a talk that LEAF Outreach Director Elena Milova gave at TransVision 2018, a transhumanist conference in Madrid, Spain recently.


This is the transcript of “Pursuing Outreach Opportunities: Lifespan.io’s Experiences in Promoting Healthy Life Extension”, a talk that LEAF Outreach Director Elena Milova gave at TransVision 2018, a transhumanist conference in Madrid, Spain.

My name is Elena Milova, and I work with the Life Extension Advocacy Foundation, a non-profit organization headquartered in New York City. Our main activity is to support research on regenerative therapies that can possibly make human life healthier and longer. To do that, we have developed the non-profit crowdfunding platform Lifespan.io, and, as of now, we have gathered more than 300 thousand dollars in support of 7 scientific projects. We are currently running a campaign to support David Sinclair’s NAD+ Mouse project, a study of NMN and its effect on healthy lifespan in mice.

Another direction of our activity is to educate the public about the potential of rejuvenation therapies.

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Protein RbAp48 works with osteocalcin to preserve memory in old age.


In a recent open-access study, scientists at Columbia University have demonstrated that a protein known as RbAp48 crucially interacts with osteocalcin to help preserve memory. The protein, which is present in mice as well as people, declines with age, contributing to age-related memory loss [1].

Abstract

Precisely deciphering the molecular mechanisms of age-related memory loss is crucial to create appropriate therapeutic interventions. We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss. By exploring how this protein regulates the genomic landscape of the hippocampal circuit, we find that RbAp48 controls the expression of BDNF and GPR158 proteins, both critical components of osteocalcin (OCN) signaling in the mouse hippocampus. We show that inhibition of RbAp48 in the hippocampal formation inhibits OCN’s beneficial functions in cognition and causes deficits in discrimination memory. In turn, disruption of OCN/GPR158 signaling leads to the downregulation of RbAp48 protein, mimicking the discrimination memory deficits observed in the aged hippocampus. We also show that activation of the OCN/GPR158 pathway increases the expression of RbAp48 in the aged dentate gyrus and rescues age-related memory loss.

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We’re on the cusp of the #Apollo50 anniversary of America’s great achievement that landed a dozen astronauts on the Moon between July 1969 and December 1972 and our first crewed mission – Apollo 8 – that circumnavigated the Moon in December 1968. Take a look: https://go.nasa.gov/2CN3KQH

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SpaceX has confirmed that the two large propellant tanks now present at its Boca Chica, Texas facilities will likely to be the last major ground tanks needed to enable the first test flights of the upper stage of its next-gen BFR rocket, known as the Big Falcon Spaceship (BFS).

Expected to begin as soon as late 2019, SpaceX executives have recently reiterated plans for a campaign of hop tests for the first full-scale spaceship prototype, in which the ship will follow in the footsteps of its Falcon 9-based Grasshopper and F9R predecessors.

SpaceX Project Making Progress at Boca Chica Beach Site http://www.krgv.com/story/39360667/spacex-project-making-progress-at-boca-chica-beach-site#.W9LadRUa4sw.twitter

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https://www.youtube.com/watch?v=dgn7mZODnag

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In the last video in this series we discussed the ancient origins of artificial intelligence progressing forward to the beginnings of the development of modern computing based artificial intelligence, encompassing the philosophies, theories and inventions of many talented individuals and groups.

The focus of this video will continue right were the last one left off, so sit back, relax and join me on an exploration on the official birth of modern artificial intelligence leading to present day!

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Memes are not just learned, they run deeper than that, they are part of our shared experience as human beings. This is how we communicate to each other through spoken, written, and body language; this is how we participate in customs, rituals and cultural traditions. Indeed, human civilization has always been a “cultured” virtual reality. We don’t often think of cultures as virtual realities, but there is no more apt descriptor for our widely diverse sociology and interpretations than the metaphor of the “virtual reality.” In truth, the virtual reality metaphor encompasses the entire human enterprise. We should realize that all our ideologies and religions, our belief systems and models of reality are our own personal operating systems — real to us but wry to someone else — each of us lives in a seemingly shared but simultaneously private virtual world.


By Alex Vikoulov.

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“We live in succession, in division, in parts, in particles. Meantime within man is the soul of the whole; the wise silence; the universal beauty, to which every part and particle is equally related; the eternal One. And this deep power in which we exist, and whose beatitude is all accessible to us, is not only self-sufficing and perfect in every hour, but the act of seeing and the thing seen, the seer and the spectacle, the subject and the object, are one. We see the world piece by piece, as the sun, the moon, the animal, the tree; but the whole, of which these are the shining parts, is the soul.” — Ralph Waldo Emerson, “The Over-Soul” (1841)

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Exposure to toxic air both indoors and out kills some 600,000 children under the age of 15 each year, the World Health Organization warned Monday.

Data from the UN health body shows that every day, 93 percent of children under the age of 15—a full 1.8 billion youngsters, including 630 million under the age of five—breath dangerously polluted air.

This has tragic consequences: In 2016 alone, some 600,000 children died from acute caused by polluted air, the WHO report found.

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Nuclear engine (aka YaEDU):


A key component of Russia’s future nuclear space propulsion system, which may revolutionize long-range exploration of the solar system, has been successfully tested, RIA Novosti reported.

Since at least 2009, Russian space and atomic engineers have been developing a special space propulsion system, which uses a 1 megawatt nuclear fusion reactor as source of energy. According to a work competition report, published on a website tracing public spending in Russia and reviewed by the news agency, one of the crucial elements of the system, which is responsible for cooling down the reactor, has been successfully tested.

The nuclear engine, which is known by its abbreviation YaEDU (Nuclear Propulsion and Power Engine System) consists of a small fast-neutron nuclear reactor, an electricity generator fed by the reactor’s heat and space thrusters powered by the generator.

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China’s aerospace industry has traditionally been the domain of state-owned institutes and enterprises, but a huge amount of investment has poured into the private sector since 2015 when Beijing announced a national strategy to integrate military and civilian businesses.


Landspace Tech’s ZQ-1 took off from Jiuquan Satellite Launch Centre at 4pm on Saturday carrying a small satellite for state broadcaster CCTVMission failed due to problem with rocket’s third stage, company says.

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