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Intervene Immune is a company focused on the age-related decline of the immune system, which is known as immunosenescence. Here, Bobby Brooke, CEO of Intervene Immune, discusses the clinical potential of regenerating the thymus as a means of reversing age-related immune system decline.


Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. This was a conference designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights.

As the human body ages, the thymus begins to shrink, and fewer numbers of T cells are created and trained to fight. The thymus tissue also turns to fat rather than healthy immune cell-producing thymic tissue. Eventually, the thymus wastes away, becoming a useless fatty organ that no longer produces immune cells.

This structural decay of the thymus and the failure of the immune system when we are old opens us up to multiple age-related diseases, particularly cancer, along with infectious diseases, such as pneumonia and flu.

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The particle physicists at the Niels Bohr Institute have obtained new results, working with the LHC, replacing the lead-ions, usually used for collisions, with Xenon-ions. Xenon is a “smaller” atom with fewer nucleons in its nucleus. When colliding ions, the scientists create a fireball that recreates the initial conditions of the universe at temperatures in excess of several thousand billion degrees. In contrast to the Universe, the lifetime of the droplets of QGP produced in the laboratory is ultra short, a fraction of a second (In technical terms, only about 10-22 seconds). Under these conditions the density of quarks and gluons is very large and a special state of matter is formed in which quarks and gluons are quasi-free (dubbed the strongly interacting QGP). The experiments reveal that the primordial matter, the instant before atoms formed, behaves like a liquid that can be described in terms of hydrodynamics.

How to approach “the moment of creation”

“One of the challenges we are facing is that, in heavy ion collisions, only the information of the final state of the many particles which are detected by the experiments are directly available – but we want to know what happened in the beginning of the collision and first few moments afterwards”, You Zhou, Postdoc in the research group Experimental Subatomic Physics at the Niels Bohr Institute, explains. “We have developed new and powerful tools to investigate the properties of the small droplet of QGP (early universe) that we create in the experiments”. They rely on studying the spatial distribution of the many thousands of particles that emerge from the collisions when the quarks and gluons have been trapped into the particles that the Universe consists of today. This reflects not only the initial geometry of the collision, but is sensitive to the properties of the QGP. It can be viewed as a hydrodynamical flow.

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To understand the mechanisms by which molecules act in cells, or the effects of drugs on them, it would be ideal to be able to track individual molecules, including where in the cell they are located and what modifications they undergo when conditions in the cell change. However, this has proven difficult with existing technologies, particularly given the amount of time required to perform such monitoring.

A research team centered at Osaka University, in collaboration with RIKEN, has developed a system that can overcome these difficulties by automatically searching for, focusing on, imaging, and tracking single within living . The team showed that this approach could analyze hundreds of thousands of single molecules in hundreds of cells in a short period, providing reliable data on the status and dynamics of molecules of interest.

For the development of this method, reported in the journal Nature Communications, the team used an -based system, involving the training of to learn to focus correctly on a sample and to automatically search for cells, followed by the tracking of single fluorescently labeled molecules with a total internal reflection fluorescence microscope.

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China’s first Mars simulation base opened to the press on Friday in Gansu Province in the northwest of the country, providing a glimpse of the project mainly intended to popularise space among youth.

The base is located in the Gobi Desert, 40 kilometres away from the downtown area of Jinchang, a city in Gansu. The natural features, landscape and climate are being described as resembling Martian conditions.

The newly-built base has an extravehicular site and nine modules, including an airlock module, a general control module and a bio-module.

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Crop Trust guards about one million varieties of seeds in a mountain in Svalbard, Norway. The doomsday vault is the back-up for 1,700 seed banks worldwide, in the event of some future apocalypse.


The term “conservation” may bring wildlife or land preservation to mind. But what about the food we eat?

According to Crop Trust, an international organization working to safeguard agriculture, we only use about 1 percent of available crops to fuel our diets. That could put the future of our food system at risk.

That’s why Erik Oberholtzer helped to gather leaders in the restaurant industry last week at Google’s New York City office in an effort to encourage a more diverse and delicious future. On the menu was Breadfruit Tikki, Teff Tacos and Fonio Salad.

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The tech world’s latest virtual assistant looks so realistic, you might mistake her for an actual human.

Apple has Siri, and Amazon has Alexa. But the lifelikeness of both are dwarfed by Mica: a prototype that Magic Leap, a highly regarded augmented-reality startup, unveiled at its conference Wednesday.

Mica isn’t just a voice assistant. She’s something you can actually see if you wear the company’s augmented-reality glasses, called Magic Leap One. Mica looks and acts like a human — she makes eye contact and offers a warm smile, along with other human-like expressions.

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Tesla is shaking up the automotive industry. But which of Tesla’s products and features are doing the disrupting, and who will be affected? A recent article by Benedict Evans delves into the details of this automotive disruption with comparisons to similar shake ups in the tech industry.

Evans uses the disruptive wave that Apple unleashed on Palm, Nokia, and other makers of previous-generation cell phones as an analogy. “When Nokia’s people looked at the first iPhone, they saw a not-great phone with some cool features that they were going to build too, being produced at a small fraction of the volumes they were selling,” he writes. “When many car company people look at a Tesla, they see a not-great car with some cool features that they’re going to build too, being produced at a small fraction of the volumes they’re selling.”

But can Tesla be considered the Apple of the auto industry, and if so, what would that mean? Disruption occurs when a new technology or concept changes the basis of competition in a field. However, not every new technology turns out to be disruptive. “Some things do not change the basis of competition enough, and for some things the incumbents are able to learn and absorb the new concept instead,” writes Evans, noting that business professor Clay Christensen calls this “sustaining innovation” as opposed to “disruptive innovation”.

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“Once such superhumans appear, there are going to be significant political problems with the unimproved humans, who won’t be able to compete,” suggests the late physicist and author Stephen Hawking in The Sunday Times. “Presumably, they will die out, or become unimportant. Instead, there will be a race of self-designing beings who are improving themselves at an ever-increasing rate. If the human race manages to redesign itself, it will probably spread out and colonize other planets and stars.”

Hawking has caused an uproar by suggesting a new race of superhumans could develop from wealthy people choosing to edit their DNA. “There is no time to wait for Darwinian evolution to make us more intelligent and better natured. But we are now entering a new phase of what might be called self-designed evolution, in which we will be able to change and improve our DNA. We have now mapped DNA, which means we have read “the book of life”, so we can start writing in corrections.”

Hawking, who died in March, presented the possibility that genetic engineering could create a new species of superhuman that could destroy the rest of humanity. The essays, published in the Sunday Times, were written in preparation for a book that will be published on Tuesday.

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